Patents by Inventor Ryo Nagashio

Ryo Nagashio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for assessing risk of hepatocellular carcinoma
    Patent number: 9447472
    Abstract: The present invention aims at providing a method for assessing risk of hepatocellular carcinoma with high sensitivity and specificity. Extracted were 30 regions containing 45 CpG sites which have DNA methylation levels significantly different between in normal liver tissue samples and in noncancerous liver tissue samples from patients with hepatocellular carcinoma. It was found that the noncancerous liver tissue samples from patients with HCC were able to be assessed for risk of hepatocellular carcinoma by setting cutoff values for distinguishing between the normal liver tissue samples and the noncancerous liver tissue samples from patients with HCC for the extracted 30 regions.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: September 20, 2016
    Assignee: NATIONAL CANCER CENTER
    Inventors: Yae Kanai, Eri Arai, Ryo Nagashio
  • METHOD FOR ASSESSING RISK OF HEPATOCELLULAR CARCINOMA
    Publication number: 20140017686
    Abstract: The present invention aims at providing a method for assessing risk of hepatocellular carcinoma with high sensitivity and specificity. Extracted were 30 regions containing 45 CpG sites which have DNA methylation levels significantly different between in normal liver tissue samples and in noncancerous liver tissue samples from patients with hepatocellular carcinoma. It was found that the noncancerous liver tissue samples from patients with HCC were able to be assessed for risk of hepatocellular carcinoma by setting cutoff values for distinguishing between the normal liver tissue samples and the noncancerous liver tissue samples from patients with HCC for the extracted 30 regions.
    Type: Application
    Filed: January 27, 2012
    Publication date: January 16, 2014
    Applicant: NATIONAL CANCER CENTER
    Inventors: Yae Kanai, Eri Arai, Ryo Nagashio