Patents by Inventor Ryoki Orii

Ryoki Orii has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR PRODUCING DI(ARYLAMINO)ARYL COMPOUND AND SYNTHETIC INTERMEDIATE THEREFOR
    Publication number: 20130338358
    Abstract: Provided is a method for producing a di(arylamino)aryl compound that has superior inhibitory activity against the kinase activities of EML4-ALK fusion protein and mutant EGFR protein and is useful as an active ingredient in pharmaceutical compositions for cancer treatment. The production method includes no purification step using silica gel column chromatography or no step possibly producing a mutagenic mesylate ester as a by-product, greatly improves overall yield, and is high yield and low cost and suitable for the industrial production of pharmaceutical products. Also provided is a synthetic intermediate that is useful in the production method.
    Type: Application
    Filed: January 27, 2012
    Publication date: December 19, 2013
    Applicant: Astellas Pharma Inc.
    Inventors: Kazuyoshi Obitsu, Takahiro Akiba, Koji Kobayashi, Shun Hirasawa, Yutaka Kondoh, Kazuhiro Takeguchi, Vuji Takahama, Ryoki Orii
  • Process for the preparation of a piperazine derivative
    Patent number: 7229992
    Abstract: (2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-4-[2-[(2S)-2-(methoxymethyl)morpholino]ethyl]-2-(3-hydroxy-4-methylbenzyl)piperazine dihydrochloride is obtained by debenzylating (2R)-4-benzyl-1-[3,5-bis(trifluoromethyl)-benzoyl]-2-(3-hydroxy-4-methylbenzyl)piperazine, then N-alkylating and converting to hydrochloride.
    Type: Grant
    Filed: June 8, 2001
    Date of Patent: June 12, 2007
    Assignee: Astellas Pharma Inc.
    Inventors: Keiichi Koga, Ryoki Orii, Yosuke Fujii, Shunsuke Goto, Satoshi Hirabayashi
  • Process for the preparation of a piperazine derivative
    Publication number: 20030153753
    Abstract: (2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-4-[2-[(2S)-2-(methoxymethyl)morpholino]ethyl]-2-(3-hydroxy-4-methylbenzyl)piperazine dihydrochloride is obtained by debenzylating (2R)-4-benzyl-1-[3,5-bis(trifluoromethyl)-benzoyl]-2-(3-hydroxy-4-methylbenzyl)piperazine, then N-alkylating and converting to hydrochloride.
    Type: Application
    Filed: December 13, 2002
    Publication date: August 14, 2003
    Inventors: Keiichi Koga, Ryoki Orii, Yosuke Fujii, Shunsuke Goto, Satoshi Hirabayashi
  • New processes for producing beta-alanine derivatives
    Publication number: 20030114488
    Abstract: The present invention relates to processes for the preparation of &bgr;-alanine derivative shown by following formula (I): 1
    Type: Application
    Filed: December 13, 2002
    Publication date: June 19, 2003
    Applicant: Fujisawa Pharmaceutical Co. Ltd.
    Inventors: Mitsuru Ohkubo, Satoru Kuroda, Hideko Nakamura, Hisashi Takasugi, Yosuke Fujii, Keiichi Koga, Eiki Oikawa, Ryoki Orii, Shunsuke Goto
  • N-[(R)-1-[3-(4-piperidyl)propionyl]-3-piperidylcarbonyl]-2(S)-acetylamino-&bgr;-alanine trihydrate, compositions thereof, and methods for its use
    Patent number: 6538007
    Abstract: The trihydrates of &bgr;-alanine of the formula Are disclosed. Also method of antogonizing glycoprotein IIb/IIIa activity using these compounds is also disclosed.
    Type: Grant
    Filed: April 12, 2001
    Date of Patent: March 25, 2003
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Mitsuru Ohkubo, Satoru Kuroda, Hideko Nakamura, Hisashi Takasugi, Yosuke Fujii, Keiichi Koga, Eiki Oikawa, Ryoki Orii, Shunsuke Goto