Abstract: Disclosed herein are bispecific aptamers having affinity for multiple ligands and in particular, VEGF, IL8 and Ang2, as well as pharmaceutical compositions comprising the same. Methods of using some bispecific aptamers for the treatment of retinal diseases and disorders are also disclosed, as well as methods of making such bispecific aptamers and compositions.

Abstract: This disclosure describes systems and methods for employing interlinking multiple independent and separately-scalable blockchains to create globally verifiable unique identifiers. The disclosed systems and methods facilitate the creation of the globally verifiable unique identifiers to a level of scalability unattainable without employing the underlying two-dimensional blockchain structure, metadata, and cryptographic information stored on the blockchain. Moreover, the system avoids collisions and name conflicts among the globally verifiable unique identifiers, supports post-creation verification of the globally verifiable unique identifiers, and provides a variety of ancillary functions using the globally verifiable unique identifiers.

Abstract: This disclosure describes systems and methods for employing interlinking multiple independent and separately-scalable blockchains to create globally verifiable unique identifiers. The disclosed systems and methods facilitate the creation of the globally verifiable unique identifiers to a level of scalability unattainable without employing the underlying two-dimensional blockchain structure, metadata, and cryptographic information stored on the blockchain. Moreover, the system avoids collisions and name conflicts among the globally verifiable unique identifiers, supports post-creation verification of the globally verifiable unique identifiers, and provides a variety of ancillary functions using the globally verifiable unique identifiers.

Abstract: This disclosure describes systems and methods for interlinking multiple independent and separately-scalable blockchains to provide transactional provenance. The disclosed systems and methods leverage a combination of blockchain and graph data structures to interoperate between blockchains without requiring a single data structure while still providing a single chain of custody and provenance for a particular set of actions.

Abstract: This disclosure describes systems and methods for interlinking multiple independent and separately-scalable blockchains to provide transactional provenance. The disclosed systems and methods leverage a combination of blockchain and graph data structures to interoperate between blockchains without requiring a single data structure while still providing a single chain of custody and provenance for a particular set of actions.

Abstract: This disclosure describes systems and methods for employing interlinking multiple independent and separately-scalable blockchains to create globally verifiable unique identifiers. The disclosed systems and methods facilitate the creation of the globally verifiable unique identifiers to a level of scalability unattainable without employing the underlying two-dimensional blockchain structure, metadata, and cryptographic information stored on the blockchain. Moreover, the system avoids collisions and name conflicts among the globally verifiable unique identifiers, supports post-creation verification of the globally verifiable unique identifiers, and provides a variety of ancillary functions using the globally verifiable unique identifiers.

Abstract: This disclosure describes systems and methods for employing interlinking multiple independent and separately-scalable blockchains to create globally verifiable unique identifiers. The disclosed systems and methods facilitate the creation of the globally verifiable unique identifiers to a level of scalability unattainable without employing the underlying two-dimensional blockchain structure, metadata, and cryptographic information stored on the blockchain. Moreover, the system avoids collisions and name conflicts among the globally verifiable unique identifiers, supports post-creation verification of the globally verifiable unique identifiers, and provides a variety of ancillary functions using the globally verifiable unique identifiers.

Abstract: This disclosure describes systems and methods for employing interlinking multiple independent and separately-scalable blockchains to create globally verifiable unique identifiers. The disclosed systems and methods facilitate the creation of the globally verifiable unique identifiers to a level of scalability unattainable without employing the underlying two-dimensional blockchain structure, metadata, and cryptographic information stored on the blockchain. Moreover, the system avoids collisions and name conflicts among the globally verifiable unique identifiers, supports post-creation verification of the globally verifiable unique identifiers, and provides a variety of ancillary functions using the globally verifiable unique identifiers.

Abstract: This disclosure describes systems and methods for interlinking multiple independent and separately-scalable blockchains to provide transactional provenance. The disclosed systems and methods leverage a combination of blockchain and graph data structures to interoperate between blockchains without requiring a single data structure while still providing a single chain of custody and provenance for a particular set of actions.

Abstract: Devices, systems and/or methods are provided to implement true real time pattern recognition and anomaly detection by leveraging hardware specifically designed for that purpose. In particular, digital signal processors (DSPs) are used to provide true real time analysis of digital signals. In an embodiment, the system may convert the CEP stream itself to a format understood by the hardware components while retaining enough specificity to reference particular events for further processing and analytics, resulting in true real time performance for CEP.

Abstract: According to one aspect of the invention, there is provided a method to facilitate generating listing recommendations to a user of a network-based commerce system. In one embodiment, the method includes identifying a term associated with a user interaction in a network-based commerce system. The method further includes generating a recommendation query including the identified term. In addition, the method includes running the recommendation query against a plurality of listings hosted by the network-based commerce system to identify a recommendation. Moreover, the method includes presenting the recommendation to a user of the network-based commerce system.

Abstract: A method and a system for delivering certified messages to message servers are provided. In example embodiments, a message request including message information may be received from an application. The message information may identify a message template in a message template database using an identifier comprising multiple fields. The message information may be sent in a certified message to a queuing system for storage in a data store. A confirmation that the message information has been stored in the data store may be sent to the application.

Abstract: According to one aspect of the invention, there is provided a method to facilitate generating listing recommendations to a user of a network-based commerce system. In one embodiment, the method includes identifying a term associated with a user interaction in a network-based commerce system. The method further includes generating a recommendation query including the identified term. In addition, the method includes running the recommendation query against a plurality of listings hosted by the network-based commerce system to identify a recommendation. Moreover, the method includes presenting the recommendation to a user of the network-based commerce system.

Abstract: According to one aspect of the invention, there is provided a method to facilitate generating listing recommendations to a user of a network-based commerce system. In one embodiment, the method includes identifying a term associated with a user interaction in a network-based commerce system. The method further includes generating a recommendation query including the identified term. In addition, the method includes running the recommendation query against a plurality of listings hosted by the network-based commerce system to identify a recommendation. Moreover, the method includes presenting the recommendation to a user of the network-based commerce system.

Abstract: According to one aspect of the invention, there is provided a method to facilitate generating listing recommendations to a user of a network-based commerce system. In one embodiment, the method includes identifying a term associated with a user interaction in a network-based commerce system. The method further includes generating a recommendation query including the identified term. In addition, the method includes running the recommendation query against a plurality of listings hosted by the network-based commerce system to identify a recommendation. Moreover, the method includes presenting the recommendation to a user of the network-based commerce system.

Abstract: A method and a system for delivering certified messages to message servers are provided. In example embodiments, a message request including message information may be received from an application. The message information may identify a message template in a message template database using an identifier comprising multiple fields. The message information may be sent in a certified message to a queuing system for storage in a data store. A confirmation that the message information has been stored in the data store may be sent to the application.

Abstract: A message database server receives a message request from an application program and returns a confirmation or error status to the application program after attempting to store the message information contained in the request to a data store. The data store may be maintained by the message database server or by a queuing system. A message server obtains the message information from the data store for transmission through either a pull or push methodology. In one aspect the message data store contains a set of personalization tags and an identifier for a message template that contains the text of the message to be sent. The message server creates the message by retrieving the message template specified by the identifier and filling in variables in the text in the template with the appropriate personalization tags.

Abstract: According to one aspect of the invention, there is provided a method to facilitate generating listing recommendations to a user of a network-based commerce system. In one embodiment, the method includes identifying a term associated with a user interaction in a network-based commerce system. The method further includes generating a recommendation query including the identified term. In addition, the method includes running the recommendation query against a plurality of listings hosted by the network-based commerce system to identify a recommendation. Moreover, the method includes presenting the recommendation to a user of the network-based commerce system.

Abstract: A message database server receives a message request from an application program and returns a confirmation or error status to the application program after attempting to store the message information contained in the request to a data store. The data store may be maintained by the message database server or by a queuing system. A message server obtains the message information from the data store for transmission through either a pull or push methodology. In one aspect the message data store contains a set of personalization tags and an identifier for a message template that contains the text of the message to be sent. The message server creates the message by retrieving the message template specified by the identifier and filling in variables in the text in the template with the appropriate personalization tags.