Patents by Inventor Ryan Whitford

Ryan Whitford has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250137010
    Abstract: Compositions and methods are capable of modulating male fertility in a plant. Compositions comprise polynucleotides and polypeptides, and fragments and variants thereof, which modulate male fertility. Expression cassettes comprise a male-fertility polynucleotide, or fragment or variant thereof, operably linked to a promoter, wherein expression of the polynucleotide modulates the male fertility of a plant. The level and/or activity of a polynucleotide that influences male fertility is modulated in a plant or plant part. Regulatory sequences drive expression in a male-tissue-preferred manner and may be targets to downregulate an operably linked gene. Methods to track mutations that induce nuclear recessive male sterility in subsequent selfing and crossing of wheat lines containing the mutations are also provided. Male-sterile plants may be maintained by pollinating with a maintainer plant.
    Type: Application
    Filed: November 8, 2024
    Publication date: May 1, 2025
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC
    Inventors: MARC C ALBERTSEN, UTE BAUMANN, ANDREW MARK CIGAN, MANJIT SINGH, ELISE TUCKER, RYAN WHITFORD
  • Patent number: 12163145
    Abstract: Compositions and methods are capable of modulating male fertility in a plant. Compositions comprise polynucleotides and polypeptides, and fragments and variants thereof, which modulate male fertility. Expression cassettes comprise a male-fertility polynucleotide, or fragment or variant thereof, operably linked to a promoter, wherein expression of the polynucleotide modulates the male fertility of a plant. The level and/or activity of a polynucleotide that influences male fertility is modulated in a plant or plant part. Regulatory sequences drive expression in a male-tissue-preferred manner and may be targets to downregulate an operably linked gene. Methods to track mutations that induce nuclear recessive male sterility in subsequent selfing and crossing of wheat lines containing the mutations are also provided. Male-sterile plants may be maintained by pollinating with a maintainer plant.
    Type: Grant
    Filed: April 29, 2021
    Date of Patent: December 10, 2024
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Marc C Albertsen, Ute Baumann, Andrew Mark Cigan, Manjit Singh, Elise Tucker, Ryan Whitford
  • Publication number: 20240360470
    Abstract: Compositions and methods are provided for genome modification of a nucleotide sequence located in or near a male fertility gene of Ms1 or Ms5 in the genome of a plant cell or plant to produce a male-sterile plant. In some examples, the methods and compositions employ a guide RNA/Cas endonuclease system for modifying or altering target sites located in or near a male fertility gene of Ms1 or Ms5 in the genome of a plant cell, plant or seed to produce a male-sterile plant. Also provided are compositions and methods employing a guide polynucleotide/Cas endonuclease system for genome modification a nucleotide sequence located in or near a male fertility gene of Ms1 or Ms5 in the genome of a plant cell to produce a male-sterile plant. Compositions and methods are also provided for restoring fertility to a Ms1 or Ms5 nucleotide sequence to a male-sterile Ms1 or Ms5 plant.
    Type: Application
    Filed: July 8, 2024
    Publication date: October 31, 2024
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: UTE BAUMANN, ANDREW MARK CIGAN, MARGARET ANNE PALLOTTA, MANJIT SINGH, RADOSLAW SUCHECKI, NATHAN SPENCER WATSON-HAIGH, RYAN WHITFORD
  • Patent number: 12054732
    Abstract: Compositions and methods are provided for genome modification of a nucleotide sequence located in or near a male fertility gene of Ms1 or Ms5 in the genome of a plant cell or plant to produce a male-sterile plant. In some examples, the methods and compositions employ a guide RNA/Cas endonuclease system for modifying or altering target sites located in or near a male fertility gene of Ms1 or Ms5 in the genome of a plant cell, plant or seed to produce a male-sterile plant. Also provided are compositions and methods employing a guide polynucleotide/Cas endonuclease system for genome modification a nucleotide sequence located in or near a male fertility gene of Ms1 or Ms5 in the genome of a plant cell to produce a male-sterile plant. Compositions and methods are also provided for restoring fertility to a Ms1 or Ms5 nucleotide sequence to a male-sterile Ms1 or Ms5 plant produced using the methods and compositions described herein.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: August 6, 2024
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Ute Baumann, Andrew Mark Cigan, Margaret Anne Pallotta, Manjit Singh, Radoslaw Suchecki, Nathan Spencer Watson-Haigh, Ryan Whitford
  • Publication number: 20240018538
    Abstract: Compositions and methods are capable of modulating male fertility in a plant. Compositions comprise polynucleotides and polypeptides, and fragments and variants thereof, which modulate male fertility. Expression cassettes comprise a male-fertility polynucleotide, or fragment or variant thereof, operably linked to a promoter, wherein expression of the polynucleotide modulates the male fertility of a plant. Regulatory sequences drive expression in a male-tissue-preferred manner and may be targets to downregulate an operably-linked gene. Mutations that induce nuclear recessive male sterility in subsequent selfing and crossing of wheat lines containing the mutations may be tracked. Male-sterile plants may be maintained by crossing with a maintainer plant. Hybrids can be produced using the male-sterile plants.
    Type: Application
    Filed: July 31, 2023
    Publication date: January 18, 2024
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: MARC C. ALBERTSEN, UTE BAUMANN, ANDREW MARK CIGAN, MANJIT SINGH, ELISE TUCKER, RYAN WHITFORD
  • Patent number: 11761016
    Abstract: Compositions and methods are capable of modulating male fertility in a plant. Compositions comprise polynucleotides and polypeptides, and fragments and variants thereof, which modulate male fertility. Expression cassettes comprise a male-fertility polynucleotide, or fragment or variant thereof, operably linked to a promoter, wherein expression of the polynucleotide modulates the male fertility of a plant. Regulatory sequences drive expression in a male-tissue-preferred manner and may be targets to downregulate an operably-linked gene. Mutations that induce nuclear recessive male sterility in subsequent selfing and crossing of wheat lines containing the mutations may be tracked. Male-sterile plants may be maintained by crossing with a maintainer plant. Hybrids can be produced using the male-sterile plants.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: September 19, 2023
    Inventors: Marc C Albertsen, Ute Baumann, Andrew Mark Cigan, Manjit Singh, Elise Tucker, Ryan Whitford
  • Publication number: 20210254096
    Abstract: Compositions and methods are capable of modulating male fertility in a plant. Compositions comprise polynucleotides and polypeptides, and fragments and variants thereof, which modulate male fertility. Expression cassettes comprise a male-fertility polynucleotide, or fragment or variant thereof, operably linked to a promoter, wherein expression of the polynucleotide modulates the male fertility of a plant. The level and/or activity of a polynucleotide that influences male fertility is modulated in a plant or plant part. Regulatory sequences drive expression in a male-tissue-preferred manner and may be targets to downregulate an operably linked gene. Methods to track mutations that induce nuclear recessive male sterility in subsequent selfing and crossing of wheat lines containing the mutations are also provided. Male-sterile plants may be maintained by pollinating with a maintainer plant.
    Type: Application
    Filed: April 29, 2021
    Publication date: August 19, 2021
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: MARC C ALBERTSEN, UTE BAUMANN, ANDREW MARK CIGAN, MANJIT SINGH, ELISE TUCKER, RYAN WHITFORD
  • Publication number: 20210222192
    Abstract: Compositions and methods are provided for genome modification of a nucleotide sequence located in or near a male fertility gene of Ms1 or Ms5 in the genome of a plant cell or plant to produce a male-sterile plant. In some examples, the methods and compositions employ a guide RNA/Cas endonuclease system for modifying or altering target sites located in or near a male fertility gene of Ms1 or Ms5 in the genome of a plant cell, plant or seed to produce a male-sterile plant. Also provided are compositions and methods employing a guide polynucleotide/Cas endonuclease system for genome modification a nucleotide sequence located in or near a male fertility gene of Ms1 or Ms5 in the genome of a plant cell to produce a male-sterile plant. Compositions and methods are also provided for restoring fertility to a Ms1 or Ms5 nucleotide sequence to a male-sterile Ms1 or Ms5 plant produced using the methods and compositions described herein.
    Type: Application
    Filed: December 10, 2018
    Publication date: July 22, 2021
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: UTE BAUMANN, ANDREW MARK CIGAN, MARGARET ANNE PALLOTTA, MANJIT SINGH, RADOSLAW SUCHECKI, NATHAN SPENCER WATSON-HAIGH, RYAN WHITFORD
  • Patent number: 11015209
    Abstract: Compositions and methods are capable of modulating male fertility in a plant. Compositions comprise polynucleotides and polypeptides, and fragments and variants thereof, which modulate male fertility. Expression cassettes comprise a male-fertility polynucleotide, or fragment or variant thereof, operably linked to a promoter, wherein expression of the polynucleotide modulates the male fertility of a plant. The level and/or activity of a polynucleotide that influences male fertility is modulated in a plant or plant part. Regulatory sequences drive expression in a male-tissue-preferred manner and may be targets to downregulate an operably linked gene. Methods to track mutations that induce nuclear recessive male sterility in subsequent selfing and crossing of wheat lines containing the mutations are also provided. Male-sterile plants may be maintained by pollinating with a maintainer plant.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: May 25, 2021
    Inventors: Marc C Albertsen, Ute Baumann, Andrew Mark Cigan, Manjit Singh, Elise Tucker, Ryan Whitford
  • Publication number: 20200087678
    Abstract: Compositions and methods are capable of modulating male fertility in a plant. Compositions comprise polynucleotides and polypeptides, and fragments and variants thereof, which modulate male fertility. Expression cassettes comprise a male-fertility polynucleotide, or fragment or variant thereof, operably linked to a promoter, wherein expression of the polynucleotide modulates the male fertility of a plant. Regulatory sequences drive expression in a male-tissue-preferred manner and may be targets to downregulate an operably-linked gene. Mutations that induce nuclear recessive male sterility in subsequent selfing and crossing of wheat lines containing the mutations may be tracked. Male-sterile plants may be maintained by crossing with a maintainer plant. Hybrids can be produced using the male-sterile plants.
    Type: Application
    Filed: November 27, 2019
    Publication date: March 19, 2020
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: MARC C ALBERTSEN, UTE BAUMANN, ANDREW MARK CIGAN, MANJIT SINGH, ELISE TUCKER, RYAN WHITFORD
  • Patent number: 10519464
    Abstract: Compositions and methods are capable of modulating male fertility in a plant. Compositions comprise polynucleotides and polypeptides, and fragments and variants thereof, which modulate male fertility. Expression cassettes comprise a male-fertility polynucleotide, or fragment or variant thereof, operably linked to a promoter, wherein expression of the polynucleotide modulates the male fertility of a plant. Regulatory sequences drive expression in a male-tissue-preferred manner and may be targets to downregulate an operably-linked gene. Mutations that induce nuclear recessive male sterility in subsequent selfing and crossing of wheat lines containing the mutations may be tracked. Male-sterile plants may be maintained by crossing with a maintainer plant. Hybrids can be produced using the male-sterile plants.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: December 31, 2019
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Marc C Albertsen, Ute Baumann, Andrew Mark Cigan, Manjit Singh, Elise Tucker, Ryan Whitford
  • Publication number: 20170298383
    Abstract: Compositions and methods are capable of modulating male fertility in a plant. Compositions comprise polynucleotides and polypeptides, and fragments and variants thereof, which modulate male fertility. Expression cassettes comprise a male-fertility polynucleotide, or fragment or variant thereof, operably linked to a promoter, wherein expression of the polynucleotide modulates the male fertility of a plant. The level and/or activity of a polynucleotide that influences male fertility is modulated in a plant or plant part. Regulatory sequences drive expression in a male-tissue-preferred manner and may be targets to downregulate an operably linked gene. Methods to track mutations that induce nuclear recessive male sterility in subsequent selfing and crossing of wheat lines containing the mutations are also provided. Male-sterile plants may be maintained by pollinating with a maintainer plant.
    Type: Application
    Filed: September 21, 2015
    Publication date: October 19, 2017
    Inventors: MARC C. ALBERTSEN, UTE BAUMANN, ANDREW MARK CIGAN, MANJIT SINGH, ELISE TUCKER, RYAN WHITFORD
  • Publication number: 20160201084
    Abstract: Compositions and methods are capable of modulating male fertility in a plant. Compositions comprise polynucleotides and polypeptides, and fragments and variants thereof, which modulate male fertility. Expression cassettes comprise a male-fertility polynucleotide, or fragment or variant thereof, operably linked to a promoter, wherein expression of the polynucleotide modulates the male fertility of a plant. Regulatory sequences drive expression in a male-tissue-preferred manner and may be targets to downregulate an operably-linked gene. Mutations that induce nuclear recessive male sterility in subsequent selfing and crossing of wheat lines containing the mutations may be tracked. Male-sterile plants may be maintained by crossing with a maintainer plant. Hybrids can be produced using the male-sterile plants.
    Type: Application
    Filed: September 25, 2015
    Publication date: July 14, 2016
    Inventors: MARC C ALBERTSEN, UTE BAUMANN, ANDREW MARK CIGAN, MANJIT SINGH, ELISE TUCKER, RYAN WHITFORD
  • Patent number: 7767664
    Abstract: The present invention relates to a new class of plant growth regulators. In particular, the invention relates to fused azepinone derivative of general formula (I) or an agriculturally acceptable salt thereof wherein X is CO2R2 or H; Y is OH; NHNR3R4, NHNHC(?Z)NR5R6 or NHNHC(?Z)CR7R8R9; or X and Y together with the two carbon atoms to which they are attached form a ring of formula (A) and a method for treatment of plants with such compounds in order to induce growth regulating responses.
    Type: Grant
    Filed: April 30, 2005
    Date of Patent: August 3, 2010
    Assignee: Bayer CropScience AG
    Inventors: Henricus M. M. Bastiaans, Günter Donn, Nathalie Knittel, Arianna Martelletti, Richard Rees, Michael Schwall, Ryan Whitford
  • Publication number: 20100152044
    Abstract: The present invention relates to the use of a compound for plant growth regulation, preferably by application of the compound to plants, to the seeds from which they grow or to the locus in which they grow, in an effective plant growth regulating, preferably non-phytotoxic amount, which compound is a 3,4-disubstituted maleimide derivative of formula (I) or an agriculturally acceptable salt thereof, wherein: X is aryl or heteroaryl which groups are unsubstituted or substituted; Y is NH or a covalent bond; and Z is aryl or heteroaryl which groups are unsubstituted or substituted and a method for treatment of plants with such compounds in order to induce growth regulating responses.
    Type: Application
    Filed: April 30, 2005
    Publication date: June 17, 2010
    Applicant: Bayer CropScience GmbH
    Inventors: Henricus M.M. Bastiaans, Günter Donn, Nathalie Knittel, Arianna Martelletti, Richard Rees, Michael Schwall, Ryan Whitford
  • Publication number: 20080269055
    Abstract: The present invention relates to a new class of plant growth regulators. In particular, the invention relates to fused azepinone derivative of general formula (I) or an agriculturally acceptable salt thereof wherein X is CO2R2 or H; Y is OH; NHNR3R4, NHNHC(=Z)NR5R6 or NHNHC(=Z)CR7R8R9; or X and Y together with the two carbon atoms to which they are attached form a ring of formula (A) and a method for treatment of plants with such compounds in order to induce growth regulating responses.
    Type: Application
    Filed: April 30, 2005
    Publication date: October 30, 2008
    Applicant: Bayer CropScience GmbH
    Inventors: Henricus M. M. Bastiaans, Gunter Donn, Nathalie Knittel, Arianna Martelletti, Richard Rees, Michael Schwall, Ryan Whitford
  • Publication number: 20080227640
    Abstract: The present invention relates to the use of a compound for plant growth regulation, preferably by application of the compound to plants, to the seeds from which they grow or to the locus in which they grow, in an effective plant growth regulating, preferably non-phytotoxic amount, which compound is an indolinone derivative of formula (I) or an agriculturally acceptable salt thereof: wherein: X is NNHR2, NNHC(?S)NH—(C1-C6)alkyl or a formula (A): in which the point of attachment is the carbon atom marked 2, and a method for treatment of plants with such compounds in order to induce growth regulating responses.
    Type: Application
    Filed: April 30, 2005
    Publication date: September 18, 2008
    Applicant: Bayer CropScience GmbH
    Inventors: Henricus M. M. Bastiaans, Gunter Donn, Nathalie Knittel, Arianna Martelletti, Richard Rees, Michael Schwall, Ryan Whitford
  • Publication number: 20080039321
    Abstract: The present invention relates to a new class of plant growth regulators. In particular, the invention relates 2-amino-6-oxypurine derivatives of general formula (I) or a salt thereof and a method for treatment of plants with such compounds in order to induce growth regulating responses.
    Type: Application
    Filed: April 30, 2005
    Publication date: February 14, 2008
    Inventors: Henricus Bastiaans, Gunter Donn, Nathalie Knittel, Arianna Martelletti, Richard Rees, Michael Schwall, Ryan Whitford
  • Publication number: 20070167329
    Abstract: The present invention relates to a new class of plant growth regulators. In particular, the invention relates to 2,4-diamino-5-substituted-thiazole derivatives of general formula (I); and a method for treatment of plants with such compounds in order to induce growth-regulating responses.
    Type: Application
    Filed: December 15, 2004
    Publication date: July 19, 2007
    Applicant: Bayer CropScience GmbH
    Inventors: Henricus Bastiaans, Gunter Donn, Nathalie Knittel, Arianna Martelletti, Richard Rees, Michael Schwall, Ryan Whitford