Abstract: A semiconductor device includes a semiconductor module having a wiring board, semiconductor assemblies that include a multilayer substrate on which semiconductor elements are mounted, and a sealing part; a cooler; and a heat conduction sheet which is placed between the semiconductor module and the mounting surface of the cooler and which is in contact with the bottom surfaces of the multilayer substrates. The heat conduction sheet has recesses corresponding to at least parts of the outer edges of second electrically conductive plates provided on the bottoms of the multilayer substrates.

Abstract: An agent for inhibiting the action of a target RNA based on RNA interference and ASO with a passenger strand and a guide strand for a target RNA, wherein both ends of double-stranded RNA formed pairing of the passenger strand and the guide strand are blunt ends, and one or two or more selected from the group consisting of the units represented by formula (1) and formula (2) below at the following positions (a) and (b): (a) 5? end side and 3? end side of the passenger strand, (b) 3? end side of the guide strand (in which X represents an oxygen atom or sulfur atom), (in which X represents an oxygen atom or sulfur atom).

Abstract: A microneedle set including a microneedle injection device that introduces a liquid to a skin of a body part, and a piercing assisting tool fixable to the body part. The microneedle injection device includes a hollow needle shaped body having a projection in an end portion thereof and a through hole connected to the projection such that the liquid passes through the through hole and is released from a tip portion of the projection, and a supply device that supplies the liquid to the hollow needle shaped body. The piercing assisting tool includes a fixing part which has an aperture formed therein and fixes a position of the aperture on the body part, and a cover connected to a peripheral portion of the aperture such that the aperture is opened or closed by the cover.

Abstract: A needle-shaped body including a support section having a tubular shape with a center axis being a reference line, the support section having a proximal end and a distal end, a support substrate positioned in the support section and movable in a direction along the reference line, a needle section positioned on a main surface of the support substrate and protruding in a direction from the proximal end toward the distal end, a connecting section that detachably attaches the support substrate to the support section, and a guiding section that guides the support substrate along the reference line.

Abstract: A method of manufacturing a needle shaped body includes forming on a surface of a substrate a needle shaped portion having a bottomed hole that extends from a tip to the substrate, contacting the tip of the needle shaped portion with a surface of a liquid in an atmosphere at a first pressure lower than atmospheric pressure, increasing the first pressure to a second pressure while the tip is in contact with the surface of the liquid such that the liquid is filled into the bottomed hole, and freeze-drying the liquid filled in the bottomed hole.

Abstract: An administration device that can change a puncture depth depending on the thickness of the skin when a needle-shaped body has projections of the identical length. The administration device includes a needle-shaped body having a substrate and a projection protruding from one surface of the substrate, and a puncture depth adjustment section disposed on the one surface and having at least one film member that is detachable from the needle-shaped body.

Abstract: A needle-shaped body including a support section having a tubular shape with a center axis being a reference line, the support section having a proximal end and a distal end, a support substrate positioned in the support section and movable in a direction along the reference line, a needle section positioned on a main surface of the support substrate and protruding in a direction from the proximal end toward the distal end, a connecting section that detachably attaches the support substrate to the support section, and a guiding section that guides the support substrate along the reference line.

Abstract: A microneedle set including a microneedle injection device that introduces a liquid to a skin of a body part, and a piercing assisting tool fixable to the body part. The microneedle injection device includes a hollow needle shaped body having a projection in an end portion thereof and a through hole connected to the projection such that the liquid passes through the through hole and is released from a tip portion of the projection, and a supply device that supplies the liquid to the hollow needle shaped body. The piercing assisting tool includes a fixing part which has an aperture formed therein and fixes a position of the aperture on the body part, and a cover connected to a peripheral portion of the aperture such that the aperture is opened or closed by the cover.

Abstract: A transdermal administration device including an administering part including a substrate having a first surface, and at least one projection protruding from the first surface. The projection has a shape which extends along the first surface and includes one linear top edge which is located away from the first surface and has a first end and a second end, two primary lateral faces which share the one linear top edge and have lateral edges each individually connecting the first surface with the first end, and a secondary lateral face which has the lateral edges in common with the respective two primary lateral faces and forms one corner together with the two primary lateral faces. One of the lateral edge and the top edge on the primary lateral face form an obtuse angle, and the two lateral edges on the secondary lateral face form an acute angle.

Abstract: A method of manufacturing a needle shaped body includes forming on a surface of a substrate a needle shaped portion having a bottomed hole that extends from a tip to the substrate, contacting the tip of the needle shaped portion with a surface of a liquid in an atmosphere at a first pressure lower than atmospheric pressure, increasing the first pressure to a second pressure while the tip is in contact with the surface of the liquid such that the liquid is filled into the bottomed hole, and freeze-drying the liquid filled in the bottomed hole.

Abstract: A nucleic acid extraction kit, which enables the nucleic acid extraction operation to be accomplished safely without causing contamination, and in which the complex preparation of reagents and the disposal treatments that are performed before and after the nucleic acid extraction operation can be performed rapidly and simply, with the extraction performed in an automated manner. The nucleic acid extraction kit includes: a container including reagent wells that each store at least a reagent, a sample well into which a biological sample is introduced, a waste liquid well, and a collection well in which an extracted nucleic acid is collected, and an extraction filter cartridge equipped with an extraction filter for separating and extracting a nucleic acid from the biological sample, wherein the extraction filter cartridge is formed in a manner that enables the extraction filter cartridge to be supported on the waste liquid well and the collection well.

Abstract: A nucleic acid extraction kit, which enables the nucleic acid extraction operation to be accomplished safely without causing contamination, and in which the complex preparation of reagents and the disposal treatments that are performed before and after the nucleic acid extraction operation can be performed rapidly and simply, with the extraction performed in an automated manner. The nucleic acid extraction kit includes: a container including reagent wells that each store at least a reagent, a sample well into which a biological sample is introduced, a waste liquid well, and a collection well in which an extracted nucleic acid is collected, and an extraction filter cartridge equipped with an extraction filter for separating and extracting a nucleic acid from the biological sample, wherein the extraction filter cartridge is formed in a manner that enables the extraction filter cartridge to be supported on the waste liquid well and the collection well.

Abstract: A nucleic acid extraction kit, which enables the nucleic acid extraction operation to be accomplished safely without causing contamination, and in which the complex preparation of reagents and the disposal treatments that are performed before and after the nucleic acid extraction operation can be performed rapidly and simply, with the extraction performed in an automated manner. The nucleic acid extraction kit includes: a container including reagent wells 2 to 9 that each store at least a reagent, a sample well 13 into which a biological sample is introduced, a waste liquid well, and a collection well 11 in which an extracted nucleic acid is collected, and an extraction filter cartridge 12 equipped with an extraction filter for separating and extracting a nucleic acid from the biological sample, wherein the extraction filter cartridge is formed in a manner that enables the extraction filter cartridge to be supported on the waste liquid well and the collection well.

Abstract: A microarray originally developed for analyzing intracellular RNA expressions can be used to easily load polynucleotides onto a chip and to instantaneously determine polynucleotides (aptamers) capable of binding to a target molecule. Namely, the present inventors discovered that a microarray can be used to rapidly and efficiently obtain aptamers that bind to a target molecule.

Abstract: There is disclosed a process for detection of DNA methylation at CpG sites using nucleic acid arrays and preferably microarrays. Specifically, there is disclosed a process for directly generating a reference sample from the sample to be tested and detecting methylation at large numbers of CpG island sites simultaneously.