Abstract: A delivery device for a collapsible prosthetic heart valve includes an inner shaft, an outer shaft, and a distal sheath. The distal sheath may be disposed distal to the outer shaft and about a portion of the inner shaft to form a compartment with the inner shaft. The compartment may be sized to receive the prosthetic heart valve. The inner shaft and the distal sheath may be movable relative to one another. A spine may extend along the outer shaft, the spine biasing the outer shaft so that the outer shaft tends to bend in a pre-determined direction.

Abstract: A hydraulic system for controlling bleed down and retraction of a boom within a safety envelope includes a backup battery power supply, and at least a first boom lift hydraulic cylinder configured to raise and lower the boom. The first boom lift hydraulic cylinder includes a solenoid bleed valve electrically connected to the backup battery power supply. The hydraulic system also includes an input device controllable by an operator of the boom. The input device may, for instance, be used by the operator to initiate bleed down and retraction of the boom from an elevated position. To accommodate independent failsafe features of the system, the input device is configured to selectively actuate the solenoid bleed valve using electrical power supplied from the backup battery power supply.

Abstract: A system and method are provided for managing digital marketing to a multiplicity of consumers by way of portable wireless digital devices. The system comprises a simplified human-device interface stored on the portable wireless digital devices. An instrumentation subsystem collects interaction and behavioral data from the simplified human-device interface. A campaign management subsystem permits digital marketing content to be made available and the display of content options to be defined to operate in a controlled way. An analytics subsystem processes the interaction and behavioral data in accordance with a knowledge the states of each of the consumers to permit controlling marketing content and promotions to the consumer. A display subsystem stored on the portable wireless digital device controls the display of marketing content and promotions at specific locations within the human-device interface.

Abstract: Usage of the same virtual background during video communications associated with multiple meetings is identified. Common information details in respective information details of the multiple meetings are identified. A virtual background selection rule that associates the common information details of each of the multiple meetings with the same virtual background is automatically generated. A determination is made that information details of a planned meeting matches the common information details. In response to determining that the information details of the planned meeting matches the common information details, the same virtual background of the virtual background selection rule is used for display during the planned meeting.

Abstract: A portable steam generator includes a power source in a housing, a water tank in the housing, a heating element in the housing and configured to heat water in the water tank to produce steam using power from the power source, and a track on the housing configured to support the portable steam generator in an installation position and allow manual removal from the installation position. A pre-plumbed integrated bathroom panel includes a plumbing inlet configured to provide water to the panel, a water outlet connected to the plumbing inlet, a steam outlet connected to the plumbing inlet and a heating element, a sanitizing outlet connected to the plumbing inlet and an additive generator, valves for directing water from the plumbing inlet to the at least one water outlet, the at least one steam outlet, and the at least one sanitizing outlet, and a controller configured to operate at least the plurality of valves.

Abstract: The method performed at an electronic device including one or more processors, a non-transitory memory, and a depth sensor includes: obtaining a task associated with a physical object within a physical environment; obtaining a task associated with a physical object within a physical environment; obtaining depth information, via the depth sensor, associated with the physical environment; determining one or more measurements for the physical object based at least in part on the depth information; generating a graphical overlay for the task based at least in part on the task associated with the physical object and the one or more measurements for the physical object; and causing presentation of the graphical overlay relative to a representation of the physical object, wherein the representation is obtained using sensor readings of the physical object.

Abstract: Provided herein are devices and methods for isolation and detection of an analyte from a sample. In some embodiments, provided herein are devices and methods of use thereof for vertical flow-based isolation and detection of analytes in a liquid sample, such as a urine sample.

Abstract: Various embodiments of a system and method for capturing changes in trade information that impact trade authorization and for updating a chain state on a distributed chain database that is used to authorize trades are disclosed herein. In some embodiments, the system comprises: a trade controller configured to obtain a current state from a local database; a rules engine configured to be invoked by the trade controller to apply a ruleset to data extracted from the local database to generate an updated state; an operation auto detector configured to generate a plan to update a chain state on the distributed chain database based at least in part on the updated state; and an execution engine configured to execute the plan and to generate an updated chain state that is used to authorize trades.

Abstract: Methods and systems provided for determining a phase state and/or for determining a degree of subcooling in a fluid. An exemplary method for operating a refrigeration cycle includes flowing a refrigerant through a metering device and calculating a pressure differential of the refrigerant across the metering device. Further, the method includes determining whether the refrigerant is a saturated liquid based on the pressure differential. The method includes, when the refrigerant is not a saturated liquid, cooling the refrigerant upstream of the metering device.

Abstract: Systems and methods are provided for creating and executing a decision network that includes a number of stations configured to operate with respect to an instance of a document, container or other object. A user interface may be presented to a user that includes selectable options for configuring and connecting stations within the decision network, and for establishing executable logic for each station to modify or create data within fields of a container instance. Different stations in the decision network may be assigned different permissions with respect to the container. Individual stations in the decision network may be configured to determine a prediction or probability based on data accessible to the given station, where the prediction or probability of one station may be based in part on an earlier prediction or probability determined at another station of the decision network.

Abstract: An armrest center console for a vehicle includes a housing defining a storage bin, a track assembly having a first and second tracks provided on opposite sides of the housing, and an armrest cover assembly supported on the housing and having a deployable table. The armrest center console also includes a linkage assembly coupling the armrest cover assembly to the first and second tracks, wherein the armrest cover assembly is configured to slide forward on the first and second rail and to rotate upward via the linkage assembly to deploy the deployable table.

Abstract: In various embodiments method are provided for generating expression cassettes and gene therapy vectors comprising those cassettes that recapitulate the spatiotemporal pattern of expression of the endogenous gene. In certain embodiments the methods comprise (i) selecting a target gene; (ii) identifying putative regulatory elements associated with the target gene; (iii) determining if the regulatory element is a key regulatory element and (iv) providing a list of the key regulatory elements identified in step (iii).

Abstract: A delivery device for a collapsible prosthetic heart valve includes an inner shaft, an outer shaft, and a distal sheath. The distal sheath may be disposed distal to the outer shaft and about a portion of the inner shaft to form a compartment with the inner shaft. The compartment may be sized to receive the prosthetic heart valve. The inner shaft and the distal sheath may be movable relative to one another. A spine may extend along the outer shaft, the spine biasing the outer shaft so that the outer shaft tends to bend in a pre-determined direction.

Abstract: A clamp apparatus is used for securing one end of a flexible sheet spanning under tension across a building opening relative to a perimeter beam along the edge of the building opening. The clamp apparatus has a C-shaped channel body having (i) a first flange with a threaded bore therein to receive a bolt defining a first clamping jaw and (ii) a second flange defining an opposing second clamping jaw, whereby the clamp apparatus clamps a perimeter mounted flange of the flexible sheet onto a beam flange of the perimeter beam. C-shaped stiffener plates are mounted externally on the channel body, spaced apart from one another along the length of the channel body in perpendicular relation to the length to reinforce the clamp such that the clamp is able to withstand high wind forces acting on the tensioned sheet.

Abstract: A tool interchange for a submersible remote operated vehicle (ROV) arm includes a first interchange body that affixes to an ROV arm. A second interchange body is carried by the first interchange body to rotate on a rotation axis. The second interchange body includes a tool mount actuable between gripping an ROV tool to the second interchange body and releasing the ROV tool from the second interchange body. An inductive power coupling part is provided in the tool mount. The inductive power coupling part is presented outwardly in the tool mount opposite the first interchange body, resides on the rotation axis and is fixed with respect to the first interchange body while the second interchange body rotates. The inductive power coupling part is adapted to inductively communicate power with a corresponding inductor power coupling part of the ROV tool when the ROV tool is docked in the tool mount.

Abstract: Elements formed from magnetic materials and their methods of manufacture are presented. Magnetic materials include a magnetic alloy material, such as, for example, an Fe-Co alloy material (e.g., the Fe-Co-V alloy Hiperco-50(R)). The magnetic alloy materials may comprise a powdered material suitable for use in additive manufacturing techniques, such as, for example direct energy deposition or laser powder bed fusion. Manufacturing techniques include the use of variable deposition time and energy to control the magnetic and structural properties of the materials by altering the microstructure and residual stresses within the material. Manufacturing techniques also include post deposition processing, such as, for example, machining and heat treating. Heat treating may include a multi-step process during which the material is heated, held and then cooled in a series of controlled steps such that a specific history of stored internal energy is created within the material.

Abstract: A computing device facilitates selection of (i) a data-object currency for a data object of a construction project and (ii) an exchange rate for converting between the data-object currency and a project currency. Based on project-level currency settings and permissions information, currency options from which a given user is permitted to select a data-object currency for the data object are identified and presented for selection. After selection of the data-object currency, based on the permissions information and information about the data object, exchange rate options from which the given user is permitted to select an exchange rate for converting between the data-object currency and the project currency are identified and presented for selection. After selection of the exchange rate, cost values for line items of the data object are converted from the data-object currency to the project currency using the exchange rate and dynamically updated based on cost value modifications.

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: A tip valve and a cook system incorporating same that automatically stops the flow of gas to a burner when tipped over and that automatically resets when disconnected from the fuel canister to allow the flow of gas to resume when righted and reconnected are provided. The tip valve includes a ball bearing freely moveable between a fuel canister actuator pin and a tip seal within a bore having two different diameters at each end thereof. The transition between the two diameters forms a taper that may be continuous forming a smooth tapered bore, or discontinuous formed by at least one counter bore. The automatic resetting is provided without the use of a mechanical pin or member.