Abstract: This disclosure relates to the production and use of an isolated, purified and/or recombinant T cell receptor (TCR) that specifically binds to a mutant IDH1 protein, or a fragment thereof, wherein the mutant IDH1 protein or fragment thereof comprises an R132H mutation.

Abstract: An oil ring mechanism of a piston includes a circumferential ring groove formed in an outer peripheral surface of the piston, and a two-piece oil ring having a ring-shaped ring main body that is arranged in the ring groove and urged in the outer peripheral direction inside the ring groove by a coil expander arranged on the inner peripheral side of the oil ring main body. On lower side surface on a crankcase side of a side wall surface of the ring groove that is on the opposite side of the ring groove from an engine combustion chamber, first and second recessed portions that reduce the abutment area where a lower surface of the ring main body abuts against the lower side surface formed in a lower side abutment surface that serves as a surface for abutting against the lower surface of the ring main body.