Patents by Inventor Ryan Paul
Ryan Paul has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250236631Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S, G13D, Q61H, Q61L or G12C. The compounds have a general Formula I?: wherein the variables of Formula I? are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.Type: ApplicationFiled: April 11, 2025Publication date: July 24, 2025Applicant: AMGEN INC.Inventors: Ryan Paul Wurz, Yunxiao LI, Primali Vasundera NAVARATNE, Jose M. MEDINA, Ning CHEN, Liping PETTUS, Xiaofen LI, John STELLWAGEN, Kexue LI, Brian Alan LANMAN, Michael M. YAMANO, Wei ZHAO, Benjamin WIGMAN, Fabien EMMETIERE, Albert K. AMEGADZIE, Christopher P. MOHR, Aaron C. SIEGMUND, Rene RAHIMOFF, Zhichen WU, Adriano BAUER, Andrew SMALIGO, Quentin Tercenio, Qingyian Liu, Shon K. Booker, Jeffrey Jackson
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Publication number: 20250179077Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S or G12C. The compounds have a general Formula (I): (Formula (I)) wherein the variables of Formula (I) are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.Type: ApplicationFiled: February 15, 2023Publication date: June 5, 2025Applicant: AMGEN INC.Inventors: Brian Alan Lanman, Ryan Paul Wurz, Wei Zhao, Xiaofen LI, Imelda HOT, Rene RAHIMOFF, Liping Pettus, Ning Chen, Fabien EMMETIERE, Jeffery Jackson, Yunxiao LI, Francesco Manoni, Primali Navaratne, Andrew Smaligo, John Charles Stellwagen, John Allen
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Publication number: 20250163064Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S or G12C. The compounds have a general Formula I: (I) wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.Type: ApplicationFiled: February 15, 2023Publication date: May 22, 2025Applicant: AMGEN INC.Inventors: Brian Alan Lanman, Ryan Paul Wurz, Wei Zhao, Xiaofen LI, Michael YAMANO, Imelda HOT, Rene RAHIMOFF, Liping Pettus, Jose Medina
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Patent number: 12293339Abstract: A cashless gaming method including receiving payment for a selected gaming ticket having a predefined fixed value, the gaming ticket being redeemable at a cashless-enabled gaming machine for an associated amount of wagerable credits, and issuing the fixed value gaming ticket to the player responsive to receiving the payment.Type: GrantFiled: July 18, 2022Date of Patent: May 6, 2025Assignee: Aristocrat Technologies Australia Pty LimitedInventor: Ryan Paul Hawkins
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Publication number: 20250123069Abstract: Trigger groups for striker-fired firearms have a firing pin assembly connected to a slide and operable to reciprocate between a rearward retracted position and a forward extended position, the firing pin assembly including a retention surface, a trigger assembly including a sear surface configured to selectively engage the retention surface to releasably restrain the firing pin assembly, the firing pin assembly being responsive to the trigger assembly to release from the retracted position to the extended position in response to movement of the trigger assembly from the forward trigger position to the rearward trigger position and to release from the retracted position to the extended position in response to movement of the trigger assembly from the rearward trigger position to the forward trigger position, the trigger assembly including a retainer movable between a clear position and a blocking position.Type: ApplicationFiled: December 19, 2024Publication date: April 17, 2025Applicant: Franklin Armory Holdings, Inc.Inventor: Ryan Paul Fellows
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Publication number: 20250125614Abstract: A micro grid system comprises a secondary energy source and a power controller. The secondary energy source is associated with a micro grid that includes a fixed or mobile facility, and the secondary energy source is configured to generate first DC power signal. The power controller is in communication with the secondary energy source and an electric grid, and configured to receive first AC power signal from the electric grid and the first DC power signal from the secondary energy source and output a second AC power signal to loads in communication with the power controller. The power controller comprises an AC to DC frequency converter configured to change frequency and/or voltage of the second AC power signal, a processor, and a memory configured to store instructions that, when executed, cause the processor to control the frequency converter to change the frequency and/or voltage of the second AC power signal.Type: ApplicationFiled: June 4, 2024Publication date: April 17, 2025Inventors: Paul W. Donahue, Ryan Paul Donahue, Jeffrey Alan Dankworth
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Publication number: 20250122222Abstract: The present disclosure provides compounds useful for the inhibition of KRAS. The compounds have a general Formula I: wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.Type: ApplicationFiled: August 10, 2022Publication date: April 17, 2025Applicant: AMGEN INC.Inventors: Michael M. YAMANO, Yunxiao LI, Primali Vasundera NAVARATNE, Jose M. MEDINA, Ning CHEN, Liping PETTUS, Rene RAHIMOFF, Xiaofen LI, John STELLWAGEN, Francesco MANONI, Kexue LI, Brian Alan LANMAN, Ryan Paul Wurz, Wei ZHAO, Huan RUI, Josephine ESHON
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Publication number: 20250125613Abstract: A microgrid comprises a meter adapter for interconnection to the electric grid, facility loads, and renewable energy resources using connectors, bus bars, and switches. Adapter connectors and internal bus bars and can be stressed with excessive heat rise from heat losses that arise from carrying high currents due to constraints in the physical size and airflow restrictions. Exhaust ports and/or vents are arranged to achieve a chimney cooling effect in such conditions to meet stringent UL requirements against resultant heat rise within a meter adapter.Type: ApplicationFiled: May 22, 2024Publication date: April 17, 2025Inventors: Paul W. Donahue, Ryan Paul Donahue, Jeffrey Alan Dankworth
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Patent number: 12247786Abstract: A system including a graphite electrode having a graphite body with first and second opposed ends. The electrode further includes a threaded connector positioned at one of the first or second ends, and a tag coupled to or positioned in the threaded connector, wherein the tag is configured to transmit a signal including information relating to the electrode.Type: GrantFiled: October 6, 2022Date of Patent: March 11, 2025Assignee: GrafTech International Holdings Inc.Inventors: Pablo Toniolo, Ronald Gerhan, Ryan Paul, James Merzlak, Frank Andrew Messineo, Jr.
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Publication number: 20250059205Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D. The compounds have a general Formula I: (I) wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.Type: ApplicationFiled: April 28, 2022Publication date: February 20, 2025Applicant: AMGEN INC.Inventors: Brian Alan Lanman, Ryan Paul Wurz, Wei Zhao, Xiaofen Li, Michael M. Yamano, Yunxiao Li, Ning Chen, Birgitte Weinreich Husemoen, Sebastian Leth-Petersen, Jose M. Medina, Kexue Li, Liping Pettus, Rene Rahimoff, Primali Vasundera Navaratne, Huan Rui, Christopher P. Mohr
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Publication number: 20250059179Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D. The compounds have a general Formula I: (I) wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.Type: ApplicationFiled: April 28, 2022Publication date: February 20, 2025Applicant: AMGEN INC.Inventors: Brian Alan Lanman, Ryan Paul Wurz, Wei Zhao, Xiaofen Li, Michael M. Yamano, Yunxiao Li, Ning Chen, Sebastian Leth-Petersen, Kexue Li, Liping Pettus, Rene Rahimoff, Primali Vasundera Navaratne, Huan Rui
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Publication number: 20250034167Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D. The compounds have a general Formula (I): wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.Type: ApplicationFiled: August 10, 2022Publication date: January 30, 2025Applicant: AMGEN INC.Inventors: Michael M. YAMANO, Yunxiao LI, Primali Vasundera NAVARATNE, Jose M. MEDINA, Ning CHEN, Liping PETTUS, Rene RAHIMOFF, Xiaofen LI, John STELLWAGEN, Francesco MANONI, Kexue LI, Brian Alan LANMAN, Ryan Paul Wurz, Wei ZHAO, Huan RUI, Josephine ESHON
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Patent number: 12209827Abstract: Trigger groups for striker-fired firearms have a firing pin assembly connected to a slide and operable to reciprocate between a rearward retracted position and a forward extended position, the firing pin assembly including a retention surface, a trigger assembly including a sear surface configured to selectively engage the retention surface to releasably restrain the firing pin assembly, the firing pin assembly being responsive to the trigger assembly to release from the retracted position to the extended position in response to movement of the trigger assembly from the forward trigger position to the rearward trigger position and to release from the retracted position to the extended position in response to movement of the trigger assembly from the rearward trigger position to the forward trigger position, the trigger assembly including a retainer movable between a clear position and a blocking position.Type: GrantFiled: March 28, 2023Date of Patent: January 28, 2025Assignee: FRANKLIN ARMORY HOLDINGS, INC.Inventor: Ryan Paul Fellows
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Patent number: 12186731Abstract: The present disclosure is directed to metal organic framework materials and uses for such metal organic framework materials. According to one embodiment, a metal organic framework material may include zinc ions, one or more triazoles, and one or more imidazoles. At least a portion of the zinc ions may be coordinated by the triazoles and the imidazoles such that at least a portion of the metal organic framework material forms a crystalline structure belonging to a monoclinic crystal system.Type: GrantFiled: August 28, 2020Date of Patent: January 7, 2025Assignee: Georgia Tech Research CorporationInventors: Richelle Lyndon, Ryan Paul Lively, David Scott Sholl, Wenqin You
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Patent number: 12182608Abstract: Systems and methods for implementing an automation platform that is configured to analyze computing activities from a plurality of users so as to identify potential automation processes is provided. In one or more examples, a plurality of data collection agents are deployed across a plurality of computing devices and can be configured to collect and record activities performed on the computing device by one or more users of the computing devices. In one or more examples, each agent deployed on a computing device can be configured to transmit the collected data to a central server that can store the collected data in memory. The central server can be configured to collect the data from each agent and can be configured to apply one or more data science algorithms that can be configured to cluster various activities collected by the agents into groups for potential automation.Type: GrantFiled: August 5, 2021Date of Patent: December 31, 2024Assignee: PwC Product Sales LLCInventors: Shabbir Hussamuddin Alibhai, Ryan Paul Beechey, Joseph Michael Engel, Christopher Ryan Tucci, Thomas Joseph Foth, Antoinette L. Young
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Publication number: 20240418468Abstract: Pistols having a plurality of operating conditions have a frame having a trigger, an elongated slide connected to the frame and having a rear end facing a user, a moving control element on the elongated slide and positioned in a first position when the pistol is in a first operating condition, and positioned in a second condition when the pistol is in a second operating condition, an indicator on the moving control element visible to the rear, indicia on the elongated slide having a first element associated with the first operating condition and a second element associated with the second operating condition, and the indicator being registered with the first element of the indicia when the moving control element is in the first position, and the indicator being registered with the second element of the indicia when the moving control element is in the second position.Type: ApplicationFiled: August 19, 2024Publication date: December 19, 2024Applicant: Franklin Armory Holdings, Inc.Inventors: Joseph Harrison Haas, Ryan Paul Fellows
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Publication number: 20240417412Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D. The compounds have a general Formula I: wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.Type: ApplicationFiled: August 10, 2022Publication date: December 19, 2024Applicant: AMGEN INC.Inventors: Brian Alan Lanman, Wei Zhao, Ryan Paul Wurz, Primali Vasundera NAVARATNE, Liping PETTUS, Michael M. YAMANO, Ning Chen, Rene RAHIMOFF, Francesco MANONI, John STELLWAGEN
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Publication number: 20240404373Abstract: The present invention relates to gaming machines, systems and methods of gaming. There are a number of different ways available for determining an award by current gaming machines and systems. In this embodiment, a game controller is arranged to determine an award depending on the number of columns spanned by a cluster of symbols and the number of symbol positions in the cluster.Type: ApplicationFiled: August 9, 2024Publication date: December 5, 2024Inventors: Ryan Paul Hawkins, Yanis Tsombanidis, Stephanie Johns, Robert Honeycutt
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Publication number: 20240333789Abstract: Systems and methods for providing a seamless automatic repeat request (ARQ) stream are provided. The system can include a plurality of streaming servers, a load balancer, and an ARQ streaming service. The ARQ streaming service obtains encoded content segments and transmits the segments to a plurality of streaming servers. The plurality of streaming servers is configured to transmit the encoded content segments to a client computing device, and a load balancer is implemented between the client computing device and the plurality of streaming servers. When the client computing device sends a response message to the ARQ streaming service while receiving the encoded content segments from one of the plurality of streaming servers, the ARQ streaming service may identify a failure in the streaming server. The ARQ streaming service retransmits lost encoded content segments by switching the streaming path to another streaming server from the plurality of streaming servers.Type: ApplicationFiled: March 30, 2023Publication date: October 3, 2024Inventors: Evan Gerald Statton, Bryan Michael Samis, Michael Henry, Ryan Paul Hegar, Sydney Dean Lovely
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Publication number: 20240314187Abstract: A video packaging and origination service can include one or more encoder components that receive content for encoding and transmitting to requesting entities. During the operation of the encoder components, a management service associated with the video packaging and origination service can receive information related to updates or modifications to the encoder components. Responsive to the information, the management service can instantiate and configure an updated encoder. Once the updated encoder component is instantiated and configured, both the updated and target encoder components receive content for streaming, encode content and generating encoding content. Additionally, the updated encoder component can initiate a notification to the target encoder component that a handover will be occurring and begin a negotiation process identifying a handover event.Type: ApplicationFiled: May 21, 2024Publication date: September 19, 2024Inventors: Eric Woodruff, Ryan Paul Hegar, Khawaja Salman Shams