Patents by Inventor Ryan PHILIPPE

Ryan PHILIPPE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240215615
    Abstract: The invention provides methods for making steviol glycosides, including RebM and glycosylation products that are minor products in stevia leaves, and provides enzymes, encoding polynucleotides, and host cells for use in these methods. The invention provides engineered enzymes and engineered host cells for producing steviol glycosylation products, such as RebM, at high purity and/or yield. The invention further provides methods of making products containing steviol glycosides, such as RebM, including food products, beverages, oral care products, sweeteners, and flavoring products.
    Type: Application
    Filed: September 14, 2023
    Publication date: July 4, 2024
    Inventors: Ryan PHILIPPE, Ajikumar Parayil KUMARAN, Jason DONALD, Krishna PATEL, Swati GUPTA, Ryan LIM, Liwei LI
  • Publication number: 20230146484
    Abstract: The present invention provides engineered cells and methods for making high purity steviol glycosides, including RebM. In some aspects, the present invention provides host cells, such as bacterial cells (including but not limited to E. coli), that are engineered to overexpress and/or delete or inactivate one or more steviol glycoside transport proteins. The bacterial cells selectively export RebM, or other specific combination of steviol glycosides, out of the cell to increase productivity and reduce production costs associated with downstream purification. Non-target steviol glycosides are not transported to the extracellular medium in significant amounts.
    Type: Application
    Filed: November 7, 2022
    Publication date: May 11, 2023
    Inventors: Ryan PHILIPPE, Ajikumar PARAYIL KUMARAN, Christine Nicole S. SANTOS
  • Publication number: 20220364127
    Abstract: In various aspects and embodiments, the invention relates to bacterial strains and methods for making terpene and terpenoid products. The invention provides bacterial strains with improved carbon flux through the MEP pathway, to thereby increase terpene and/or terpenoid product yield by fermentation with carbon sources such as glucose.
    Type: Application
    Filed: April 26, 2022
    Publication date: November 17, 2022
    Inventors: Ajikumar Parayil KUMARAN, Chin-Giaw LIM, Souvik GHOSH, Christopher PIRIE, Jason DONALD, Aaron LOVE, Hong NAN, Hsien-Chung TSENG, Christine Nicole S. SANTOS, Ryan PHILIPPE
  • Publication number: 20220251607
    Abstract: The invention relates to methods and bacterial strains for making terpene and terpenoid products, the bacterial strains having improved carbon pull through the MEP pathway and to a downstream recombinant synthesis pathway.
    Type: Application
    Filed: April 26, 2022
    Publication date: August 11, 2022
    Inventors: Ajikumar Parayil KUMARAN, Ryan LIM, Jason DONALD, Hsien-Chung TSENG, Christine Nicole S. SANTOS, Ryan PHILIPPE
  • Publication number: 20210032669
    Abstract: The present invention provides host cells and methods for making mogrol glycosides, including Mogroside V (Mog. V), Mogroside VI (Mog. VI), Iso-Mogroside V (Isomog. V), and glycosylation products that are minor products in Siraitia grosvenorii. The invention provides engineered enzymes and engineered host cells for producing mogrol glycosylation products, such as Mog, V. Mog. VI, and Isomog. V, at high purity and/or yield. The present technology further provides methods of making products containing mogrol glycosides, such as Mog. V, Mog. VI, and Isomog. V, including food products, beverages, oral care products, sweeteners, and flavoring products.
    Type: Application
    Filed: February 27, 2019
    Publication date: February 4, 2021
    Inventors: Ryan PHILIPPE, Ajikumar Parayil KUMARAN, Christine Nicole S. SANTOS, Michelle N. GOETTGE
  • Publication number: 20210022373
    Abstract: The invention provides methods for making steviol glycosides, including RebM and glycosylation products that are minor products in stevia leaves, and provides enzymes, encoding polynucleotides, and host cells for use in these methods. The invention provides engineered enzymes and engineered host cells for producing steviol glycosylation products, such as RebM, at high purity and/or yield. The invention further provides methods of making products containing steviol glycosides, such as RebM, including food products, beverages, oral care products, sweeteners, and flavoring products.
    Type: Application
    Filed: April 29, 2020
    Publication date: January 28, 2021
    Inventors: Ryan PHILIPPE, Ajikumar Parayil KUMARAN, Jason DONALD, Krishna PATEL, Swati GUPTA, Ryan LIM, Liwei LI
  • Publication number: 20210002672
    Abstract: The invention relates to methods and bacterial strains for making terpene and terpenoid products, the bacterial strains having improved carbon pull through the MEP pathway and to a downstream recombinant synthesis pathway.
    Type: Application
    Filed: August 13, 2020
    Publication date: January 7, 2021
    Inventors: Ajikumar Parayil KUMARAN, Ryan LIM, Jason DONALD, Hsien-Chung TSENG, Christine Nicole S. SANTOS, Ryan PHILIPPE
  • Publication number: 20200347425
    Abstract: The present invention provides engineered cells and methods for making high purity steviol glycosides, including RebM. In some aspects, the present invention provides host cells, such as bacterial cells (including but not limited to E. coli), that are engineered to overexpress and/or delete or inactivate one or more steviol glycoside transport proteins. The bacterial cells selectively export RebM, or other specific combination of steviol glycosides, out of the cell to increase productivity and reduce production costs associated with downstream purification. Non-target steviol glycosides are not transported to the extracellular medium in significant amounts.
    Type: Application
    Filed: November 15, 2018
    Publication date: November 5, 2020
    Inventors: Ryan PHILIPPE, Ajikumar Parayil KUMARAN, Christine Nicole S. SANTOS
  • Publication number: 20200299735
    Abstract: In various aspects and embodiments, the invention relates to bacterial strains and methods for making terpene and terpenoid products. The invention provides bacterial strains with improved carbon flux through the MEP pathway, to thereby increase terpene and/or terpenoid product yield by fermentation with carbon sources such as glucose.
    Type: Application
    Filed: April 29, 2020
    Publication date: September 24, 2020
    Inventors: Ajikumar Parayil KUMARAN, Chin-Giaw LIM, Souvik GHOSH, Christopher PIRIE, Jason DONALD, Aaron LOVE, Hong NAN, Hsien-Chung TSENG, Christine Nicole S. SANTOS, Ryan PHILIPPE
  • Publication number: 20200002733
    Abstract: The invention relates to methods and bacterial strains for making terpene and terpenoid products, the bacterial strains having improved carbon pull through the MEP pathway and to a downstream recombinant synthesis pathway.
    Type: Application
    Filed: September 13, 2019
    Publication date: January 2, 2020
    Inventors: Ajikumar Parayil KUMARAN, Ryan LIM, Jason DONALD, Hsien-Chung TSENG, Christine Nicole S. SANTOS, Ryan PHILIPPE
  • Publication number: 20190269157
    Abstract: The invention provides methods for making steviol glycosides, including RebM and glycosylation products that are minor products in stevia leaves, and provides enzymes, encoding polynucleotides, and host cells for use in these methods. The invention provides engineered enzymes and engineered host cells for producing steviol glycosylation products, such as RebM, at high purity and/or yield. The invention further provides methods of making products containing steviol glycosides, such as RebM, including food products, beverages, oral care products, sweeteners, and flavoring products.
    Type: Application
    Filed: January 18, 2019
    Publication date: September 5, 2019
    Inventors: Ryan PHILIPPE, Ajikumar Parayil KUMARAN, Jason DONALD, Krishna PATEL, Swati GUPTA, Ryan LIM, Liwei LI
  • Publication number: 20180245103
    Abstract: In various aspects and embodiments, the invention relates to bacterial strains and methods for making terpene and terpenoid products. The invention provides bacterial strains with improved carbon flux through the MEP pathway, to thereby increase terpene and/or terpenoid product yield by fermentation with carbon sources such as glucose.
    Type: Application
    Filed: February 5, 2018
    Publication date: August 30, 2018
    Inventors: Ajikumar Parayil KUMARAN, Chin-Giaw LIM, Souvik GHOSH, Christopher PIRIE, Jason DONALD, Aaron LOVE, Hong NAN, Hsien-Chung TSENG, Christine Nicole S. SANTOS, Ryan PHILIPPE
  • Publication number: 20180216137
    Abstract: The invention relates to methods and bacterial strains for making terpene and terpenoid products, the bacterial strains having improved carbon pull through the MEP pathway and to a downstream recombinant synthesis pathway.
    Type: Application
    Filed: January 26, 2018
    Publication date: August 2, 2018
    Inventors: Ajikumar Parayil KUMARAN, Ryan LIM, Jason DONALD, Hsien-Chung TSENG, Christine SANTOS, Ryan PHILIPPE
  • Publication number: 20170332673
    Abstract: The invention provides methods for making steviol glycosides, including RebM and glycosylation products that are minor products in stevia leaves, and provides enzymes, encoding polynucleotides, and host cells for use in these methods. The invention provides engineered enzymes and engineered host cells for producing steviol glycosylation products, such as RebM, at high purity and/or yield. The invention further provides methods of making products containing steviol glycosides, such as RebM, including food products, beverages, oral care products, sweeteners, and flavoring products.
    Type: Application
    Filed: November 5, 2015
    Publication date: November 23, 2017
    Inventors: Ryan PHILIPPE, Ajikumar Parayil KUMARAN, Jason DONALD, Krishna PATEL, Swati GUPTA, Ryan LIM, Liwei LI