Abstract: In various embodiments method are provided for generating expression cassettes and gene therapy vectors comprising those cassettes that recapitulate the spatiotemporal pattern of expression of the endogenous gene. In certain embodiments the methods comprise (i) selecting a target gene; (ii) identifying putative regulatory elements associated with the target gene; (iii) determining if the regulatory element is a key regulatory element and (iv) providing a list of the key regulatory elements identified in step (iii).

Abstract: A method and system for a platform wide party system that may be deployed in a multiplayer gaming environment. Players may associate themselves with one or more parties, wherein players within a party may choose to automatically exchange messages associated with changes in state of the players in a gaming environment. The party system exposes an API providing a plurality of function calls that may be integrated seamlessly with game play. A first player may indicate desired notification events to be received from a second player associated with the same party as the first player. Upon detection of a desired notification event on the video game console of the second player, an event notification may be communicated to a video game console of the first player causing an action to be performed on the first player's video game console.

Abstract: A method and system for a platform wide party system that may be deployed in a multiplayer gaming environment. Players may associate themselves with one or more parties, wherein players within a party may choose to automatically exchange messages associated with changes in state of the players in a gaming environment. The party system exposes an API providing a plurality of function calls that may be integrated seamlessly with game play. A first player may indicate desired notification events to be received from a second player associated with the same party as the first player. Upon detection of a desired notification event on the video game console of the second player, an event notification may be communicated to a video game console of the first player causing an action to be performed on the first player's video game console.

Abstract: A method and system for a platform wide party system that may be deployed in a multiplayer gaming environment. Players may associate themselves with one or more parties, wherein players within a party may choose to automatically exchange messages associated with changes in state of the players in a gaming environment. The party system exposes an API providing a plurality of function calls that may be integrated seamlessly with game play. A first player may indicate desired notification events to be received from a second player associated with the same party as the first player. Upon detection of a desired notification event on the video game console of the second player, an event notification may be communicated to a video game console of the first player causing an action to be performed on the first player's video game console.