Patents by Inventor Ryoichiro Murashima

Ryoichiro Murashima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6475506
    Abstract: Disclosed is an infusion preparation for nutrient supply use. It comprises a sugar, amino acids, electrolytes and a fat emulsion. It has an excellent shelf life without causing precipitation, denaturation and the like in spite of the simultaneous presence of these components. Also disclosed is a container filled with infusion liquids comprising a first and a second compartment separated from each other by a separation means, wherein an infusion liquid containing a fat emulsion and a sugar is included in the first compartment and another infusion liquid containing amino acids and electrolytes is included in the second compartment. Further disclosed are an infusion preparation comprising a fat emulsion and a sugar, and an infusion preparation comprising amino acids and electrolytes.
    Type: Grant
    Filed: February 10, 1999
    Date of Patent: November 5, 2002
    Assignee: Yoshitomi Pharmaceutical
    Inventors: Tadaaki Inoue, Hideto Kodaira, Yoshihito Nawa, Ryoichiro Murashima, Shunichi Abe, Kazumasa Yokoyama
  • Patent number: 5993863
    Abstract: The present invention aims at providing an alimentative infusion liquid which has improved stability and preservability and can be administered through a peripheral vein. The infusion liquid contains sugars, amino acids, electrolytes and a fat emulsion at a specific mixing ratio and has a specific pH value and a titratable acidity. The alimentative infusion liquid of the present invention containing the above-described components has good preservability without suffering from precipitation, denaturation and the like problems. Further, since the pH value is adjusted to a specific level and the titratable acidity is retained low, administration of the infusion liquid through a peripheral vein does not cause troubles such as angialiga.
    Type: Grant
    Filed: October 7, 1997
    Date of Patent: November 30, 1999
    Assignee: Yoshitomi Pharmaceutical Industries, Ltd.
    Inventors: Masahiro Kikuchi, Yoshihiko Okutani, Tadaaki Inoue, Ryoichiro Murashima, Shunichi Abe, Hiroshi Koshiba, Hiroshi Shibata, Shunichiro Ishii, Yoshiyasu Kawabata, Kazumasa Yokoyama
  • Patent number: 5972367
    Abstract: Disclosed is an infusion preparation for nutrient supply use. It comprises a sugar, amino acids, electrolytes and a fat emulsion. It has an excellent shelf life without causing precipitation, denaturation and the like in spite of the simultaneous presence of these components. Also disclosed is a container filled with infusion liquids comprising a first and a second compartments separated from each other by a separation means, wherein an infusion liquid containing a fat emulsion and a sugar is included in the first compartment and another infusion liquid containing amino acids and electrolytes is included in the second compartment. Further disclosed are an infusion preparation comprising a fat emulsion and a sugar, and an infusion preparation comprising amino acids and electrolytes.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 26, 1999
    Assignee: The Green Cross Corporation
    Inventors: Tadaaki Inoue, Hideto Kodaira, Yoshihito Nawa, Ryoichiro Murashima, Shunichi Abe, Kazumasa Yokoyama
  • Patent number: 5674527
    Abstract: Disclosed is an infusion preparation for nutrient supply use. It comprises a sugar, amino acids, electrolytes and a fat emulsion. It has an excellent shelf life without causing precipitation, denaturation and the like in spite of the simultaneous presence of these components. Also disclosed is a container filled with infusion liquids comprising a first and a second compartments separated from each other by a separation means, wherein an infusion liquid containing a fat emulsion and a sugar is included in the first compartment and another infusion liquid containing amino acids and electrolytes is included in the second compartment. Further disclosed are an infusion preparation comprising a fat emulsion and a sugar, and an infusion preparation comprising amino acids and electrolytes.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 7, 1997
    Assignee: The Green Cross Corporation
    Inventors: Tadaaki Inoue, Hideto Kodaira, Yoshihito Nawa, Ryoichiro Murashima, Shunichi Abe, Kazumasa Yokoyama
  • Patent number: 5626880
    Abstract: Disclosed is an infusion preparation for nutrient supply use. It comprises a sugar, amino acids, electrolytes and a fat emulsion. It has an excellent shelf life without causing precipitation, denaturation and the like in spite of the simultaneous presence of these components. Also disclosed is a container filled with infusion liquids comprising a first and a second compartments separated from each other by a separation means, wherein an infusion liquid containing a fat emulsion and a sugar is included in the first compartment and another infusion liquid containing amino acids and electrolytes is included in the second compartment. Further disclosed are an infusion preparation comprising a fat emulsion and a sugar, and an infusion preparation comprising amino acids and electrolytes.
    Type: Grant
    Filed: January 22, 1996
    Date of Patent: May 6, 1997
    Assignee: The Green Cross Corporation
    Inventors: Tadaaki Inoue, Hideto Kodaira, Yoshihito Nawa, Ryoichiro Murashima, Shunichi Abe, Kazumasa Yokoyama
  • Patent number: 4252827
    Abstract: 50-95 Parts by weight of a perfluorocarbon compound such as perfluorodecalin, perfluoromethyldecalin, perfluoro alkylcyclohexanes having 3 to 5 carbon atoms in the alkyl, perfluoro alkyltetrahydrofurans having 5 to 7 carbon atoms in the alkyl, perfluoro alkyltetrahydropyrans having 4 to 6 carbon atoms in the alkyl, perfluoroalkanes having 9 to 11 carbon atoms, and 50-5 parts by weight of a perfluoro tert.-amine such as perfluoro tert.-alkylamines having 9-11 carbon atoms, perfluoro N-alkylpiperidines having 4 to 6 carbon atoms in the alkyl, and perfluoro N-alkylmorpholines having 5 to 7 carbon atoms in the alkyl are emulsified in an aqueous medium by the aid of a high-molecular-weight nonionic surfactant have a molecular weight of about 2,000 to 20,000, and phospholipids as emulsifying agent, and fatty acids having 8 to 22 carbon atoms or salts or monoglycerides thereof as emulsifying adjuvant.The resulting oxygen-transferable emulsion having a particle size of 0.05 to 0.25.mu.
    Type: Grant
    Filed: May 23, 1979
    Date of Patent: February 24, 1981
    Assignee: The Green Cross Corporation
    Inventors: Kazumasa Yokoyama, Kouichi Yamanouchi, Ryoichiro Murashima, Yoshio Tsuda
  • Patent number: 3993581
    Abstract: Oxygen-transferable perfluorocarbon compounds having 9 to 11 carbon atoms such as perfluorodecalin, perfluoro(C.sub.3.sub.-5 -alkylcyclohexanes), perfluoro(C.sub.4.sub.-6 -alkyl tetrahydropyrans), perfluoro(C.sub.5.sub.-7 -alkyltetrahydrofurans), perfluoro(C.sub.5.sub.-7 -alkylmorpholins) and perfluoro(C.sub.9.sub.-11 -trialkylamines) are emulsified in a physiologically acceptable aqueous solution such as Ringer's solution by the aid of a phospholipid as emulsifier and a fatty acid of 8 to 22 carbon atoms, alkali metal salt or monoglyceride thereof as emulsifying adjuvant. The emulsion is stable for a considerable period of time and contains particles having a particle size ranging from 0.05 to 0.3 .mu.. It is usable as a blood substitute or a perfurate for preservation of the internal organs.
    Type: Grant
    Filed: July 2, 1974
    Date of Patent: November 23, 1976
    Assignee: The Green Cross Corporation
    Inventors: Kazumasa Yokoyama, Koichi Yamanouchi, Ryoichiro Murashima, Ryozo Watanabe
  • Patent number: 3962439
    Abstract: Oxygen-transferable perfluorocarbon compounds having 9 to 11 carbon atoms such as perfluorodecalin, perfluoro(C.sub.3-5 -alkylcyclohexanes), perfluoro(C.sub.4-6 -alkyl tetrahydropyrans), perfluoro(C.sub.5-7 -alkyltetrahydrofurans), perfluoro(C.sub.5-7 -alkylmorpholins) and perfluoro(C.sub.9-11 -trialkylamines) are emulsified in a physiologically acceptable aqueons solution such as Ringer's solution by the aid of a phospholipid as emulsifier and a fatty acid of 8 to 22 carbon atoms, alkali metal salt or monoglyceride thereof as emulsifying adjuvant. The emulsion is stable for a considerable period of time and contains particles having a particle size ranging from 0.05 to 0.3 .mu.. It is usable as a blood substitute or a perfusate for preservation of the internal organs.
    Type: Grant
    Filed: February 4, 1974
    Date of Patent: June 8, 1976
    Assignee: The Green Cross Corporation
    Inventors: Kazumasa Yokoyama, Koichi Yamanouchi, Ryoichiro Murashima, Ryozo Watanabe