Abstract: The present invention provides a particle manufacturing device and a manufacturing method for frozen particles capable of quickly manufacturing frozen particles while preventing clogging of a nozzle due to freezing. The present invention provides a particle manufacturing device including: a freezing chamber in which frozen particles obtained by freezing an object to be treated containing moisture in a particulate form are accommodated; an ultrasonic nozzle configured to discharge the object to be treated after or before being frozen in a particulate form into the freezing chamber; and a decompression device configured to decompress the freezing chamber, in which the moisture is evaporated due to decompression, and the frozen particles are cooled and frozen by the evaporation of the moisture.

Abstract: A process for preparing a compound of formula (I) or a salt or solvate thereof, by reacting a compound of formula (IV): with a compound of formula (V): to obtain the compound of formula (I): wherein each R1 is independently a halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 haloalkoxy or C1-C6 alkylcarbonyl; R2 is C1-C6 alkyl, C1-C6 haloalkyl, or phenyl optionally substituted with at least one selected from the group consisting of a halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 haloalkoxy, and nitro; R3 is C1-C6 alkyl, C3-C8 cycloalkyl, or a phenyl optionally substituted at least one selected from the group consisting of a halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, and C1-C6 haloalkoxy; n is 0, 1, or 2; and X is S atom or O atom.