Patents by Inventor Ryan Swanson

Ryan Swanson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CD80 VARIANT IMMUNOMODULATORY PROTEINS AND USES THEREOF
    Publication number: 20240002466
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Application
    Filed: March 10, 2023
    Publication date: January 4, 2024
    Applicant: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker, Mark F. Maurer, Dan Ardourel, Daniel William Demonte, Joseph L. Kuijper
  • CD112 variant immunomodulatory proteins and uses thereof
    Patent number: 11834490
    Abstract: Provided herein are immunomodulatory proteins comprising variant CD112 and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: December 5, 2023
    Assignee: ALPINE IMMUNE SCIENCES, INC.
    Inventors: Ryan Swanson, Michael Kornacker, Daniel William Demonte, Mark F. Maurer, Dan Ardourel, Joseph L. Kuijper
  • CD155 VARIANT IMMUNOMODULATORY PROTEINS AND USES THEREOF
    Publication number: 20230381229
    Abstract: Provided herein are immunomodulatory proteins comprising variant CD155 and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Application
    Filed: October 14, 2022
    Publication date: November 30, 2023
    Applicant: ALPINE IMMUNE SCIENCES, INC.
    Inventors: Ryan SWANSON, Michael KORNACKER, Daniel William DEMONTE, Mark F. MAURER
  • CTLA-4 variant immunomodulatory proteins and uses thereof
    Patent number: 11753458
    Abstract: Provided herein are variant CTLA-4 polypeptides and immunomodulatory proteins and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of disease applications, including for treatment of autoimmune or inflammatory conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: September 12, 2023
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Lawrence Evans, Joseph L. Kuijper, Ryan Swanson
  • PD-L2 variant immunomodulatory proteins and uses thereof
    Patent number: 11732022
    Abstract: Provided herein are immunomodulatory proteins comprising variant PD-L2 and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: August 22, 2023
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker, Mark F. Maurer, Dan Ardourel, Daniel William Demonte, Joseph L. Kuijper
  • CTLA-4 VARIANT IMMUNOMODULATORY PROTEINS AND USES THEREOF
    Publication number: 20230250152
    Abstract: Provided herein are variant CTLA-4 polypeptides and immunomodulatory proteins and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of disease applications, including for treatment of autoimmune or inflammatory conditions. Compositions and methods for making and using such proteins are provided.
    Type: Application
    Filed: January 30, 2023
    Publication date: August 10, 2023
    Applicant: Alpine Immune Sciences, Inc.
    Inventors: Lawrence EVANS, Joseph L. Kuijper, Ryan Swanson
  • APRIL AND BAFF INHIBITORY IMMUNOMODULATORY PROTEINS WITH AND WITHOUT A T CELL INHIBITORY PROTEIN AND METHODS OF USE THEREOF
    Publication number: 20230241168
    Abstract: Provided herein are immunomodulatory proteins that exhibit neutralizing activity of BAFF and APRIL (or BAFF/APRIL heterotrimers) alone, or also coupled with inhibition of T cell costimulation. The immunomodulatory proteins provided herein include variant domains of B cell maturation antigen (BCMA) alone, or multi-domain immunomodulatory protein that inhibit B cell responses and also can inhibit T cell costimulation. Also provided are nucleic acids molecules encoding the immunomodulatory proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological diseases or conditions. Also provided are compositions and methods for making and using such proteins.
    Type: Application
    Filed: May 7, 2021
    Publication date: August 3, 2023
    Applicant: Alpine Immune Sciences, Inc.
    Inventors: Stacey DILLON, Mark RIXON, Lawrence EVANS, Daniel William DEMONTE, Joseph L. KUIJPER, Stanford L. PENG, Ryan SWANSON
  • VARIANT ICOS LIGAND IMMUNOMODULATORY PROTEINS AND RELATED COMPOSITIONS AND METHODS
    Publication number: 20230235012
    Abstract: Provided herein are immunomodulatory proteins comprising ICOSL variants and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Application
    Filed: February 21, 2023
    Publication date: July 27, 2023
    Applicant: Alpine Immune Sciences, Inc.
    Inventors: Lawrence Evans, Michael Kornacker, Ryan Swanson
  • PD-L1 VARIANT IMMUNOMODULATORY PROTEINS AND USES THEREOF
    Publication number: 20230220039
    Abstract: Provided herein are immunomodulatory proteins comprising variant PD-L1 and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Application
    Filed: March 13, 2018
    Publication date: July 13, 2023
    Applicant: Alpine Immune Sciences, Inc.
    Inventors: Ryan SWANSON, Michael KORNACKER, Mark F. MAURER, Dan ARDOUREL, Daniel William DEMONTE, Joseph L. KUJIPER
  • CD80 VARIANT IMMUNOMODULATORY PROTEINS AND USES THEREOF
    Publication number: 20230136723
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Application
    Filed: October 7, 2022
    Publication date: May 4, 2023
    Applicant: Alpine Immune Sciences, Inc.
    Inventors: Ryan SWANSON, Michael KORNACKER
  • CD80 variant immunomodulatory proteins and uses thereof
    Patent number: 11639375
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: May 2, 2023
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker, Mark F. Maurer, Joseph L. Kuijper
  • MULTI-DOMAIN IMMUNOMODULATORY PROTEINS AND METHODS OF USE THEREOF
    Publication number: 20230101432
    Abstract: Provided herein are multi-domain immunomodulatory proteins, nucleic acids encoding such immunomodulatory proteins, cells engineered to express the immunomodulatory proteins and infectious agents containing nucleic acid encoding the immunomodulatory proteins. The immunomodulatory proteins bind both an inhibitory receptor and a receptor involved in activation signaling cascades in an immune cell, such as a T cell. The immunomodulatory proteins, engineered cells and infectious agents provide therapeutic utility for a variety of immunological diseases or conditions. Compositions and methods for making and using such proteins are provided.
    Type: Application
    Filed: January 3, 2019
    Publication date: March 30, 2023
    Applicant: Alpine Immune Sciences, Inc.
    Inventor: Ryan SWANSON
  • Variant ICOS ligand immunomodulatory proteins and related compositions and methods
    Patent number: 11613566
    Abstract: Provided herein are immunomodulatory proteins comprising ICOSL variants and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: December 22, 2021
    Date of Patent: March 28, 2023
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Lawrence Evans, Michael Kornacker, Ryan Swanson
  • CD86 VARIANT IMMUNOMODULATORY PROTEINS AND USES THEREOF
    Publication number: 20220372106
    Abstract: Provided herein are variant CD86 polypeptides, immunomodulatory proteins comprising variant CD86 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Application
    Filed: November 27, 2019
    Publication date: November 24, 2022
    Applicant: Alpine Immune Sciences, Inc.
    Inventors: Ryan SWANSON, Dan ARDOUREL, Steven Dennis LEVIN, Joseph L. KUIJPER
  • CD80 variant immunomodulatory proteins and uses thereof
    Patent number: 11498967
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: February 2, 2022
    Date of Patent: November 15, 2022
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker
  • CD80 variant immunomodulatory proteins and uses thereof
    Patent number: 11479609
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: February 2, 2022
    Date of Patent: October 25, 2022
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker
  • CD155 variant immunomodulatory proteins and uses thereof
    Patent number: 11471488
    Abstract: Provided herein are immunomodulatory proteins comprising variant CD155 and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: October 18, 2022
    Assignee: ALPINE IMMUNE SCIENCES, INC.
    Inventors: Ryan Swanson, Michael Kornacker, Daniel William Demonte, Mark F. Maurer
  • IMMUNOMODULATORY PROTEINS WITH TUNABLE AFFINITIES
    Publication number: 20220242930
    Abstract: Provided are immunomodulatory proteins and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Application
    Filed: March 29, 2022
    Publication date: August 4, 2022
    Applicant: Alpine Immune Sciences, Inc.
    Inventors: Ryan SWANSON, Michael KORNACKER
  • METHODS AND USES OF VARIANT ICOS LIGAND (ICOSL) FUSION PROTEINS
    Publication number: 20220218785
    Abstract: Provided herein are immunomodulatory proteins comprising ICOSL variants and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Application
    Filed: April 16, 2020
    Publication date: July 14, 2022
    Applicant: Alpine Immune Sciences, Inc.
    Inventors: Ryan SWANSON, Jing YANG, Stanford PENG, Jan HILLSON
  • CD80 variant immunomodulatory proteins and uses thereof
    Patent number: 11359022
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: June 11, 2021
    Date of Patent: June 14, 2022
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker