Patents by Inventor Ryan SHULTZABERGER

Ryan SHULTZABERGER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Strand displacing amplification enzymes
    Patent number: 12668834
    Abstract: Disclosed herein, inter alia, are novel strand-displacing polymerases and methods of use thereof.
    Type: Grant
    Filed: December 21, 2022
    Date of Patent: June 30, 2026
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Souad Naji, Eli N. Glezer, Bruna Krebs Kutche, Ali Nikoomanzar, Alexander Sevy, Caleb Newman, Ryan Shultzaberger, Abrehet Abdu, Youngjin Cho, Janell J. Kosmatka
  • STRAND DISPLACING AMPLIFICATION ENZYMES
    Publication number: 20260176677
    Abstract: Disclosed herein, inter alia, are novel strand-displacing polymerases and methods of use thereof.
    Type: Application
    Filed: March 5, 2026
    Publication date: June 25, 2026
    Inventors: Souad NAJI, Eli N. GLEZER, Bruna Krebs KUTCHE, Ali NIKOOMANZAR, Alexander SEVY, Caleb NEWMAN, Ryan SHULTZABERGER, Abrehet ABDU, Youngjin CHO, Janell J. KOSMATKA
  • METHODS AND PROBES FOR DETECTING POLYNUCLEOTIDE SEQUENCES IN CELLS AND TISSUES
    Publication number: 20260125752
    Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for detecting polynucleotides from and within cells and tissues.
    Type: Application
    Filed: November 4, 2025
    Publication date: May 7, 2026
    Inventors: Tung Thanh LE, Ryan SHULTZABERGER, Daan WITTERS
  • DETECTING POLYNUCLEOTIDES WITH BARCODED OLIGONUCLEOTIDE PROBES
    Publication number: 20250027143
    Abstract: Provided herein are methods of detecting polynucleotides with a set of barcoded oligonucleotide probes.
    Type: Application
    Filed: September 19, 2024
    Publication date: January 23, 2025
    Inventors: Eli N. Glezer, Martin Maria Fabani, Ryan Shultzaberger, Bharat Sridhar, Gudrun Stengel, Christopher Jen-Yue Wei
  • NUCLEIC ACID CIRCULARIZATION AND AMPLIFICATION ON A SURFACE
    Publication number: 20240392369
    Abstract: Disclosed herein, inter alia, are compositions and methods for amplification and sequencing of nucleic acids.
    Type: Application
    Filed: July 18, 2024
    Publication date: November 28, 2024
    Inventors: Daan Witters, Eli N. Glezer, Andrew King, Sabrina Shore, Ryan Shultzaberger
  • Polynucleotide barcodes for long read sequencing
    Patent number: 12139754
    Abstract: Provided herein are methods of making, amplifying, and sequencing tagged nucleic acid complements, compositions including interposing oligonucleotide barcodes, and kits useful in obtaining long-range sequence data.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: November 12, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Martin Maria Fabani, Ryan Shultzaberger, Bharat Sridhar, Gudrun Stengel, Christopher Jen-Yue Wei
  • Linked paired strand sequencing
    Patent number: 12123055
    Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.
    Type: Grant
    Filed: April 22, 2022
    Date of Patent: October 22, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Martin Maria Fabani, Timothy Looney, Sabrina Shore, Ryan Shultzaberger, Daan Witters
  • Nucleic acid circularization and amplification on a surface
    Patent number: 12071665
    Abstract: Disclosed herein, inter alia, are compositions and methods for amplification of nucleic acid templates, including hybridizing a linear polynucleotide to an immobilized primer on a surface, circularizing the linear polynucleotide to form a circular polynucleotide, and extending the primer with a polymerase.
    Type: Grant
    Filed: March 1, 2023
    Date of Patent: August 27, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Daan Witters, Eli N. Glezer, Andrew King, Sabrina Shore, Ryan Shultzaberger
  • AMPLIFICATION OLIGONUCLEOTIDES
    Publication number: 20240093283
    Abstract: Disclosed herein, inter alia, are polynucleotides, supports, kits, and methods of use thereof for amplifying, immobilizing, and sequencing polynucleotides.
    Type: Application
    Filed: November 13, 2023
    Publication date: March 21, 2024
    Inventors: Ryan Shultzaberger, Allen Lipson, Daan Witters
  • Amplification oligonucleotides
    Patent number: 11932905
    Abstract: Disclosed herein, inter alia, are polynucleotides, supports, kits, and methods of use thereof for amplifying, immobilizing, and sequencing polynucleotides.
    Type: Grant
    Filed: March 17, 2023
    Date of Patent: March 19, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ryan Shultzaberger, Allen Lipson, Daan Witters
  • Amplification oligonucleotides
    Patent number: 11859244
    Abstract: Disclosed herein, inter alia, are polynucleotides, supports, kits, and methods of use thereof for amplifying, immobilizing, and sequencing polynucleotides.
    Type: Grant
    Filed: March 17, 2023
    Date of Patent: January 2, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ryan Shultzaberger, Allen Lipson, Daan Witters
  • NUCLEIC ACID CIRCULARIZATION AND AMPLIFICATION ON A SURFACE
    Publication number: 20230357843
    Abstract: Disclosed herein, inter alia, are compositions and methods for efficient amplification and sequencing of nucleic acid templates.
    Type: Application
    Filed: March 1, 2023
    Publication date: November 9, 2023
    Inventors: Daan WITTERS, Eli N. GLEZER, Andrew KING, Sabrina SHORE, Ryan SHULTZABERGER
  • Amplification oligonucleotides
    Patent number: 11802307
    Abstract: Disclosed herein, inter alia, are polynucleotides, supports, kits, and methods of use thereof for amplifying, immobilizing, and sequencing polynucleotides.
    Type: Grant
    Filed: March 17, 2023
    Date of Patent: October 31, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ryan Shultzaberger, Allen Lipson, Daan Witters
  • AMPLIFICATION OLIGONUCLEOTIDES
    Publication number: 20230287493
    Abstract: Disclosed herein, inter alia, are polynucleotides, supports, kits, and methods of use thereof for amplifying, immobilizing, and sequencing polynucleotides.
    Type: Application
    Filed: March 17, 2023
    Publication date: September 14, 2023
    Inventors: Ryan SHULTZABERGER, Allen LIPSON, Daan WITTERS
  • AMPLIFICATION OLIGONUCLEOTIDES
    Publication number: 20230287492
    Abstract: Disclosed herein, inter alia, are polynucleotides, supports, kits, and methods of use thereof for amplifying, immobilizing, and sequencing polynucleotides.
    Type: Application
    Filed: March 17, 2023
    Publication date: September 14, 2023
    Inventors: Ryan SHULTZABERGER, Allen LIPSON, Daan WITTERS
  • STRAND DISPLACING AMPLIFICATION ENZYMES
    Publication number: 20230257803
    Abstract: Disclosed herein, inter alia, are novel strand-displacing polymerases and methods of use thereof.
    Type: Application
    Filed: December 21, 2022
    Publication date: August 17, 2023
    Inventors: Souad NAJI, Eli N. GLEZER, Bruna Krebs KUTCHE, Ali NIKOOMANZAR, Alexander SEVY, Caleb NEWMAN, Ryan SHULTZABERGER, Abrehet ABDU, Youngjin CHO, Janell J. KOSMATKA
  • AMPLIFICATION OLIGONUCLEOTIDES
    Publication number: 20230212664
    Abstract: Disclosed herein, inter alia, are polynucleotides, supports, kits, and methods of use thereof for amplifying, immobilizing, and sequencing polynucleotides.
    Type: Application
    Filed: March 17, 2023
    Publication date: July 6, 2023
    Inventors: Ryan SHULTZABERGER, Allen LIPSON, Daan WITTERS
  • STRAND DISPLACING SEQUENCING ENZYMES
    Publication number: 20230203578
    Abstract: Disclosed herein, inter alia, are methods, enzymes, and compositions useful for nucleic acid sequencing.
    Type: Application
    Filed: December 21, 2022
    Publication date: June 29, 2023
    Inventors: Souad NAJI, Eli N. GLEZER, Bruna Krebs KUTCHE, Ali NIKOOMANZAR, Alexander SEVY, Caleb NEWMAN, Ryan SHULTZABERGER, Abrehet ABDU, Youngjin CHO, Janell J. KOSMATKA
  • LINKED PAIRED STRAND SEQUENCING
    Publication number: 20230203576
    Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.
    Type: Application
    Filed: November 17, 2022
    Publication date: June 29, 2023
    Inventors: Eli N. GLEZER, Martin Maria FABANI, Timothy LOONEY, Sabrina SHORE, Ryan SHULTZABERGER, Daan WITTERS
  • LINKED PAIRED STRAND SEQUENCING
    Publication number: 20220282324
    Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.
    Type: Application
    Filed: April 22, 2022
    Publication date: September 8, 2022
    Inventors: Eli N. GLEZER, Martin Maria FABANI, Timothy LOONEY, Sabrina SHORE, Ryan SHULTZABERGER, Daan WITTERS