Abstract: Concepts disclosed relate to multi-frame prosthetic valves including leaflet and anchor frame subcomponents, where the leaflet frame subcomponent does not directly couple with patient anatomy and is separated from the anchor frame subcomponent by a gap/space. An optional connecting sheath may be provided to interconnect the subcomponents and assist with prosthetic valve delivery and deployment. One or more bridging members, or annular groove covers, are provided to bridge and cover gap or space between the anchor frame subcomponent and leaflet frame subcomponent, such as at the inflow and/or outflow ends of the subcomponents. Such bridging/cover features may provide smoother flow profiles, reduce incidence of complications, facilitate perfusion during delivery, assist with device nesting during delivery, assist with relative subcomponent positioning following delivery, or provide any of a variety of additional or alternative functions and advantages.

Abstract: A system can include a prosthetic heart valve having a commissure post configured to receive a first portion of a fiber and a suture support configured to engage with the prosthetic heart valve. The suture support can include a first portion to interface with an inflow side of the prosthetic heart valve and a fiber holding portion to receive a second portion of the fiber. A second portion of the suture support can be coupled to the first portion of the suture guard and be movable inwardly toward the first portion of the suture guard to transform the fiber from a non-tensioned state to a tensioned state. The fiber in the tensioned state can cause the commissure post to bend inward toward a longitudinal axis of the prosthetic heart valve.

Abstract: A prosthetic valve includes an annular anchor frame, a leaflet frame configured to nest at least partially within the anchor frame in a nested configuration, one or more leaflets coupled to the leaflet frame, and a bridging member coupled between the leaflet frame and the anchor frame in a manner as to bridge an annular gap defined between the anchor frame and the leaflet frame in the nested configuration, the bridging member being resiliently extendible and retractable in length between an extended configuration and a retracted configuration to permit axial translation of the leaflet frame relative to the anchor frame.

Abstract: A prosthetic implant transitionable between a delivery configuration and a deployed configuration in-situ, the prosthetic implant includes a first frame subcomponent and a second frame subcomponent. The first frame subcomponent and the second frame subcomponent each include a proximal end and a distal end. The second frame subcomponent is coupled to the first frame subcomponent. When situated in the delivery configuration, the first frame subcomponent and the second frame subcomponent are longitudinally offset from one another. When transitioned to the deployed configuration in-situ, the first frame subcomponent is nested within an interior region defined by the second frame subcomponent. The prosthetic implant is configured to capture one or more of the native leaflets of a native valve when the first frame subcomponent and the second frame subcomponent are nested in-situ.

Abstract: Carbon dioxide sorbent article assemblies and methods of manufacturing the same include: separable sheets of sorbent article disposed adjacent to each other to define a gap between adjacent separable sheets, the gap being maintained uniformly between opposing surfaces of adjacent separable sheets to define a passage extending between adjacent separable sheets from an inlet of the separable sheets to an outlet of the separable sheets; and a support framework supporting the separable sheets to maintain the gap, the support framework having a gap-maintaining component extending from the support framework along at least one separable sheet to maintain an initial position of the separable sheet.

Abstract: A prosthetic valve includes an outer frame defining an outer frame lumen, the outer frame including an inflow flange that flares radially outward, a medial portion having a straight wall frame segment, and an outflow end portion that tapers radially inward. The prosthetic valve can further include a leaflet support structure, one or more leaflets secured to the leaflet support structure, and a retention structure configured to hold the leaflet support structure in a fixed position relative to the outer frame when the leaflet structure is disposed at least partially within the outer frame lumen in a deployed configuration of the prosthetic valve.

Abstract: An implantable device is disclosed. The device includes a leaflet frame subcomponent and an anchor frame subcomponent that are configured to be delivered in a series configuration and subsequently nested or telescoped in-situ.

Abstract: A covering for a prosthetic valve comprises a first portion configured to couple to an outflow side of a prosthetic valve and a second portion configured to couple to an inflow side of the prosthetic valve. The first portion is annular in shape and has a first edge alternating between one or more first tips and one or more first valleys. The second portion is also annular in shape and has a second edge alternating between one or more second tips and one or more second valleys. The one or more second tips are configured to couple to the one or more first tips to at least partially cover posts of the prosthetic valve. The one or more second tips have a tapered form.

Abstract: An implantable device is disclosed. The device includes a two or three-piece frame assembly that is configured to be delivered in a series configuration and subsequently nested or telescoped in-situ.

Abstract: Described embodiments are directed toward centrally-opening leaflet prosthetic valve devices having a leaflet frame and a mechanically coupled leaflet. The described leaflet frames have projections that are configured to couple with a leaflet attachment region of a leaflet. Some embodiments include a leaflet retention feature that engages the leaflet frame projections and operates to secure the leaflet to the leaflet frame. Methods of making and using such prosthetic valve devices are also described.

Abstract: A direct air capture (DAC) device includes a plurality of DAC cartridges forming a stacked configuration. Each of the DAC cartridges includes a frame structure having a plurality of perforations facilitating fluid passage therethrough, a plurality of sorbent articles disposed therein and supported by the frame structure, and a plurality of conduits having a plurality of perforations facilitating fluid passage therethrough.

Abstract: A direct air capture (DAC) device includes configurations that allow stacking of DAC cartridges to maintain a stacked configuration within a DAC reactor. The DAC cartridges may have a plurality of sorbent articles disposed within the cartridges and the cartridges may be insertable into a frame or supported by the frame.

Abstract: A direct air capture (DAC) device includes a shelving unit to support at least one sorbent article therein and having an upstream location and a downstream location for transporting steam. The shelving unit includes a set of support members forming a plurality of housing portions in which the sorbent article is housed. The support members include first support members extending parallel to each other in a first orientation, and second support members extending parallel to each other in a second orientation different from the first orientation.

Abstract: Described embodiments are directed toward centrally-opening leaflet prosthetic valve devices having a leaflet frame and a mechanically coupled leaflet. The described leaflet frames have projections that are configured to couple with a leaflet attachment region of a leaflet. Some embodiments include a leaflet retention feature that engages the leaflet frame projections and operates to secure the leaflet to the leaflet frame. Methods of making and using such prosthetic valve devices are also described.

Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include a prosthetic valve. The prosthetic valve may include a jacket configured to cover at least one of gaps, spaces, or interfaces in a frame or between one or more leaflets attached to the frame.

Abstract: A system can include a prosthetic heart valve having a commissure post configured to receive a first portion of a fiber and a suture support configured to engage with the prosthetic heart valve. The suture support can include a first portion to interface with an inflow side of the prosthetic heart valve and a fiber holding portion to receive a second portion of the fiber. A second portion of the suture support can be coupled to the first portion of the suture guard and be movable inwardly toward the first portion of the suture guard to transform the fiber from a non-tensioned state to a tensioned state. The fiber in the tensioned state can cause the commissure post to bend inward toward a longitudinal axis of the prosthetic heart valve.

Abstract: A system includes a heart valve and a device that functions to minimize a possibility for suture becoming entangled with a commissure post of the heart valve during an implantation procedure. In some examples, the device is a suture guard that includes one or more features that deflect suture to help minimize entanglement of the same with the commissure posts of the heart valve. In some examples, the features operate to deflect the commissure posts radially inwardly, while in other examples, the features overlay the commissure posts without deflecting that same.

Abstract: Prosthetic valves and associated methods and systems are disclosed, including a prosthetic valve with a support structure and a leaflet construct coupled to the support structure, and a tissue cutting element coupled to a portion of the prosthetic valve.

Abstract: A transcatheter system is disclosed, which includes a delivery sheath, a delivery system coupled to an implant and received by the delivery sheath, and a manipulation system. The manipulation system includes a manipulation device. The manipulation device includes an elongate portion that is extendable and retractable within the delivery sheath and an engaging portion extending from the elongate portion. The engaging portion is coupled to an internal bodily structure to be manipulated, and the manipulation system is received by the delivery sheath such that the engaging portion is extendable from the delivery sheath independently from the implant.

Abstract: Systems and methods for cutting tissue using a transcatheter approach are disclosed. In some examples, the systems and methods are implemented as part of a delivery system that includes an implant with a support structure and a cutting element coupled to the support structure, such that the cutting element configured to cut tissue.