Patents by Inventor Ryan Patrick LeGraw

Ryan Patrick LeGraw has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genetically engineered human fetal liver niche as platform for biomanufacturing of hematopoietic stem cells
    Patent number: 12692479
    Abstract: The present disclosure relates to methods for expanding populations of hematopoietic stem cells (HSCs) using a genetically engineered human fetal liver niche and compositions of purified ex vivo expanded HSCs. Also provided herein are methods of using such expanded HSC cell populations for clinical applications including allogeneic hematopoietic stem cell transplantation and for drug discovery and modeling human liver development.
    Type: Grant
    Filed: August 12, 2020
    Date of Patent: July 28, 2026
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Mo Reza Ebrahimkhani, Jeremy Velazquez, Samira Kiani, Ryan Patrick LeGraw
  • GENETICALLY ENGINEERED HUMAN FETAL LIVER NICHE AS PLATFORM FOR BIOMANUFACTURING OF HEMATOPOIETIC STEM CELLS
    Publication number: 20220282219
    Abstract: The present disclosure relates to methods for expanding populations of hematopoietic stem cells (HSCs) using a genetically engineered human fetal liver niche and compositions of purified ex vivo expanded HSCs. Also provided herein are methods of using such expanded HSC cell populations for clinical applications including allogeneic hematopoietic stem cell transplantation and for drug discovery and modeling human liver development.
    Type: Application
    Filed: August 12, 2020
    Publication date: September 8, 2022
    Inventors: Mo Reza Ebrahimkhani, Jeremy Velazquez, Samira Kiani, Ryan Patrick LeGraw