Abstract: A working tool and a drilling method capable of improving workability are provided. A working tool includes a motor, a trigger switch to instruct the driving of the motor, and a microcontroller to control the driving of the motor. The microcontroller stops the motor without transitioning to a retry mode when detecting a rapid increase of a motor current. The microcontroller transitions to the retry mode when detecting an overload without accompanying the rapid increase of the motor current. In the retry mode, the activation and stop of the motor are repeated. When the load applied to a tool bit is eliminated during execution of the retry mode, the microcontroller returns to a normal mode while the trigger switch is kept on.

Abstract: A power tool includes a prime mover, an output shaft that extends along a first direction and retains a tip tool and is driven by the prime mover, a support member that supports the output shaft to be drivable, a gear that rotates around an axis extending in a second direction crossing the first direction and transmits a power of the prime mover to the output shaft, and a gear cover that accommodates the gear and the support member. Inside the gear cover, a lubricant retention portion capable of retaining a lubricant is arranged at a side of the support member, and the lubricant retention portion is partitioned from a gear accommodation portion that accommodates a gear by a wall extending in a direction intersecting an extending direction of the output shaft in the gear cover.

Abstract: An object of the present invention is to provide a bispecific antibody having an agonist activity to a GM-CSF receptor, and a bispecific antibody fragment thereof. The present invention relates to a bispecific antibody or a bispecific antibody fragment thereof containing: a first antigen-binding domain; and a second antigen-binding domain, in which one of the first antigen-binding domain and the second antigen-binding domain is an antigen-binding domain binding to CD116, and the other one is an antigen-binding domain binding to CD131.

Abstract: The invention relates to an antibody which binds to chondroitin sulfate proteoglycan 5 (CSPG5) or an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment thereof, a nucleic acid comprising a nucleotide sequence encoding the antibody or the antibody fragment thereof, a transformant cell comprising a vector comprising the nucleic acid, a method for producing the antibody or the antibody fragment thereof, a composition comprising the antibody or the antibody fragment thereof, and a method for detecting or measuring an antigen present in the brain, a method for diagnosing or treating a brain disease, a method for enhancing the property of accumulating in a brain of an antibody, and a method for increasing the amount of an antibody in the brain, each of which using the antibody or the antibody fragment thereof, and the like.

Abstract: The invention relates to an antibody which binds to myelin oligodendrocyte glycoprotein (MOG), an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment, a nucleic acid containing a nucleotide sequence which encodes the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment, a composition containing the antibody or the antibody fragment and a method for detecting or measuring an antigen that is present in the brain, a method for diagnosing or treating a brain disease, a method for improving the property of an antibody of accumulating in the brain and a method for increasing the amount of an antibody in the brain which use the antibody or the antibody fragment.

Abstract: A powered tool includes a housing, a drive source, a drive body, a sealing part, and a holding part. The drive source is rotatable in the housing. The drive body is supported in the housing and reciprocatable by a driving force of the drive source. The sealing part is in contact with an outer peripheral surface of the drive body. The holding part is positioned around the drive body. The holding part surrounds the sealing part and supports the sealing part to be in contact with the outer peripheral surface of the drive body. The holding part includes a lubrication oil accommodating part retaining a lubricant supplied to the outer peripheral surface of the drive body.

Abstract: The invention relates to an antibody which binds to cell adhesion molecule 3 (CADM3) or an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment thereof, a nucleic acid comprising a nucleotide sequence encoding the antibody or the antibody fragment thereof, a transformant cell comprising a vector comprising the nucleic acid, a method for producing the antibody or the antibody fragment thereof, a composition comprising the antibody or the antibody fragment thereof, and a method for detecting or measuring an antigen present in the brain, a method for diagnosing or treating a brain disease, a method for enhancing the property of accumulating in a brain of an antibody, and a method for increasing the amount of an antibody in the brain, each of which using the antibody or the antibody fragment thereof, and the like.

Abstract: Provided is a work machine. The work machine has a brushless motor, and the brushless motor has a plurality of teeth. A stator coil is wound around each of the teeth. An end portion of each stator coil is connected to a circuit board. The circuit board has: a first conductor pattern connecting the stator coils wound around adjacent teeth; and a second conductor pattern and a third conductor pattern each connecting the stator coils wound around the non-adjacent teeth. The plurality of stator coils are in the form of delta connection parallel winding.

Abstract: There is provided a power tool in which impact applied to a power transmission portion can be mitigated to thereby suppress components constituting the power transmission portion from being deformed and damaged. The power tool includes a brushless motor 3 having a rotation shaft portion 31 rotatable about a rotation axis A1, a housing 2 accommodating therein the brushless motor 3, a power transmission portion 6 configured to receive a rotation force of the rotation shaft portion 31 and to transmit a driving force based on the rotation force, and a driven portion 7 configured to be driven by receiving the transmitted driving force. The rotation shaft portion 31 is supported by the housing 2 so as to be movable relative to the housing 2 in an axial direction of the rotation axis A1.

Abstract: Providing a reciprocating tool capable of reducing vibrations generated during operations and improving work performance and processing precision. A reciprocating tool includes a transmission gear part 61 and a counter weight part 62. The transmission gear part 61 includes a bevel gear 611 and a weight 611A. The bevel gear 611 is rotatable in a first direction about an axis B by receiving a drive force of a motor 3. The weight 62A is rotatable in a second direction opposite to the first direction about the axis B by receiving the drive force of the motor 3. A center of gravity 61G of the transmission gear part 61 and a center of gravity 62G of the counter weight part 62 are separated farthest from a blade mounting part 8 when the blade mounting part 8 is positioned in a rearward position.

Abstract: An objective is to provide an Fc-modified antibody or the like having a long serum half-life according to a CCAP method, more specifically, an antibody or the like where IgBP is bound to only one site, based on findings of the inventors. Provided is an objective antibody or the like by purification and production of an Fc-modified antibody or the like with a column bound to an Fc region of an antibody. Specifically, an antibody where only one of two binding sites of Fc is selectively modified is provided by allowing an IgBP-bound antibody produced by a CCAP method to adsorb to a carrier of an IgBP-immobilized column, or forming a state where only one Fc of an antibody is bound to an IgBP binding column and then adding a peptide reagent for CCAP to the column to perform a reaction of a CCAP method in the column.

Abstract: A front grease retention unit is provided under a front plunger and a wall is provided between the retention unit and a gear accommodation unit. Furthermore, a front grease receiving member is provided under the front plunger and a front metal bearing, and grease falling into the front grease receiving member is sent toward the outer circumferential face of the front plunger. The grease is pushed out by using the vertical oscillation of a front metal anchor bolt in orbital mode. A rear grease receiving member is provided under a rear plunger and a rear metal bearing, and grease falling into the rear grease receiving member is sent toward the outer circumferential face of the rear plunger. The grease in a grease reservoir groove is pushed out by using the vertical oscillation of a rear metal anchor bolt in orbital mode.

Abstract: The invention relates to an antibody which binds to myelin oligodendrocyte glycoprotein (MOG), an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment, a nucleic acid containing a nucleotide sequence which encodes the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment, a composition containing the antibody or the antibody fragment and a method for detecting or measuring an antigen that is present in the brain, a method for diagnosing or treating a brain disease, a method for improving the property of an antibody of accumulating in the brain and a method for increasing the amount of an antibody in the brain which use the antibody or the antibody fragment.

Abstract: The present invention relates to a bispecific antibody in which an N-terminal side polypeptide is bound to an IgG portion that binds to TfR, a bispecific antibody fragment thereof, a DNA encoding the bispecific antibody or the bispecific antibody fragment thereof, a vector containing the DNA, a hybridoma and a transformant that produce the bispecific antibody or the bispecific antibody fragment thereof, a method for producing the bispecific antibody or the bispecific antibody fragment thereof, therapeutic and diagnostic agents containing the bispecific antibody or the bispecific antibody fragment thereof, therapeutic and diagnostic methods using the bispecific antibody or the bispecific antibody fragment thereof, and a reagent for detection or measurement containing the bispecific antibody or the bispecific antibody fragment thereof.

Abstract: The invention relates to an antibody which binds to myelin oligodendrocyte glycoprotein (MOG), an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment, a nucleic acid containing a nucleotide sequence which encodes the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment, a composition containing the antibody or the antibody fragment and a method for detecting or measuring an antigen that is present in the brain, a method for diagnosing or treating a brain disease, a method for improving the property of an antibody of accumulating in the brain and a method for increasing the amount of an antibody in the brain which use the antibody or the antibody fragment.

Abstract: The invention relates to an antibody which binds to chondroitin sulfate proteoglycan 5 (CSPG5) or an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment thereof, a nucleic acid comprising a nucleotide sequence encoding the antibody or the antibody fragment thereof, a transformant cell comprising a vector comprising the nucleic acid, a method for producing the antibody or the antibody fragment thereof, a composition comprising the antibody or the antibody fragment thereof, and a method for detecting or measuring an antigen present in the brain, a method for diagnosing or treating a brain disease, a method for enhancing the property of accumulating in a brain of an antibody, and a method for increasing the amount of an antibody in the brain, each of which using the antibody or the antibody fragment thereof, and the like.

Abstract: A powered tool includes a housing, a drive source, a drive body, a sealing part, and a holding part. The drive source is rotatable in the housing. The drive body is supported in the housing and reciprocatable by a driving force of the drive source. The sealing part is in contact with an outer peripheral surface of the drive body. The holding part is positioned around the drive body. The holding part surrounds the sealing part and supports the sealing part to be in contact with the outer peripheral surface of the drive body. The holding part includes a lubrication oil accommodating part retaining a lubricant supplied to the outer peripheral surface of the drive body.

Abstract: There is provided a power tool in which impact applied to a power transmission portion can be mitigated to thereby suppress components constituting the power transmission portion from being deformed and damaged. The power tool includes a brushless motor 3 having a rotation shaft portion 31 rotatable about a rotation axis A1, a housing 2 accommodating therein the brushless motor 3, a power transmission portion 6 configured to receive a rotation force of the rotation shaft portion 31 and to transmit a driving force based on the rotation force, and a driven portion 7 configured to be driven by receiving the transmitted driving force. The rotation shaft portion 31 is supported by the housing 2 so as to be movable relative to the housing 2 in an axial direction of the rotation axis A1.

Abstract: The invention relates to an antibody which binds to cell adhesion molecule 3 (CADM3) or an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment thereof, a nucleic acid comprising a nucleotide sequence encoding the antibody or the antibody fragment thereof, a transformant cell comprising a vector comprising the nucleic acid, a method for producing the antibody or the antibody fragment thereof, a composition comprising the antibody or the antibody fragment thereof, and a method for detecting or measuring an antigen present in the brain, a method for diagnosing or treating a brain disease, a method for enhancing the property of accumulating in a brain of an antibody, and a method for increasing the amount of an antibody in the brain, each of which using the antibody or the antibody fragment thereof, and the like.

Abstract: Providing a reciprocating tool capable of reducing vibrations generated during operations and improving work performance and processing precision. A reciprocating tool includes a transmission gear part 61 and a counter weight part 62. The transmission gear part 61 includes a bevel gear 611 and a weight 611A. The bevel gear 611 is rotatable in a first direction about an axis B by receiving a drive force of a motor 3. The weight 62A is rotatable in a second direction opposite to the first direction about the axis B by receiving the drive force of the motor 3. A center of gravity 61G of the transmission gear part 61 and a center of gravity 62G of the counter weight part 62 are separated farthest from a blade mounting part 8 when the blade mounting part 8 is positioned in a rearward position.