Patents by Inventor Ryoji Inaba

Ryoji Inaba has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9993822
    Abstract: When taking in outside air with a fan to control the temperature inside a covered portion where a specimen is installed, the internal temperature may change depending on an environment temperature to cause a difference in temperature control. The wind generated by the fan may blow against a reaction container depending on its loading position and it may influence the temperature control over individual specimens and lead to problems with temperature accuracy, temperature rise speed, and temperature drop speed. A reaction container avoiding these problems has a covered portion which performs temperature control on the reaction container and in which a cover and a fin cover have a heat insulating structure. A heat source is provided for controlling an internal temperature of an internal covered space. The internal temperature is kept constant and the influence of the environment temperature over the temperature control of the reaction container is minimized.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: June 12, 2018
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Kimikazu Sugiyama, Minoru Sano, Yasunori Shoji, Yoshiyuki Shoji, Yuki Kikuchi, Manami Nammoku, Ryoji Inaba
  • Patent number: 9970951
    Abstract: In the past, genetic testing systems for exclusive use were needed due to the difference in type or property of specimens. Therefore, a genetic testing system includes: an extraction unit; an assay preparation unit; a reading unit; a first conveying mechanism for conveying a sample among the extraction unit, the assay preparation unit, and the reading unit; multiple sample loading units which are provided corresponding to at least two units of the extraction unit, the assay preparation unit, and the reading unit; and multiple second conveying mechanisms which are provided corresponding to the multiple sample loading units and convey test samples to the inside of the system from the sample loading units.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: May 15, 2018
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Koshi Maeda, Hiroko Fujita, Yoshiyuki Shoji, Ryoji Inaba
  • Patent number: 9523124
    Abstract: Sample nucleic acids are prevented from removing from a sample-immobilizing layer during a sequencing reaction. A reaction device for nucleic acid analysis is provided that enables high throughput analysis by increasing the number of nucleic acid samples that can be analyzed. The reaction device for nucleic acid analysis comprises a substrate, a sample-immobilizing layer on the substrate, nucleic acid samples or carriers having nucleic acid samples on their surfaces, which are immobilized on the sample-immobilizing layer, and a blocking layer that covers areas other than areas where the nucleic acid samples or the carriers are bound to the sample-immobilizing layer, wherein the immobilizing layer is formed of an inorganic oxide.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: December 20, 2016
    Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Masatoshi Narahara, Taro Nakazawa, Ryoji Inaba
  • Patent number: 9393562
    Abstract: Provided is an analyzer capable of reducing the amount of wasted reagents and shortening time required for solution sending, thus increasing throughput for analysis. A microsyringe sucks a minimum required amount of reagent that is substantially the same amount of capacity of a flow cell to a sampling nozzle. Then, the sampling nozzle is inserted into an injection port of the flow cell, and the reagent is injected into the flow cell by driving the microsyringe. The inside of the sampling nozzle is cleaned by moving the sampling nozzle to the cleaning tank and ejecting cleaning water from the sampling nozzle, and the outside of the sampling nozzle is cleaned by spraying cleaning water from an inner wall of the cleaning tank.
    Type: Grant
    Filed: January 13, 2012
    Date of Patent: July 19, 2016
    Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Takuya Matsui, Ryoji Inaba, Kazumichi Imai, Ryusuke Kimura
  • Publication number: 20160144366
    Abstract: When taking in outside air with a fan to control the temperature inside a covered portion where a specimen is installed, the internal temperature may change depending on an environment temperature to cause a difference in temperature control. The wind generated by the fan may blow against a reaction container depending on its loading position and it may influence the temperature control over individual specimens and lead to problems with temperature accuracy, temperature rise speed, and temperature drop speed A reaction container avoiding these problems has a covered portion which performs temperature control on the reaction container and in which a cover and a fin cover have a heat insulating structure. A heat source is provided for controlling an internal temperature of an internal covered space. The internal temperature is kept constant and the influence of the environment temperature over the temperature control of the reaction container is minimized.
    Type: Application
    Filed: June 18, 2014
    Publication date: May 26, 2016
    Inventors: Kimikazu SUGIYAMA, Minoru SANO, Yasunori SHOJI, Yoshiyuki SHOJI, Yuki KIKUCHI, Manami NAMMOKU, Ryoji INABA
  • Patent number: 9207235
    Abstract: Provided is a reaction device for nucleic acid analysis wherein microparticles, which carry a nucleic acid to be detected having been immobilized thereon, are aligned in a lattice form on a substrate according to the pixel size of a two-dimensional sensor. By this reaction device for nucleic acid analysis which is provided with a channel-forming reaction chamber on the substrate (101), the nucleic acid having been immobilized on the microparticles (103) on the substrate (101) is detected. The microparticles (103), which carry the nucleic acid to be detected having been immobilized thereon, are arranged by microstructures (102) aligned on the substrate (101).
    Type: Grant
    Filed: December 1, 2010
    Date of Patent: December 8, 2015
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Yoshiaki Sugimura, Masatoshi Narahara, Kazumichi Imai, Toshiro Saito, Ryoji Inaba, Takuya Matsui
  • Publication number: 20150346228
    Abstract: In the past, genetic testing systems for exclusive use were needed due to the difference in type or property of specimens. Therefore, a genetic testing system includes: an extraction unit; an assay preparation unit; a reading unit; a first conveying mechanism for conveying a sample among the extraction unit, the assay preparation unit, and the reading unit; multiple sample loading units which are provided corresponding to at least two units of the extraction unit, the assay preparation unit, and the reading unit; and multiple second conveying mechanisms which are provided corresponding to the multiple sample loading units and convey test samples to the inside of the system from the sample loading units.
    Type: Application
    Filed: December 19, 2013
    Publication date: December 3, 2015
    Inventors: Koshi MAEDA, Hiroko FUJITA, Yoshiyuki SHOJI, Ryoji INABA
  • Patent number: 9150911
    Abstract: A nucleic acid analysis reaction cell and a nucleic acid analyzer are provided, in which a uniform flow rate is realized, so that a portion where a flow rate is low is removed and washing time for reagent removal is shortened. A flow path (103) is provided which includes a detection area (108) for detecting sequence information of a nucleic acid fragment and detection outer areas (107) disposed at both ends of the detection area (108). An inflow port (105) is provided in one of the detection outer areas (107) and a discharge port (106) is provided in the other of the detection outer areas (107). The detection outer areas (107) disposed at both the ends of the detection area (108) are areas whose widths become narrow toward ends, and guides (104) for branching a liquid are provided in at least the detection outer area (107) in which the inflow port (105) is provided.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: October 6, 2015
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Taro Nakazawa, Masatoshi Narahara, Ryoji Inaba, Yoshihiro Nagaoka, Shigenori Togashi
  • Patent number: 8906671
    Abstract: A chilled reagent container comprises a reagent vessel containing part for containing therein a plurality of reagent vessels, a container lid including a container lid hole through which the reagent vessels contained by the reagent vessel containing part are accessible, and a cooling block for cooling the reagent vessels contained by the reagent vessel containing part, wherein the container lid slides to be changeable between an opened situation wherein the reagent is accessible from an outside and a closed situation wherein the reagent is prevented from being accessed from the outside, wherein the chilled reagent container further comprises a reagent container packing including another hole through which the reagent vessels are accessible and arranged between the container lid and the reagent vessel containing part to be pressed against the container lid.
    Type: Grant
    Filed: June 25, 2012
    Date of Patent: December 9, 2014
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Motohiro Yamazaki, Ryoji Inaba, Shuhei Yamamoto, Takuya Matsui, Kohshi Maeda, Yuichiro Ota, Hiroyuki Higashino
  • Patent number: 8702949
    Abstract: The solution reservoir apparatus of the capillary electrophoresis apparatus securely affixes an evaporation-preventing membrane to a container when a capillary is inserted or withdrawn, without extending the cathode end of the capillary. The solution reservoir apparatus comprises a container for reserving a sample or solution, a cover having a bore through which the capillary is passed and covering the container, an evaporation-preventing membrane having a capillary hole through which the capillary is passed, and a container holder for holding the container. The evaporation-preventing membrane has a projection provided at the periphery of the capillary hole, the projection of the evaporation-preventing membrane is engaged with the bore on the cover when the evaporation-preventing membrane is positioned on the cover, and the evaporation-preventing membrane is supported by the cover.
    Type: Grant
    Filed: April 8, 2010
    Date of Patent: April 22, 2014
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Takeshi Ohura, Ryoji Inaba, Manabu Akiba, Takashi Gomi, Mari Kotoura
  • Patent number: 8685220
    Abstract: The invention provides a capillary electrophoresis apparatus which can improve the operability and measuring speed. According to the invention, a sensor for identifying the type of sample containers is fixed at the position away from a capillary anode electrode. The sensor is made to be closer to the sample containers by moving a moving stage so that the sample containers disposed on the moving stage can be identified by the sensor. A fixing apparatus for fixing at least a pair of sample containers is provided on the moving stage.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: April 1, 2014
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Takeshi Ohura, Ryoji Inaba, Yoshitaka Kodama, Hiromi Yamashita, Manabu Akiba, Tomohiro Shoji
  • Publication number: 20130316336
    Abstract: Provided is an analyzer capable of reducing the amount of wasted reagents and shortening time required for solution sending, thus increasing throughput for analysis. A microsyringe sucks a minimum required amount of reagent that is substantially the same amount of capacity of a flow cell to a sampling nozzle. Then, the sampling nozzle is inserted into an injection port of the flow cell, and the reagent is injected into the flow cell by driving the microsyringe. The inside of the sampling nozzle is cleaned by moving the sampling nozzle to the cleaning tank and ejecting cleaning water from the sampling nozzle, and the outside of the sampling nozzle is cleaned by spraying cleaning water from an inner wall of the cleaning tank.
    Type: Application
    Filed: January 13, 2012
    Publication date: November 28, 2013
    Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Takuya Matsui, Ryoji Inaba, Kazumichi Imai, Ryusuke Kimura
  • Publication number: 20130296197
    Abstract: Sample nucleic acids are prevented from removing from a sample-immobilizing layer during a sequencing reaction. A reaction device for nucleic acid analysis is provided that enables high throughput analysis by increasing the number of nucleic acid samples that can be analyzed. The reaction device for nucleic acid analysis comprises a substrate, a sample-immobilizing layer on the substrate, nucleic acid samples or carriers having nucleic acid samples on their surfaces, which are immobilized on the sample-immobilizing layer, and a blocking layer that covers areas other than areas where the nucleic acid samples or the carriers are bound to the sample-immobilizing layer, wherein the immobilizing layer is formed of an inorganic oxide.
    Type: Application
    Filed: December 13, 2011
    Publication date: November 7, 2013
    Inventors: Masatoshi Narahara, Taro Nakazawa, Ryoji Inaba
  • Patent number: 8545686
    Abstract: The present invention relates to detection of an emission spectrum by irradiating excitation light onto a plurality of electrophoretic paths and dispersing fluorescent light output from the electrophoretic paths in a direction approximately vertical to an electrophoretic direction. According to the invention, since an emission spectrum to be detected does not substantially change over time, it becomes possible to make observed emission spectrums completely correspond to various fluorescent dyes or various bases.
    Type: Grant
    Filed: April 5, 2006
    Date of Patent: October 1, 2013
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Ryoji Inaba, Tomoyuki Sakai, Motohiro Yamazaki, Takashi Gomi, Kazumichi Imai
  • Patent number: 8454812
    Abstract: A capillary electrophoresis apparatus capable of efficiently using a polymer in a polymer container is provided. The present invention relates to a mechanism for efficiently using the polymer in the polymer container in a capillary electrophoresis apparatus for the electrophoresis with a separation medium filled in a capillary. According to the present invention, since the polymer in the polymer container is not contacted with the air, deterioration of the polymer by oxidation can be prevented.
    Type: Grant
    Filed: June 26, 2007
    Date of Patent: June 4, 2013
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Miho Ozawa, Ryoji Inaba
  • Publication number: 20130084629
    Abstract: A nucleic acid analysis reaction cell and a nucleic acid analyzer are provided, in which a uniform flow rate is realised, so that a portion where a flow rate is low is removed and washing time for reagent removal is shortened. A flow path (103) is provided which includes a detection area (108) for detecting sequence information of a nucleic acid fragment and detection outer areas (107) disposed at both ends of the detection area (108). An inflow port (105) is provided in one of the detection outer areas (107) and a discharge port (106) is provided in the other of the detection outer areas (107). The detection outer areas (107) disposed at both the ends of the detection area (108) are areas whose widths become narrow toward ends, and guides (104) for branching a liquid are provided in at least the detection outer area (107) in which the inflow port (105) is provided.
    Type: Application
    Filed: April 20, 2011
    Publication date: April 4, 2013
    Applicant: Hitachi High-Technologies Corporation
    Inventors: Taro Nakazawa, Masatoshi Narahara, Ryoji Inaba, Yoshihiro Nagaoka, Shigenori Togashi
  • Patent number: 8366896
    Abstract: Provided is a capillary electrophoresis device including a holder preventing a septum from coming off when a capillary is pulled out, and also allowing containers to be taken out in any order. In the capillary electrophoresis device for separating and analyzing a sample such as a DNA and a protein by electrophoresis, the holder includes: a septum having a capillary hole through which a capillary penetrates; a container for storing a solution; and a container-accommodation unit for accommodating the container. A hole formed in the septum engages with an engagement portion formed on the container, and thereby the septum is held to cover the container.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: February 5, 2013
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Takeshi Ooura, Ryoji Inaba
  • Patent number: 8349161
    Abstract: Bubbles can be removed regardless of an individual difference of a pump to fill an electrophoresis medium into a capillary. Of flow passages formed between an inner side surface of a container for accommodating the electrophoresis medium and a side surface of a plunger, one of the flow passages causing an electrophoresis medium to be easily stagnant is formed to have the cross-sectional area larger than the cross-sectional area of the other flow passage on the opposite side. In other words, the flow passage portion causing the electrophoresis medium to be easily stagnant is formed in such a manner as to increase a flow amount of the electrophoresis medium. This can eliminate a region having an extremely small amount of electrophoresis medium flow in the pump.
    Type: Grant
    Filed: April 6, 2010
    Date of Patent: January 8, 2013
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Takashi Gomi, Ryoji Inaba, Taro Nakazawa, Takeshi Ohura, Mari Kotoura
  • Patent number: D679832
    Type: Grant
    Filed: May 28, 2009
    Date of Patent: April 9, 2013
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Mitsuru Oonuma, Tomohiro Shoji, Ryoji Inaba
  • Patent number: D681233
    Type: Grant
    Filed: April 22, 2011
    Date of Patent: April 30, 2013
    Assignee: Life Technologies Corporation
    Inventors: Richard Thomas, Laurence Trigg, Mitsuru Oonuma, Jin Matsumura, Ryoji Inaba