Patents by Inventor Ryosuke Gonotsubo

Ryosuke Gonotsubo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240052309
    Abstract: [Problems] To provide a method for producing regenerated T cells via iPS cells into which TCRs isolated from tumor tissue-infiltrating CD106-positive T cells have been introduced. [Solutions] Provided is a method for producing regenerated T cells via iPS cells, comprising: 1. A step for preparing cDNAs respectively encoding a TCR ? chain and a TCR ? chain from individual cells in a CD106-positive T cell population obtained from subjects and having reactivity with a tumor-related antigen; 2. A step for reprogramming peripheral blood mononuclear cells which are obtained from the subjects and from which B cells and T cells have been removed or T cells into iPS cells, and selecting iPS cell clones having high efficiency of differentiation into T cells from the obtained iPS cells; 3.
    Type: Application
    Filed: December 29, 2021
    Publication date: February 15, 2024
    Inventors: Shin Kaneko, Ryosuke Gonotsubo, Mitsujiro Osawa, Yasumichi Hitoshi, Kazuo Yamashita, Nicolas Claude Paul Sax