Patents by Inventor Ryo Okachi
Ryo Okachi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4760060Abstract: Carbacephem and cephem compounds represented by the formula: ##STR1## [Wherein X is S or CH.sub.2 ; n is an integer of 1 to 5; R.sub.1 is an unsubstituted or substituted heterocyclic group (where the heterocyclic group is a 5- or 6-membered heterocyclic group having 1 to 4 of O, S and N); R.sub.2 is a group represented by the formula: ##STR2## (where R.sub.4 is an unsubstituted or substituted phenyl or 2-aminothiazolyl) or a group represented by the formula: ##STR3## (where R.sub.5 is an unsubstituted or substituted lower alkyl); R.sub.3 is hydrogen, an alkali metal, an alkaline earth metal, an organic ammonium group or an ester residue, and R.sub.1 may be a quaternary ammonium group, where --CO.sub.2 R.sub.3 represents --CO.sub.2.sup.- ] have strong antibacterial activity against Gram-positive and Gram-negative bacteria, and are useful for treating various infections.Type: GrantFiled: November 15, 1985Date of Patent: July 26, 1988Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Kenichi Mochida, Takehiro Ogasa, Junichi Shimada, Tadahi Hirata, Kiyoshi Sato, Ryo Okachi
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Patent number: 4683220Abstract: Disclosed is a novel physiologically active substance, K-26, a process for preparation thereof and a pharmaceutical composition containing the same. The composition of matter, K-26, is useful as a hypotensive agent.Type: GrantFiled: September 26, 1986Date of Patent: July 28, 1987Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Masayuki Yamato, Hiroshi Kase, Isao Kawamoto, Masaji Kasai, Kunikatsu Shirahata, Takashi Deguchi, Katsuichi Shuto, Akira Karasawa, Ryo Okachi, Kiyoshi Nakayama
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Patent number: 4640919Abstract: Carbacephem compounds represented by the formula: ##STR1## [wherein R.sub.1 is a lower alkylsulfonyloxy, unsubstituted or substituted arylsulfonyloxy, azido, cyano, carbamoyloxy, unsubstituted or substituted heterocyclic thio ("heterocyclic" means a 5- or 6-membered heterocyclic group having 1 to 4 O, S or N atoms), unsubstituted or substituted lower alkylthio, or unsubstituted or substituted arylthio group; R.sub.2 and R.sub.3 are groups frequently used in the cephalosporin chemistry] have strong antibacterial activity against Gram-positive and Gram-negative bacteria, and are useful for curing various infections.Type: GrantFiled: February 19, 1985Date of Patent: February 3, 1987Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Kenichi Mochida, Takehiro Ogasa, Junichi Shimada, Tadashi Hirata, Kiyoshi Sato, Ryo Okachi
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Patent number: 4575497Abstract: 3, 3", 4"-Tri-O-acylspiramycin I represented by the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are the same or different groups, and at least one of the groups is a straight or branched chain alkylcarbonyl group represented by --COC.sub.m H.sub.2m+1 wherein m is an integer of 2-4 and the other group(s) are straight or branched chain alkylcarbonyl group(s) represented by --COC.sub.n H.sub.2n+1 wherein n is an integer of 1-4, and its pharmacologically acceptable acid addition salts.Type: GrantFiled: December 11, 1984Date of Patent: March 11, 1986Assignee: Kyowa Hakko Kogyo Co., LtdInventors: Satoshi Omura, Hiroshi Sano, Kinya Yamashita, Ryo Okachi
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Patent number: 4522812Abstract: Disclosed is a novel physiologically active substance K-4 which has a hypotensive activity, a process production thereof and a pharmaceutical composition containing the same.Type: GrantFiled: August 11, 1982Date of Patent: June 11, 1985Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Toshiro Koguchi, Hiroshi Kase, Isao Kawamoto, Masaji Kasai, Kunikatsu Shirahata, Ryo Okachi, Kiyoshi Nakayama
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Patent number: 4316957Abstract: The antibacterial compounds 7-deazaadenosine and 7-deazinosine are produced by fermentation of a new microorganism of the genus Micromonospora. At least one of the active substances is isolated from the culture medium.Type: GrantFiled: April 4, 1978Date of Patent: February 23, 1982Assignee: Abbott LaboratoriesInventors: Takashi Nara, Ryo Okachi, Isao Kawamoto, Tomoyasu Sato, Tetsuo Oka
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Patent number: 4310661Abstract: New antibacterial compounds, XK-62-3 and XK-62-4, are produced by fermentation of microorganisms belonging to the genus Micromonospora. The compounds are accumulated in the culture liquor and are isolated therefrom.Type: GrantFiled: December 23, 1980Date of Patent: January 12, 1982Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Takao Iida, Kunikatsu Shirahata, Shinzo Ishii, Ryo Okachi, Takashi Nara
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Patent number: 4298690Abstract: New antibacterial compounds, XK-62-3 and XK-62-4, are produced by fermentation of microorganisms belonging to the genus Micromonospora. The compounds are accumulated in the culture liquor and are isolated therefrom.Type: GrantFiled: May 16, 1978Date of Patent: November 3, 1981Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Takao Iida, Kunikatsu Shirahata, Shinzo Ishii, Ryo Okachi, Takashi Nara
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Patent number: 4216308Abstract: New antibiotic compounds, Fortimicin factors D and KE are produced by fermentation of microorganisms belonging to the genus Micromonospora. The antibiotic compounds are accumulated in the culture liquor and are isolated therefrom. A semisynthetic method of producing Fortimicin KE utilizing Fortimicin D is also disclosed.Type: GrantFiled: December 29, 1978Date of Patent: August 5, 1980Assignee: Abbott LaboratoriesInventors: Takao Iida, Kunikatsu Shirahata, Isao Matsubara, Masahiro Sugimoto, Shinzo Ishii, Ryo Okachi, Takashi Nara
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Patent number: 4209612Abstract: New antibiotic compounds, Fortimicin factors KF and KG are produced by fermentation of microorganisms belonging to the genus Micromonospora. The antibiotic compounds are accumulated in the culture liquor and are isolated therefrom.Type: GrantFiled: November 6, 1978Date of Patent: June 24, 1980Assignee: Abbott LaboratoriesInventors: Keiichi Takahashi, Takao Iida, Kunikatsu Shirahata, Masahiro Sugimoto, Shinzo Ishii, Ryo Okachi, Takashi Nara
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Patent number: 4162305Abstract: A novel antibacterial compound, XK-99, is produced by fermentation of an organism belonging to the genus Micromonospora. The compound is isolated from the microbial cells and culture liquor.Type: GrantFiled: March 29, 1978Date of Patent: July 24, 1979Assignee: Abbott LaboratoriesInventors: Takashi Nara, Ryo Okachi, Isao Kawamoto, Tomoyasu Sato, Tetsuo Oka
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Patent number: 4145253Abstract: New antibiotic compounds, Fortimicin factors D and KE are produced by fermentation of microorganisms belonging to the genus Micromonospora. The antibiotic compounds are accumulated in the culture liquor and are isolated therefrom. A semisynthetic method of producing Fortimicin KE utilizing Fortimicin D is also disclosed.Type: GrantFiled: October 27, 1977Date of Patent: March 20, 1979Assignee: Abbott LaboratoriesInventors: Takao Iida, Kunikatsu Shirahata, Isao Maisubara, Masahiro Sugimoto, Shinzo Ishii, Ryo Okachi, Takashi Nara
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Patent number: 4097428Abstract: A new antibiotic, Fortimicin C, is produced by fermentation of a microorganism belonging to the genus Micromonospora. The antibiotic is accumulated in the culture medium and is isolated therefrom.Type: GrantFiled: May 26, 1977Date of Patent: June 27, 1978Assignee: Abbott LaboratoriesInventors: Takashi Nara, Ryo Okachi, Mitsuyoshi Yamamoto, Yasuki Mori, Moriyuki Sato, Masahiro Sugimoto, Yoshiaki Shimizu
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Patent number: 4048015Abstract: A new antibiotic, Fortimicin C, is produced by fermentation of a microorganism belonging to the genus Micromonospora. The antibiotic is accumulated in the culture medium and is isolated therefrom.Type: GrantFiled: July 26, 1976Date of Patent: September 13, 1977Assignee: Abbott LaboratoriesInventors: Takashi Nara, Ryo Okachi, Mitsuyoshi Yamamoto, Yasuki Mori, Moriyuki Sato, Masahiro Sugimoto, Yoshiaki Shimizu
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Patent number: 4045298Abstract: The antibiotic XK-62-2 is produced by fermentation of microorganisms belonging to the genus Micromonospora. The antibiotic is accumulated in the culture liquor and is isolated therefrom.Type: GrantFiled: June 15, 1976Date of Patent: August 30, 1977Assignee: Abbott LaboratoriesInventors: Takashi Nara, Seigo Takasawa, Ryo Okachi, Isao Kawamoto, Mitsuyoshi Yamamoto, Seiji Sato, Tomoyasu Sato, Atsuko Morikawa
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Patent number: 4045610Abstract: A novel series of antibiotics designated the XK-88 series are produced by culturing a microorganism belonging to the genus Streptomyces in a nutrient medium and thereafter recovering the antibiotics from the culture liquor.Type: GrantFiled: October 17, 1975Date of Patent: August 30, 1977Assignee: Abbott LaboratoriesInventors: Takashi Nara, Seigo Takasawa, Ryo Okachi, Isao Kawamoto, Mitsuyoshi Yamamoto, Seiji Sato, Tomoyasu Sato, Atsuko Morikawa
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Patent number: 3976768Abstract: A new antibiotic, Fortimicin A, is produced by fermentation of a microorganism belonging to the genus Micromonospora. The antibiotic is accumulated in the culture medium and is isolated therefrom.Type: GrantFiled: July 22, 1974Date of Patent: August 24, 1976Assignee: Abbott LaboratoriesInventors: Takashi Nara, Seigo Takasawa, Ryo Okachi, Isao Kawamoto, Mitsuyoshi Yamamoto, Seiji Sato, Tomoyasu Sato
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Patent number: 3939043Abstract: A novel series of antibiotics designated the XK-88 series are produced by culturing a microorganism belonging to the genus Streptomyces in a nutrient medium and thereafter recovering the antibiotics from the culture liquor.BACKGROUND OF THE INVENTIONThe present invention relatees to novel antibiotics and a process for the production thereof. More specifically the present invention relates to novel antibiotics designated, XK-88-1, XK-88-2, XK-88-3 and XK-88-5 and a process for producing such antibiotics.Antibiotics which exhibit activity against a borad spectrum of bacteria are always in demand. To this end, a new species of microorganism has been isolated from soil located in Tajima-cho, Hofu-shi, Yamaguchi-ken, Japan. This new species, when cultured, produces a series of new antibiotics, the XK-88 series, all of which exhibit strong antibacterial activity against various Gram-positive and Gram-negative bacteria.Type: GrantFiled: October 21, 1974Date of Patent: February 17, 1976Assignee: Abbott LaboratoriesInventors: Takashi Nara, Seigo Takasawa, Ryo Okachi, Isao Kawamoto, Mitsuyoshi Yamamoto, Seiji Sato, Tomoyasu Sato, Atsuko Morikawa
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Patent number: 3931400Abstract: A new antibiotic, Fortimicin B, is produced by fermentation of a microorganism belonging to the genus Micromonospora. The antibiotic is accumulated in the culture medium and is isolated therefrom.Type: GrantFiled: April 5, 1974Date of Patent: January 6, 1976Assignee: Abbott LaboratoriesInventors: Takashi Nara, Seigo Takasawa, Ryo Okachi, Isao Kawamoto, Mitsuyoshi Yamamoto