Abstract: A highly safe and useful therapeutic agent for hypoalbuminaemia contains a hydantoin derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof as an effective ingredient: 1

Abstract: A highly safe and useful therapeutic agent for hypoalbuminaemia contains a hydantoin derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof as an effective ingredient: wherein each of R1 and R2, which may be the same or different, represents hydrogen, an alkyl group or a cycloalkyl group; and each of X and Y, which may be the same or different, represents hydrogen, a hydroxyl group, an alkyl group or an alkoxy group, or X and Y together represent an oxo group. Administration of the compounds substantially increases the serum albumin value of patients suffering from hypoalbuminaemia from abnormal values, and significantly improves the condition of hypoalbuminaemia.

Abstract: The present invention relates to a method of preparing bronchial hypersensitive or hyposensitive guinea pigs by selective breeding on the basis of bronchial sensitivity to inhalant chemicals inducing bronchoconstriction. The hypersensitive guinea pigs of the present invention are extremely useful as model animals for the study of bronchial asthma and allergic rhinitis and for the evaluation of efficacy of-antiasthmatics and antiallergic substances.