Abstract: Described herein is an antigen binding moiety comprising an anti-IL-4R moiety or an antigen binding portion thereof, an anti-TSLP moiety or an antigen binding portion thereof, and/or an anti-TSLPR moiety and methods of use. The antigen binding moiety described herein can block activity of IL4-IL-4R binding/interaction and/or TSLP-TSLPR/IL7R? binding/interaction. In some embodiments, the antigen binding moiety described herein can block activity of TSLP and/or IL4 induced or mediated signaling, that is comparable or higher than that of a monospecific anti-IL-4R or anti-TSLP antibodies (e.g., Dupilumab and Tezepelumab, respectively) or a combination treatment (e.g., sequential or co-administration) of the monospecific anti-IL-4R and anti TSLP antibodies.

Abstract: Disclosed herein is method of treating cancer comprising administration of memory NK cells and a monoclonal antibody comprising a tumor antigen binding moiety and a CD16 binding moiety. Also disclosed herein is a method for treating ovarian cancer in a patient in need thereof comprising contacting ovarian cancer cells or gastric cancer cells with memory NK cells in combination with an anti-HER2 monoclonal antibody. Also disclosed herein is a method for treating head and neck cancer or colorectal cancer in a patient in need thereof comprising contacting head and neck cancer cells or colorectal cancer cells with memory NK cells in combination with an anti-EGFR monoclonal antibody. Also disclosed herein is a method for treating urothelial carcinoma, head and neck cancer, colorectal cancer, or gastric cancer cells in a patient in need thereof comprising contacting the cancer cells with memory NK cells in combination with an anti-PDL-1 monoclonal antibody.

Abstract: A method of managing a custom configuration manifest, comprising: collecting by an application configuration selections about a user equipment (UE) that are dynamically configured to create the custom configuration manifest; processing by a server the configuration selections and dynamically configuring the configuration selections to create the manifest; transmitting by the server the manifest to both the UE and a database with a plurality of custom configuration manifests; receiving by a custom configuration manifest handling application authorization through one or more authorization options, but not authentication credentials, to allow the manifest handling application to install preferred applications on the UE; installing by the manifest handling application the preferred applications on the UE without providing the authentication credentials; and customizing by the manifest handling application the UE based on the manifest.

Abstract: A method of managing a custom configuration manifest, comprising: collecting by an application configuration selections about a user equipment (UE) that are dynamically configured to create the custom configuration manifest; processing by a server the configuration selections and dynamically configuring the configuration selections to create the manifest; transmitting by the server the manifest to both the UE and a database with a plurality of custom configuration manifests; receiving by a custom configuration manifest handling application authorization through one or more authorization options, but not authentication credentials, to allow the manifest handling application to install preferred applications on the UE; installing by the manifest handling application the preferred applications on the UE without providing the authentication credentials; and customizing by the manifest handling application the UE based on the manifest.

Abstract: A proxy server for routing traffic between a mobile device and a network, comprising at least one processor, a memory, and a traffic monitoring application stored in the memory that, when executed by the at least one processor, monitors a plurality of mobile device installed applications that run on the mobile device and the mobile device installed applications' traffic, analyzes traffic usage for the mobile device installed applications, identifies the mobile device installed applications responsible for traffic that is excessive or unnecessary as determined by the mobile device's service provider, and blocks, delays, or reports the excessive and unnecessary traffic without interrupting the mobile device's communications.

Abstract: A proxy server for routing traffic between a mobile device and a network, comprising at least one processor, a memory, and a traffic monitoring application stored in the memory that, when executed by the at least one processor, monitors a plurality of mobile device installed applications that run on the mobile device and the mobile device installed applications' traffic, analyzes traffic usage for the mobile device installed applications, identifies the mobile device installed applications responsible for traffic that is excessive or unnecessary as determined by the mobile device's service provider, and blocks, delays, or reports the excessive and unnecessary traffic without interrupting the mobile device's communications.