Abstract: A device for penetrating tissue with reduced force and placing a guidewire is provided. The device includes a driving actuator generating reciprocating motion. A penetrating member having a lumen dimensioned to accommodate a guidewire is provided. A coupler mechanically connects the driving actuator and the penetrating member to transfer the reciprocating motion to the penetrating member. The penetrating member may be coaxial or axially offset from the driving actuator. At least one frictional member facilitates the movement of the guidewire through the lumen for placement at the target tissue. The frictional member(s) may be operated manually or by a guidewire actuator. A housing may also be provided including a channel also dimensioned to accommodate the guidewire, and may further include the frictional member(s) for facilitating movement of the guidewire. The channel and lumen are aligned to permit placement of the guidewire at the target site.

Abstract: An occlusion clearing device for a patient has a housing with a motor(s) that generates repetitive motion, which is reciprocating, rotational or both. A clearing stem including a sheath that has a lumen, wherein aspiration is conducted through the sheath lumen. A wire is located in the sheath lumen and receives repetitive motion from the controller. The sheath terminates in a sheath end having at least one sheath opening. The wire terminates in a wire tip, which may be flat, helical, or tubular. The wire tip is positioned within the sheath end, in proximity to the sheath opening(s), and movement of the wire tip and/or sheath end relative to each other creates shearing forces that break up an adjacent occlusion.

Abstract: A transdermal delivery system including a first passive portion containing a substance for delivery in a reservoir and a second active portion that includes an ultrasonic source. The ultrasonic source includes piezoelectric element(s) that receive electrical stimulation and move radially. A support member fixed to one side of the piezoelectric element(s) restricts movement at that side, so the opposite side expands and contracts. A fulcrum attached to the support member opposite of the piezoelectric element(s) provides an anchor point about which the piezoelectric element(s) bends and flexes upon electrical stimulation. This provides a low ultrasound frequency with a smaller sized transducer than previously known. The active portion is applied to provide electrical stimulation for a certain length of time and removed, whereas the passive portion may remain for a longer duration. A feedback loop also monitors and adjusts the electrical stimulation to maintain a uniform or constant resonance frequency.

Abstract: A medical device for reducing the force necessary to penetrate living being tissue using a variety of reciprocating motion actuators. The reciprocating actuator drives a penetrating member, such as a needle, through the tissue at a reduced force while the device detects the passage of the penetrating member through the tissue. Upon passage of the penetrating member through the tissue, a feedback system monitors electromechanical properties of a control signal of the device and automatically modifies control based thereon, e.g., electrical power to the reciprocating actuator is automatically terminated.

Abstract: A medical device for reducing the force necessary to penetrate living being tissue using a variety of reciprocating motion actuators. The reciprocating actuator drives a penetrating member, such as a needle, through the tissue at a reduced force while the device detects the passage of the penetrating member through the tissue. Upon passage of the penetrating member through the tissue, a feedback system monitors electromechanical properties of a control signal of the device and automatically modifies control based thereon, e.g., electrical power to the reciprocating actuator is automatically terminated.

Abstract: A device for differentiating tissue is provided that has a first laser transmission source that outputs a first laser beam in which output from the first laser transmission source is transferred into tissue. A second laser transmission source is provided that outputs a second laser beam that has a wavelength that is different than the first laser beam. Output from the first and second laser transmission sources is transferred into the tissue. A needle system is present for insertion into the tissue along with an acoustic receiver that receives acoustic waves that are created upon the transfer of the output of the first and second laser transmission sources into the tissue. An associated method is also provided.

Abstract: A device for penetrating tissue is provided that has a driving actuator with a body and motor shaft that is reciprocated. A coupler is attached to the motor shaft, and a key engages the driving actuator and coupler and limits rotational motion of the motor shaft and permits linear motion of the motor shaft. A penetrating member is carried by the coupler, and linear motion of the motor shaft is translated to the penetrating member to linearly reciprocate the penetrating member.

Abstract: A device for removing secretions from an artificial tube is provided. The device may include a clearing catheter and a driving mechanism that may apply repetitive motion to the clearing catheter. In another version of the device, the clearing catheter may dispense irrigation fluid and aspirate the irrigation fluid. The clearing catheter may have an irrigation and an aspiration lumen that may both reciprocate with the clearing catheter. In another version a compliant member into which irrigation fluid is located may be present.

Abstract: A medical device for reducing the force necessary to penetrate living being tissue using a variety of reciprocating motion actuators. The reciprocating actuator drives a penetrating member, such as a needle, through the tissue at a reduced force while the device detects the passage of the penetrating member through the tissue. Upon passage of the penetrating member through the tissue, a feedback system monitors electromechanical properties of a control signal of the device and automatically modifies control based thereon, e.g., electrical power to the reciprocating actuator is automatically terminated.