Abstract: A security apparatus for securing a portable electronic device to an immovable object includes a locking head having a base and a plurality of pillar structures extending from the base. The plurality of pillar structures is configured to be inserted into an aperture of the portable electronic device. The locking head also has a ball positioned within each of the plurality of pillar structures. The ball is extendable outwardly from a corresponding pillar structure to inhibit the locking head from being removed from the aperture. The locking head further has a linear movable structure positioned within each of the plurality of pillar structures and operable to selectively extend outwardly each ball from the plurality of pillar structures. The security apparatus also includes a security device attached to the locking head and configured to engage the immovable object.

Abstract: In the specification and drawings a cooler-mounted utility table is described and shown with a work surface; a vertical support member; at least one work surface support rail connected to the work surface and pivotally connected to the vertical support member so that the work surface may pivot from a horizontal position for use and a vertical position for storage and transport; and a mounting bracket configured to securely receive the vertical support member and to be attached to the cooler using the existing structure of the cooler.

Abstract: A security apparatus for securing a portable electronic device to an immovable object includes a locking head having a base and a plurality of pillar structures extending from the base. The plurality of pillar structures is configured to be inserted into an aperture of the portable electronic device. The locking head also has a ball positioned within each of the plurality of pillar structures. The ball is extendable outwardly from a corresponding pillar structure to inhibit the locking head from being removed from the aperture. The locking head further has a linear movable structure positioned within each of the plurality of pillar structures and operable to selectively extend outwardly each ball from the plurality of pillar structures. The security apparatus also includes a security device attached to the locking head and configured to engage the immovable object.

Abstract: A security apparatus for securing a portable electronic device to an immovable object includes a locking head having a base and a first linear element extending from the base. The first linear element is configured to be inserted into the aperture of the portable electronic device. The locking head also has a movable engagement element coupled to an end of the first linear element opposite from the base. The movable engagement element is configured to be inserted into the aperture of the portable electronic device with the first linear element. The movable engagement element is movable to a position in which the movable engagement element is perpendicular to the first linear element to secure the locking head to the portable electronic device. The security apparatus also includes a security device attached to the locking head and configured to engage the immovable object.

Abstract: A security apparatus for securing a portable electronic device to an immovable object includes a locking head having a base and a first linear element extending from the base. The first linear element is configured to be inserted into the aperture of the portable electronic device. The locking head also has a movable engagement element coupled to an end of the first linear element opposite from the base. The movable engagement element is configured to be inserted into the aperture of the portable electronic device with the first linear element. The movable engagement element is movable to a position in which the movable engagement element is perpendicular to the first linear element to secure the locking head to the portable electronic device. The security apparatus also includes a security device attached to the locking head and configured to engage the immovable object.

Abstract: A security apparatus for securing a portable electronic device to an immovable object includes a locking head having a base and a plurality of engagement portions extending from the base. The plurality of engagement portions is configured to be inserted into an aperture of the portable electronic device. The locking head also includes a linear portion positioned between the plurality of engagement portions and extending from the base. The linear portion is twistable about its length to move the plurality of engagement portions radially outward. The security apparatus further includes a security device attached to the locking head and configured to engage the immovable object.

Abstract: A security apparatus for securing a portable electronic device to an immovable object includes a locking head having a base and a plurality of engagement portions extending from the base. The plurality of engagement portions is configured to be inserted into an aperture of the portable electronic device. The locking head also includes a linear portion positioned between the plurality of engagement portions and extending from the base. The linear portion is twistable about its length to move the plurality of engagement portions radially outward. The security apparatus further includes a security device attached to the locking head and configured to engage the immovable object.

Abstract: A security apparatus for securing a portable electronic device to an immovable object includes a locking head having a base and a plurality of engagement portions extending from the base. The plurality of engagement portions is configured to be inserted into an aperture of the portable electronic device. The locking head also includes a linear portion positioned between the plurality of engagement portions and extending from the base. The linear portion is twistable about its length to move the plurality of engagement portions radially outward. The security apparatus further includes a security device attached to the locking head and configured to engage the immovable object.

Abstract: A security apparatus for a portable electronic device includes a locking head having a base and an engagement element extending from the base and adapted to be inserted into an aperture of the portable electronic device. The engagement element includes a wedge-shaped engagement portion configured to engage part of the portable electronic device when inserted into the aperture. The locking head also has a stabilizing element extending from the base and slidable along a side of the engagement element into the aperture of the portable electronic device, thereby inhibiting the engagement element from being removed from the aperture. The security apparatus further includes a security device attached to the locking head and configured to engage the immovable object.

Abstract: A security apparatus for a portable electronic device includes a locking head having a base and an engagement element extending from the base and adapted to be inserted into an aperture of the portable electronic device. The engagement element includes a wedge-shaped engagement portion configured to engage part of the portable electronic device when inserted into the aperture. The locking head also has a stabilizing element extending from the base and slidable along a side of the engagement element into the aperture of the portable electronic device, thereby inhibiting the engagement element from being removed from the aperture. The security apparatus further includes a security device attached to the locking head and configured to engage the immovable object.

Abstract: A system for removing snow from a rooftop comprising a plurality of interconnected pipes installed on the rooftop configured to provide a fluidic path to carry heat transfer fluid. The plurality of interconnected pipes forms a framework over the rooftop. A roof cover is attached to the interconnected pipes to cover the rooftop. The heat exchange pump circulates the heat transfer fluid through the interconnected pipes to maintain the temperature of the rooftop cover above the freezing temperature for the snow to melt and slide down from the roof. A solar panel charges a rechargeable battery which is configured to supply power to a heater configured to heat the heat transfer fluid. A controller controls the heater and heat exchange pump to supply the heat transfer fluid to the interconnected pipes to heat the roof cover. The roof cover is a combination of fiber added thermally conductive plastic material and plastic polymer.

Abstract: A security apparatus for securing a portable electronic device to an immovable object includes a locking head having a base and a plurality of engagement portions extending from the base. The plurality of engagement portions is configured to be inserted into an aperture of the portable electronic device. The locking head also includes a linear portion positioned between the plurality of engagement portions and extending from the base. The linear portion is twistable about its length to move the plurality of engagement portions radially outward. The security apparatus further includes a security device attached to the locking head and configured to engage the immovable object.

Abstract: Provided are unimolecular oligonucleotide probes for detecting a target in a sample. The probes use target binding-induced structural changes to detect the presence of the target in the sample. Also provided are methods of using the probes to detect a target in a sample.

Abstract: A security apparatus for securing a portable electronic device to an immovable object includes a head having a base. The head also includes a plurality of engagement elements extending from the base and configured to be inserted into an aperture of the portable electronic device. The plurality of engagement elements is movable relative to the body while inserted into the aperture to engage a portion of the portable electronic device. The head further includes a linear element positioned between the plurality of engagement elements. The linear element is movable relative to the plurality of engagement elements to push the plurality of engagement elements radially outward. The security apparatus also includes a security device attached to the head and configured to engage the immovable object.

Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A3, A4, A5, A6, L, R2, R7, X, Y and Z of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.

Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, L, R2, R7, X, Y and Z of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.

Abstract: The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, each of Ra, Rb, R1, R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.

Abstract: The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, R1, R2, R3, R7 and n of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formula II and sub-formula embodiments thereof, intermediates and processes and methods useful for the preparation of compounds of Formulas I-II.

Abstract: A security apparatus for securing a portable electronic device to an immovable object includes a head having a base. The head also includes a plurality of engagement elements extending from the base and configured to be inserted into an aperture of the portable electronic device. The plurality of engagement elements is movable relative to the body while inserted into the aperture to engage a portion of the portable electronic device. The head further includes a linear element positioned between the plurality of engagement elements. The linear element is movable relative to the plurality of engagement elements to push the plurality of engagement elements radially outward. The security apparatus also includes a security device attached to the head and configured to engage the immovable object.

Abstract: The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, each of Ra, Rb, R1, R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.