Abstract: A method for producing a metabolically activated liver organoid, the method including culturing primary hepatocytes or hepatocyte-like cells in a differentiation medium to obtain a metabolically activated liver organoid, in which the differentiation medium is a medium including one or two selected from the group consisting of a growth hormone receptor agonist and a prolactin receptor agonist, and a glucocorticoid receptor agonist.

Abstract: A device is attached to the helmet by spanning a support belt that supports the device between base portions provided on left and right outer side surfaces at either a front portion or a rear portion of a helmet body via a clip that engages with the base portions. The base portions are opened in a lateral direction of the helmet body and have a locking portion formed at an opening edge, and the clip includes a hook portion that is configured to engage the clip with the locking portion to be pivotable and a connecting portion that is connected to the support belt. The clip is pivotable with the hook portion locked in the locking portion as a fulcrum. A stopper that is engaged with an engaging portion provided on an outer side surface of the base portions is provided on an inner side surface of the connecting portion.

Abstract: It is an object of the present invention to provide an acrylic copolymer for providing a highly heat-resistant rubber material that shows a small rate of change in strength without loss of elongation, even under a high-temperature condition over a long period, and a composition containing the acrylic copolymer. The present invention provides an acrylic copolymer comprising a structural unit (A) derived from a monomer containing a structure having a maleimide skeleton, a structural unit (B) derived from an acrylic acid alkyl ester and/or a structural unit (B) derived from an acrylic acid alkoxyalkyl ester, and a structural unit (C) derived from an unsaturated monomer having a crosslinking group; a composition comprising the acrylic copolymer and a crosslinking group; and a rubber material produced from the composition.

Abstract: A halogen, antimony, phenolic-free thermosetting epoxy resin composition is provided. The halogen, antimony, phenolic-free epoxy resin composition comprises an epoxy resin, a curing agent, a catalyst and a fire-resistive additive. When the epoxy resin composition is impregnated into a fabric such as a fiberglass fabric and molded into a panel, the panel has an OSU two minute total heat release of less than 40 KW-min/m2 and an OSU peak heat release rate of less than 40 kW/m2. The epoxy resin composition can be combined with a fabric such as a fiberglass fabric to form a prepreg. The prepreg, when in contact with at least one honeycomb structure, can be cured to form composite materials including panels for use in aerospace interior applications.

Abstract: An object of the invention is to provide a pharmaceutical composition, in particular, an oral pharmaceutical composition useful for, for example, preventing and/or treating a kidney disease, in particular, a disease caused by glomerular injury.

Abstract: There is provided a method for more easily producing an acrylic rubber capable of providing a crosslinked rubber having excellent water resistance. A method for producing an acrylic rubber comprising the steps of subjecting a monomer to emulsion polymerization to obtain a polymerized emulsion; mixing the polymerized emulsion with a coagulant to obtain a water-containing crumb; and water-washing the water-containing crumb, wherein, in the step of water-washing the water-containing crumb, the water-containing crumb is water-washed until an electrical conductivity of the washing water after water-washing the water-containing crumb becomes 6.0 mS/cm or less.

Abstract: An organoid production method includes culturing a human stem cell in a culture medium containing a cyclic peptide having an amino acid sequence set forth in Formula (1) or a pharmaceutically acceptable salt of the cyclic peptide [in Formula (1), X1 to X6 each represent a specific modified amino acid, X7 represents any amino acid residue, R is absent or represents a C-terminal modification group, n is an integer of 0 or 1, PeG is N-(2-phenylethyl)-glycine, and Nal1 is ?-(1-naphthyl)-L-alanine].

Abstract: A biomimetic system includes: a container; and a human cholangiocyte-like cell-containing membrane, in which the human cholangiocyte-like cell-containing membrane includes a permeable base plate and a two-dimensional tissue of human cholangiocyte-like cells stacked on one surface of the permeable base plate, the human cholangiocyte-like cell-containing membrane divides the container into a first compartment and a second compartment, a one surface side of the permeable base plate is exposed in the first compartment, the other surface side of the permeable base plate is exposed in the second compartment, the human cholangiocyte-like cells express P-gp, and an efflux ratio calculated by Formula (1) is 1.5 or more, efflux ratio=(permeation rate of rhodamine 123 that permeates from the second compartment to the first compartment)/(permeation rate of rhodamine 123 that permeates the second compartment from the first compartment) . . .

Abstract: The present invention relates to a tobacco plant and the like. The tobacco plant of the present invention contains nitrate reductase in which an amino acid residue corresponding to position 525 in an amino acid sequence corresponding to SEQ ID NO: 2 or 4 is mutated from proline to an amino acid residue other than proline. In one embodiment, the tobacco plant has one or more properties of the following (a) to (c): (a) the activity of the nitrate reductase under the dark condition is 80% or more of the activity of the nitrate reductase under the light condition; (b) an individual is essentially equivalent to a control in growth; and/or (c) nitric acid decreases as compared with the control, wherein the control is a tobacco plant containing nitrate reductase consisting of the amino acid sequence of SEQ ID NO: 2 or 4.

Abstract: The present invention aims to provide an acrylic copolymer capable of maintaining excellent storage stability in the uncrosslinked state even after long-term exposure to high temperatures, and a crosslinked acrylic rubber product produced from the acrylic copolymer which maintains good normal-state properties and good water resistance. The present invention is based on the finding that an acrylic copolymer produced by polymerizing a liquid mixture of an alkoxyalkyl (meth)acrylate containing an alkoxyalkyl group and a crosslinkable monomer containing a carboxy group has excellent storage stability and that a crosslinked product produced from the acrylic copolymer has good normal-state properties and good water resistance.

Abstract: Provided is a communication device and a control method, according to which in a configuration in which a plurality of processing units having a master-subordinate relationship therebetween, processing for controlling an abnormality and the like that has occurred in the subordinate processing unit can be performed by the master processing unit. A communication device includes a master processing unit and a subordinate processing unit, and the subordinate processing unit performs processing regarding communication, the master processing unit controls activation of the subordinate processing unit, the subordinate processing unit periodically transmits a signal to the master processing unit, and the master processing unit controls an operation of the subordinate processing unit in accordance with the signal that is periodically transmitted by the subordinate processing unit.

Abstract: There is provided a method for more easily producing an acrylic rubber capable of providing a crosslinked rubber having excellent water resistance. A method for producing an acrylic rubber comprising the steps of subjecting a monomer to emulsion polymerization to obtain a polymerized emulsion; mixing the polymerized emulsion with a coagulant to obtain a water-containing crumb; and water-washing the water-containing crumb, wherein, in the step of water-washing the water-containing crumb, the water-containing crumb is water-washed until an electrical conductivity of the washing water after water-washing the water-containing crumb becomes 6.0 mS/cm or less.

Abstract: Disclosed is a wet friction member for use in a wet clutch or a wet brake that has improved heat conductivity and tends not to damage a mating plate which is engaged with it to improve the endurance of the mating plate. The wet friction member 1 includes base paper formed from a fiber base material and a filler and a binder for curing the base paper. The base paper contains a carbon-based material and does not contain diatomaceous earth.

Abstract: The present invention provides an improvement of sensitivity in immunological measurement of tau protein. Specifically, the present invention provides an antibody conjugate comprising two or more kinds of anti-tau protein antibodies bound to a carrier.

Abstract: It is an object of the present invention to provide an acrylic copolymer for providing a highly heat-resistant rubber material that shows a small rate of change in strength without loss of elongation, even under a high-temperature condition over a long period, and a composition containing the acrylic copolymer. The present invention provides an acrylic copolymer comprising a structural unit (A) derived from a monomer containing a structure having a maleimide skeleton, a structural unit (B) derived from an acrylic acid alkyl ester and/or a structural unit (B) derived from an acrylic acid alkoxyalkyl ester, and a structural unit (C) derived from an unsaturated monomer having a crosslinking group; a composition comprising the acrylic copolymer and a crosslinking group; and a rubber material produced from the composition.

Abstract: The in-vehicle communication device includes a CAN communication unit, an Ethernet communication unit, a controller that controls communication by the CAN communication unit and the Ethernet communication unit, a first voltage output unit that outputs a first voltage, and a second voltage output unit that outputs a second voltage lower than the first voltage. The second voltage output is applied to the Ethernet communication unit. The first voltage output by the first voltage output unit and the second voltage output by the second voltage output unit are applied to the CAN communication unit. An opening/closing unit is provided between the second voltage output unit and the Ethernet communication unit. When a predetermined operation in the vehicle has been detected, the controller puts the opening/closing unit into an open state and cuts off the supply of power from the second voltage output unit to the Ethernet communication unit.

Abstract: Provided is a communication device and a control method, according to which in a configuration in which a plurality of processing units having a master-subordinate relationship therebetween, processing for controlling an abnormality and the like that has occurred in the subordinate processing unit can be performed by the master processing unit. A communication device includes a master processing unit and a subordinate processing unit, and the subordinate processing unit performs processing regarding communication, the master processing unit controls activation of the subordinate processing unit, the subordinate processing unit periodically transmits a signal to the master processing unit, and the master processing unit controls an operation of the subordinate processing unit in accordance with the signal that is periodically transmitted by the subordinate processing unit.

Abstract: A communication device comprises a connector to which a communication line is to be connected for sending and receiving a control signal concerning charge control between a transportation apparatus and a charging apparatus, a modem outputting a modulated signal obtained by modulating information to be sent and demodulating the modulated signal input, and a first internal communication line and a second internal communication line each being connected to the connector and the modem, the first internal communication line and the second internal communication line respectively being for sending the modulated signal and being for receiving the modulated signal, and sends and receives the modulated signal by superposing the modulated signal on the control signal.

Abstract: The in-vehicle communication device includes a CAN communication unit, an Ethernet communication unit, a controller that controls communication by the CAN communication unit and the Ethernet communication unit, a first voltage output unit that outputs a first voltage, and a second voltage output unit that outputs a second voltage lower than the first voltage. The second voltage output is applied to the Ethernet communication unit. The first voltage output by the first voltage output unit and the second voltage output by the second voltage output unit are applied to the CAN communication unit. An opening/closing unit is provided between the second voltage output unit and the Ethernet communication unit. When a predetermined operation in the vehicle has been detected, the controller puts the opening/closing unit into an open state and cuts off the supply of power from the second voltage output unit to the Ethernet communication unit.

Abstract: An in-vehicle relay device to which a plurality of communication lines installed in a vehicle are connectable performs processing for relaying communication between the communication lines, the device includes: a processor that includes an acquisition unit that acquires an update program for updating a program executed by an in-vehicle device connected to one of the communication lines and an update processing unit that performs processing for updating a program by transmitting an update program acquired by the acquisition unit to the in-vehicle device; a communication IC that performs, by executing a communication program, processing relating to communication performed via the communication lines; and a shared memory that is accessible by the processor and the communication IC, wherein an update program acquired by the acquisition unit of the processor and the communication program executed by the communication IC are stored in the shared memory.