Abstract: Provided herein are aminoglycoside compounds, such as compounds of Formula (I) and Formula (III), and pharmaceutically acceptable salts thereof, useful as therapeutic and/or prophylactic agents. The compounds may be useful in treating a bacterial infection in a subject, for example a Gram-negative bacterial infection. Also provided herein are methods for preparation of such compounds.

Abstract: In some implementations, a method of sketch-based placement of computer-generated graphical objects includes: obtaining an input directed to a content creation region within a user interface, wherein the input corresponds to a sketch of a candidate object, and wherein the user interface includes the content creation region and a presentation region for computer-generated content; and in response to obtaining the input directed to the content creation region: presenting the sketch within the content creation region; obtaining a three-dimensional (3D) model using the input that corresponds to the sketch of the candidate object; generating a computer-generated graphical object using the obtained 3D model; and causing presentation of the computer-generated graphical object together with imagery obtained using the one or more cameras of the device within the presentation region while maintaining presentation of the sketch within the content creation region.

Abstract: In some implementations, a method of sketch-based placement of computer-generated graphical objects includes: obtaining an input directed to a content creation region within a user interface, wherein the input corresponds to a sketch of a candidate object, and wherein the user interface includes the content creation region and a presentation region for computer-generated content; and in response to obtaining the input directed to the content creation region: presenting the sketch within the content creation region; obtaining a three-dimensional (3D) model using the input that corresponds to the sketch of the candidate object; generating a computer-generated graphical object using the obtained 3D model; and causing presentation of the computer-generated graphical object together with imagery obtained using the one or more cameras of the device within the presentation region while maintaining presentation of the sketch within the content creation region.

Abstract: The method performed at an electronic device including one or more processors, a non-transitory memory, and a depth sensor includes: obtaining a task associated with a physical object within a physical environment; obtaining a task associated with a physical object within a physical environment; obtaining depth information, via the depth sensor, associated with the physical environment; determining one or more measurements for the physical object based at least in part on the depth information; generating a graphical overlay for the task based at least in part on the task associated with the physical object and the one or more measurements for the physical object; and causing presentation of the graphical overlay relative to a representation of the physical object, wherein the representation is obtained using sensor readings of the physical object.

Abstract: A thermogenic emergency airway management device configured to prevent or treat hypothermia in a patient. The device may be configured to receive inlet air and modify one or more properties of the inlet air to output air at a temperature and/or humidity associated with the prevention and/or treatment of hypothermia. In an embodiment, the device may receive input via a user interface to determine a temperature and/or humidity associated with the air to be output to the patient. In an embodiment, the input may additionally include an amount of air to be output to the patient. In such an embodiment, the device may be configured to cause the amount of air to be output to the patient to prevent and/or treat hypothermia.

Abstract: An apparatus and methods are provided for a front plate having a diverging central bore for firearm sound suppressors that improves noise and flash characteristics during firing a weapon. The central bore is disposed between a back surface and a front surface of the front plate. An untapered portion of the central bore extends from the back surface to a diverging portion that opens toward the front surface. The diverging portion includes a curvature profile configured to allow for more controlled expansion of high-pressure propellant gases exiting of the suppressor through the central bore. The curvature profile provides an included angle of the central bore that decreases secondary flash events accompanying the expulsion of propellant gases accompanying a fired bullet exiting the suppressor through the central bore. The curvature profile exhibits a cross-sectional area of the central bore that is proportional to a distance along the diverging portion.

Abstract: Methods for treatment for patients suffering from disease or condition are contemplated as including an administration of an intravenous infusion of a pharmaceutically effective amount of psilocybin or psilocin. The intravenous infusion of psilocybin or psilocin may include an additional compound such as a benzodiazepine, preferably lorazepam, administered via a continuous intra-venous infusion. Such methods may be seen to better alleviate the symptoms of psychological conditions, neurological injuries, pain, or inflammatory condition, and may result in reduced need for other medications.

Abstract: In some implementations, a method of sketch-based placement of computer-generated graphical objects includes: obtaining an input directed to a content creation region within a user interface, wherein the input corresponds to a sketch of a candidate object, and wherein the user interface includes the content creation region and a presentation region for computer-generated content; and in response to obtaining the input directed to the content creation region: presenting the sketch within the content creation region; obtaining a three-dimensional (3D) model using the input that corresponds to the sketch of the candidate object; generating a computer-generated graphical object using the obtained 3D model; and causing presentation of the computer-generated graphical object together with imagery obtained using the one or more cameras of the device within the presentation region while maintaining presentation of the sketch within the content creation region.

Abstract: An apparatus and methods are provided for a front plate having a diverging central bore for firearm sound suppressors that improves noise and flash characteristics during firing a weapon. The central bore is disposed between a back surface and a front surface of the front plate. An untapered portion of the central bore extends from the back surface to a diverging portion that opens toward the front surface. The diverging portion includes a curvature profile configured to allow for more controlled expansion of high-pressure propellant gases exiting of the suppressor through the central bore. The curvature profile provides an included angle of the central bore that decreases secondary flash events accompanying the expulsion of propellant gases accompanying a fired bullet exiting the suppressor through the central bore. The curvature profile exhibits a cross-sectional area of the central bore that is proportional to a distance along the diverging portion.

Abstract: An apparatus and methods are provided for a suppressor to be coupled with a muzzle end of a barrel of a firearm to reduce muzzle blast and muzzle flash. The suppressor comprises a housing having a proximal end and a distal end. A front portion within the housing comprises a series of cylindrical gas expansion chambers for attenuating the temperature and energy of propellant gases accompanying a projectile fired from the firearm. An annular gas expansion chamber surrounds the cylindrical gas expansion chambers and directs a portion of the propellant gases from a rear portion of the suppressor to peripheral vents disposed at the distal end. Lateral chambers within the rear portion deflect and rebound a portion of the propellant gases before passing them into the annular gas expansion chamber. Ledges within the annular gas expansion chamber direct the propellant gases distally through suppressor toward the peripheral vents.

Abstract: The method performed at an electronic device including one or more processors, a non-transitory memory, and a depth sensor includes: obtaining a task associated with a physical object within a physical environment; obtaining a task associated with a physical object within a physical environment; obtaining depth information, via the depth sensor, associated with the physical environment; determining one or more measurements for the physical object based at least in part on the depth information; generating a graphical overlay for the task based at least in part on the task associated with the physical object and the one or more measurements for the physical object; and causing presentation of the graphical overlay relative to a representation of the physical object, wherein the representation is obtained using sensor readings of the physical object.

Abstract: In some implementations, a method of sketch-based placement of computer-generated graphical objects is performed at a device including one or more cameras and non-transitory memory coupled to one or more processors. The method includes obtaining an input directed to a content creation interface (e.g., a sketchpad), wherein the input corresponds to a sketch of a candidate object, and wherein the content creation interface facilitates creation of computer-generated graphical objects presentable using the device. The method also includes: obtaining a three-dimensional (3D) model using the input that corresponds to the sketch of the candidate object; generating a computer-generated graphical object using the obtained 3D model; and causing presentation of the computer-generated graphical object together with imagery obtained using the one or more cameras of the device.

Abstract: A personal protection equipment (PPE) gown formed by one piece woven (OPW) techniques. The gown features an outer coating on the fabric to provide required liquid penetration resistance.

Abstract: The method performed at an electronic device including one or more processors, a non-transitory memory, and a depth sensor includes: obtaining a task associated with a physical object within a physical environment; obtaining depth information, via the depth sensor, associated with the physical environment; determining one or more measurements for the physical object based at least in part on the depth information; obtaining a graphical overlay based at least in part on the task and the one or more measurements for the physical object; and causing presentation of the graphical overlay adjacent to a representation of the physical object, wherein the representation is obtained using sensor readings of the physical object.

Abstract: An apparatus and methods are provided for a suppressor to be coupled with a muzzle end of a barrel of a firearm to reduce muzzle blast and muzzle flash. The suppressor comprises a housing having a proximal end and a distal end. A front portion within the housing comprises a series of cylindrical gas expansion chambers for attenuating the temperature and energy of propellant gases accompanying a projectile fired from the firearm. An annular gas expansion chamber surrounds the cylindrical gas expansion chambers and directs a portion of the propellant gases from a rear portion of the suppressor to peripheral vents disposed at the distal end. Lateral chambers within the rear portion deflect and rebound a portion of the propellant gases before passing them into the annular gas expansion chamber. Ledges within the annular gas expansion chamber direct the propellant gases distally through suppressor toward the peripheral vents.

Abstract: A marina solar energy system and method is provided. The system includes one or more base assemblies designed to support corresponding solar panel assemblies. For example, the system may include dock box lids with recesses adapted to receive and secure one or more solar panels, and an energy distribution system to receive and distribute the energy produced by the solar panel assemblies (e.g., to other areas of the marina, to a local power grid, etc.). The system also may include rechargeable power sources, such as rechargeable battery packs, that may store the energy produced by the solar panels. The system also may include electrical outlets for use by occupants of the marina.

Abstract: Cyclone Rolling Circle Amplification (CRCA) based next-generation sequencing (NGS) using a multiple primer rolling circle amplification (RCA) reaction is generated using two or more tandem primers from the same strand on different locations of library adaptor regions of double stranded enriched targeted polymerase chain reaction (PCR) library products. This process allows multiple initiation and syntheses of the RCA reaction by an enzyme on the same circular template molecule, which is beneficial since the two or more primers complement each other in generating uniform amplification of the target circle population. Also, a method for keeping DNA nanoballs (also known as rolonies) compact, or more compact, and for pre-priming rolonies before sequencing to eliminate the hybridization of a seqeuncing primer after seeding the rolonies, and a Rolonies rolling circle amplification (RCA) based next-generation sequencing (NGS) using a dual Rolonies primer approach named REPLI-Rolony.

Abstract: In some implementations, a method of sketch-based placement of computer-generated graphical objects is performed at a device including one or more cameras and non-transitory memory coupled to one or more processors. The method includes obtaining an input directed to a content creation interface (e.g., a sketchpad), wherein the input corresponds to a sketch of a candidate object, and wherein the content creation interface facilitates creation of computer-generated graphical objects presentable using the device. The method also includes: obtaining a three-dimensional (3D) model using the input that corresponds to the sketch of the candidate object; generating a computer-generated graphical object using the obtained 3D model; and causing presentation of the computer-generated graphical object together with imagery obtained using the one or more cameras of the device.

Abstract: A method inspects weld quality in-situ. The method obtains a plurality of sequenced images of an in-progress welding process and generates a multi-dimensional data input based on the plurality of sequenced images and/or one or more weld process control parameters. The parameters may include: (i) shield gas flow rate, temperature, and pressure; (ii) voltage, amperage, wire feed rate and temperature (if applicable); (iii) part preheat/inter-pass temperature; and (iv) part and weld torch relative velocity). The method generates defect probability and analytics information by applying one or more computer vision techniques on the multi-dimensional data input. The analytics information includes predictive insights on quality features of the in-progress welding process. The method then generates a 3-D visualization of one or more as-welded regions, based on the analytics information, and the plurality of sequenced images.

Abstract: Disclosed is an oil catch can device employing a porous polymer matrix which filters and collects oil and other combustion byproducts typically found in “blow-by” gasses of an internal combustion engine. Employing a porous polymer matrix is a more effective means of filtering and collecting components of blow-by gasses due to the physical and chemical properties of the matrix. Various polymers can be used to produce the porous polymer matrix. By controlling the polymer type and particle size distribution of the particles that are sintered to create the matrix, filtration and adsorption can be maximized while maintaining a sufficient flow rate of gasses through the device.