Patents by Inventor Ryosuke Nakano

Ryosuke Nakano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11873337
    Abstract: The invention relates to an antibody which binds to cell adhesion molecule 3 (CADM3) or an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment thereof, a nucleic acid comprising a nucleotide sequence encoding the antibody or the antibody fragment thereof, a transformant cell comprising a vector comprising the nucleic acid, a method for producing the antibody or the antibody fragment thereof, a composition comprising the antibody or the antibody fragment thereof, and a method for detecting or measuring an antigen present in the brain, a method for diagnosing or treating a brain disease, a method for enhancing the property of accumulating in a brain of an antibody, and a method for increasing the amount of an antibody in the brain, each of which using the antibody or the antibody fragment thereof, and the like.
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: January 16, 2024
    Assignees: KYOWA KIRIN CO., LTD., KAGOSHIMA UNIVERSITY
    Inventors: Nobuaki Takahashi, Ryosuke Nakano, Sayaka Maeda, Takenao Yamada, Yuji Ito
  • Publication number: 20230402899
    Abstract: Provided is a work machine. The work machine has a brushless motor, and the brushless motor has a plurality of teeth. A stator coil is wound around each of the teeth. An end portion of each stator coil is connected to a circuit board. The circuit board has: a first conductor pattern connecting the stator coils wound around adjacent teeth; and a second conductor pattern and a third conductor pattern each connecting the stator coils wound around the non-adjacent teeth. The plurality of stator coils are in the form of delta connection parallel winding.
    Type: Application
    Filed: October 22, 2021
    Publication date: December 14, 2023
    Applicant: Koki Holdings Co., Ltd.
    Inventors: Ken INUI, Ryosuke NAKANO, Chisho SO, Satoru GUNJI
  • Patent number: 11780071
    Abstract: There is provided a power tool in which impact applied to a power transmission portion can be mitigated to thereby suppress components constituting the power transmission portion from being deformed and damaged. The power tool includes a brushless motor 3 having a rotation shaft portion 31 rotatable about a rotation axis A1, a housing 2 accommodating therein the brushless motor 3, a power transmission portion 6 configured to receive a rotation force of the rotation shaft portion 31 and to transmit a driving force based on the rotation force, and a driven portion 7 configured to be driven by receiving the transmitted driving force. The rotation shaft portion 31 is supported by the housing 2 so as to be movable relative to the housing 2 in an axial direction of the rotation axis A1.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: October 10, 2023
    Assignee: KOKI HOLDINGS CO., LTD.
    Inventors: Yasutaka Shimizu, Yoshikazu Yokoyama, Naoki Tadokoro, Ryosuke Nakano
  • Patent number: 11701722
    Abstract: Providing a reciprocating tool capable of reducing vibrations generated during operations and improving work performance and processing precision. A reciprocating tool includes a transmission gear part 61 and a counter weight part 62. The transmission gear part 61 includes a bevel gear 611 and a weight 611A. The bevel gear 611 is rotatable in a first direction about an axis B by receiving a drive force of a motor 3. The weight 62A is rotatable in a second direction opposite to the first direction about the axis B by receiving the drive force of the motor 3. A center of gravity 61G of the transmission gear part 61 and a center of gravity 62G of the counter weight part 62 are separated farthest from a blade mounting part 8 when the blade mounting part 8 is positioned in a rearward position.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: July 18, 2023
    Assignee: KOKI HOLDINGS CO., LTD.
    Inventors: Tetsuya Monzen, Ryosuke Nakano
  • Publication number: 20220363716
    Abstract: An objective is to provide an Fc-modified antibody or the like having a long serum half-life according to a CCAP method, more specifically, an antibody or the like where IgBP is bound to only one site, based on findings of the inventors. Provided is an objective antibody or the like by purification and production of an Fc-modified antibody or the like with a column bound to an Fc region of an antibody. Specifically, an antibody where only one of two binding sites of Fc is selectively modified is provided by allowing an IgBP-bound antibody produced by a CCAP method to adsorb to a carrier of an IgBP-immobilized column, or forming a state where only one Fc of an antibody is bound to an IgBP binding column and then adding a peptide reagent for CCAP to the column to perform a reaction of a CCAP method in the column.
    Type: Application
    Filed: October 23, 2020
    Publication date: November 17, 2022
    Inventors: Yuji Ito, Nobuaki Takahashi, Ryosuke Nakano, Sayaka Maeda
  • Publication number: 20220072638
    Abstract: A front grease retention unit is provided under a front plunger and a wall is provided between the retention unit and a gear accommodation unit. Furthermore, a front grease receiving member is provided under the front plunger and a front metal bearing, and grease falling into the front grease receiving member is sent toward the outer circumferential face of the front plunger. The grease is pushed out by using the vertical oscillation of a front metal anchor bolt in orbital mode. A rear grease receiving member is provided under a rear plunger and a rear metal bearing, and grease falling into the rear grease receiving member is sent toward the outer circumferential face of the rear plunger. The grease in a grease reservoir groove is pushed out by using the vertical oscillation of a rear metal anchor bolt in orbital mode.
    Type: Application
    Filed: November 29, 2019
    Publication date: March 10, 2022
    Applicant: Koki Holdings Co., Ltd.
    Inventors: Ryosuke NAKANO, Yoshikazu YOKOYAMA, Ken INUI
  • Publication number: 20220025044
    Abstract: The invention relates to an antibody which binds to myelin oligodendrocyte glycoprotein (MOG), an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment, a nucleic acid containing a nucleotide sequence which encodes the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment, a composition containing the antibody or the antibody fragment and a method for detecting or measuring an antigen that is present in the brain, a method for diagnosing or treating a brain disease, a method for improving the property of an antibody of accumulating in the brain and a method for increasing the amount of an antibody in the brain which use the antibody or the antibody fragment.
    Type: Application
    Filed: August 11, 2021
    Publication date: January 27, 2022
    Applicants: Kyowa Kirin Co., Ltd., KAGOSHIMA UNIVERSITY
    Inventors: Nobuaki TAKAHASHI, Ryosuke NAKANO, Sayaka MAEDA, Yuji ITO
  • Publication number: 20220017635
    Abstract: The present invention relates to a bispecific antibody in which an N-terminal side polypeptide is bound to an IgG portion that binds to TfR, a bispecific antibody fragment thereof, a DNA encoding the bispecific antibody or the bispecific antibody fragment thereof, a vector containing the DNA, a hybridoma and a transformant that produce the bispecific antibody or the bispecific antibody fragment thereof, a method for producing the bispecific antibody or the bispecific antibody fragment thereof, therapeutic and diagnostic agents containing the bispecific antibody or the bispecific antibody fragment thereof, therapeutic and diagnostic methods using the bispecific antibody or the bispecific antibody fragment thereof, and a reagent for detection or measurement containing the bispecific antibody or the bispecific antibody fragment thereof.
    Type: Application
    Filed: December 27, 2019
    Publication date: January 20, 2022
    Applicant: Kyowa Kirin Co., Ltd.
    Inventors: Keisuke MITAMURA, Ryosuke NAKANO, Masayuki KAI, Nobuaki TAKAHASHI
  • Patent number: 11117963
    Abstract: The invention relates to an antibody which binds to myelin oligodendrocyte glycoprotein (MOG), an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment, a nucleic acid containing a nucleotide sequence which encodes the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment, a composition containing the antibody or the antibody fragment and a method for detecting or measuring an antigen that is present in the brain, a method for diagnosing or treating a brain disease, a method for improving the property of an antibody of accumulating in the brain and a method for increasing the amount of an antibody in the brain which use the antibody or the antibody fragment.
    Type: Grant
    Filed: December 25, 2017
    Date of Patent: September 14, 2021
    Assignees: KYOWA HAKKO KIRIN CO., LTD., KAGOSHIMA UNIVERSITY
    Inventors: Nobuaki Takahashi, Ryosuke Nakano, Sayaka Maeda, Yuji Ito
  • Publication number: 20210269548
    Abstract: The invention relates to an antibody which binds to chondroitin sulfate proteoglycan 5 (CSPG5) or an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment thereof, a nucleic acid comprising a nucleotide sequence encoding the antibody or the antibody fragment thereof, a transformant cell comprising a vector comprising the nucleic acid, a method for producing the antibody or the antibody fragment thereof, a composition comprising the antibody or the antibody fragment thereof, and a method for detecting or measuring an antigen present in the brain, a method for diagnosing or treating a brain disease, a method for enhancing the property of accumulating in a brain of an antibody, and a method for increasing the amount of an antibody in the brain, each of which using the antibody or the antibody fragment thereof, and the like.
    Type: Application
    Filed: June 26, 2019
    Publication date: September 2, 2021
    Applicants: Kyowa Kirin Co., Ltd., KAGOSHIMA UNIVERSITY
    Inventors: Nobuaki TAKAHASHI, Ryosuke NAKANO, Sayaka MAEDA, Yuji ITO
  • Publication number: 20210252657
    Abstract: A powered tool includes a housing, a drive source, a drive body, a sealing part, and a holding part. The drive source is rotatable in the housing. The drive body is supported in the housing and reciprocatable by a driving force of the drive source. The sealing part is in contact with an outer peripheral surface of the drive body. The holding part is positioned around the drive body. The holding part surrounds the sealing part and supports the sealing part to be in contact with the outer peripheral surface of the drive body. The holding part includes a lubrication oil accommodating part retaining a lubricant supplied to the outer peripheral surface of the drive body.
    Type: Application
    Filed: April 12, 2019
    Publication date: August 19, 2021
    Applicant: KOKI HOLDINGS CO., LTD.
    Inventors: Ryosuke NAKANO, Yoshikazu YOKOYAMA
  • Publication number: 20210187722
    Abstract: There is provided a power tool in which impact applied to a power transmission portion can be mitigated to thereby suppress components constituting the power transmission portion from being deformed and damaged. The power tool includes a brushless motor 3 having a rotation shaft portion 31 rotatable about a rotation axis A1, a housing 2 accommodating therein the brushless motor 3, a power transmission portion 6 configured to receive a rotation force of the rotation shaft portion 31 and to transmit a driving force based on the rotation force, and a driven portion 7 configured to be driven by receiving the transmitted driving force. The rotation shaft portion 31 is supported by the housing 2 so as to be movable relative to the housing 2 in an axial direction of the rotation axis A1.
    Type: Application
    Filed: November 30, 2018
    Publication date: June 24, 2021
    Applicant: KOKI HOLDINGS CO., LTD.
    Inventors: Yasutaka SHIMIZU, Yoshikazu YOKOYAMA, Naoki TADOKORO, Ryosuke NAKANO
  • Publication number: 20210147541
    Abstract: The invention relates to an antibody which binds to cell adhesion molecule 3 (CADM3) or an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment thereof, a nucleic acid comprising a nucleotide sequence encoding the antibody or the antibody fragment thereof, a transformant cell comprising a vector comprising the nucleic acid, a method for producing the antibody or the antibody fragment thereof, a composition comprising the antibody or the antibody fragment thereof, and a method for detecting or measuring an antigen present in the brain, a method for diagnosing or treating a brain disease, a method for enhancing the property of accumulating in a brain of an antibody, and a method for increasing the amount of an antibody in the brain, each of which using the antibody or the antibody fragment thereof, and the like.
    Type: Application
    Filed: June 26, 2019
    Publication date: May 20, 2021
    Applicants: Kyowa Kirin Co., Ltd., KAGOSHIMA UNIVERSITY
    Inventors: Nobuaki TAKAHASHI, Ryosuke NAKANO, Sayaka MAEDA, Takenao YAMADA, Yuji ITO
  • Publication number: 20200094432
    Abstract: Providing a reciprocating tool capable of reducing vibrations generated during operations and improving work performance and processing precision. A reciprocating tool includes a transmission gear part 61 and a counter weight part 62. The transmission gear part 61 includes a bevel gear 611 and a weight 611A. The bevel gear 611 is rotatable in a first direction about an axis B by receiving a drive force of a motor 3. The weight 62A is rotatable in a second direction opposite to the first direction about the axis B by receiving the drive force of the motor 3. A center of gravity 61G of the transmission gear part 61 and a center of gravity 62G of the counter weight part 62 are separated farthest from a blade mounting part 8 when the blade mounting part 8 is positioned in a rearward position.
    Type: Application
    Filed: April 27, 2018
    Publication date: March 26, 2020
    Applicant: KOKI HOLDINGS CO., LTD.
    Inventors: Tetsuya MONZEN, Ryosuke NAKANO
  • Publication number: 20190352397
    Abstract: The invention relates to an antibody which binds to myelin oligodendrocyte glycoprotein (MOG), an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment, a nucleic acid containing a nucleotide sequence which encodes the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment, a composition containing the antibody or the antibody fragment and a method for detecting or measuring an antigen that is present in the brain, a method for diagnosing or treating a brain disease, a method for improving the property of an antibody of accumulating in the brain and a method for increasing the amount of an antibody in the brain which use the antibody or the antibody fragment.
    Type: Application
    Filed: December 25, 2017
    Publication date: November 21, 2019
    Applicants: Kyowa Hakko Kirin Co., Ltd., KAGOSHIMA UNIVERSITY
    Inventors: Nobuaki TAKAHASHI, Ryosuke NAKANO, Sayaka MAEDA, Yuji ITO
  • Publication number: 20190276521
    Abstract: An object of the present invention is to provide an antibody which can be a substitute for IVIG and exhibits high binding activity to an Fc? receptor, DNA encoding the antibody, a vector including the DNA, a transformant obtained by the introduction of the vector, a method for manufacturing an antibody by using the transformant, and therapeutic agent for treatment of autoimmune diseases containing the antibody as an active component. The present invention relates to a monoclonal antibody which specifically recognizes a ? chain of human haptoglobin consisting of an amino acid sequence represented by SEQ ID NO: 70 and forms a polyvalent immune complex by binding to the human haptoglobin.
    Type: Application
    Filed: March 28, 2017
    Publication date: September 12, 2019
    Applicant: KYOWA HAKKO KIRIN CO., LTD.
    Inventors: Yuko KATO, Ryosuke NAKANO
  • Publication number: 20160039996
    Abstract: A flame-retardant agent composition containing an organophosphorous compound represented by the general formula (I): wherein R1 and R2 each independently represent an alkyl group having 1 to 5 carbon atoms; R3 and R4 each independently represent a hydrogen atom or an alkyl group having 1 to 5 carbon atoms; Y represents a bond or a group —CH2—, —C(CH3)2—, —S—, —SO2—, —O—, —CO— or —N?N—; k represents 0 or 1; and m represents an integer of 0 to 4 and having a property such that a content of a compound represented by the formula (II): wherein R1, R2 and R3 are as defined in the general formula (I) is 1.8% by area or less when the organophosphorous compound is determined by gel permeation chromatography (GPC).
    Type: Application
    Filed: April 7, 2014
    Publication date: February 11, 2016
    Applicant: DAIHACHI CHEMICAL INDUSTRY CO., LTD.
    Inventors: Fujio KAKUSHOU, Hiroyuki FUKUHARA, Ryosuke NAKANO
  • Publication number: 20080064726
    Abstract: There is provided a novel pyrrolidine derivative represented by the formula (I) or a salt thereof having an excellent DPP-IV inhibitory activity and an excellent pharmacokinetic. On the basis of the action as such, the compound of the present invention is useful for treatment and/or prevention of insulin-dependent diabetes mellitus (type 1 diabetes mellitus) and particularly for non insulin-dependent diabetes mellitus (type 2 diabetes mellitus), insulin-resistant diseases, obesity, etc. [In the formula, -A- is a single bond, —O—, —S—, —NH— or —N(lower alkyl)-; and —B is lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, aryl, non-aromatic hetero ring or aromatic hetero ring and each of those groups may be substituted.
    Type: Application
    Filed: April 25, 2005
    Publication date: March 13, 2008
    Inventors: Masahiko Hayakawa, Ryosuke Nakano, Masako Furutani
  • Patent number: 7268150
    Abstract: Provided is a compound having excellent dipeptidyl peptidase IV-inhibiting activity, and a remedy based on the activity for insulin-dependent diabetes (type 1 diabetes), especially for non insulin-dependent diabetes (type 2 diabetes), insulin-resistant disorders, and obesity.
    Type: Grant
    Filed: July 18, 2003
    Date of Patent: September 11, 2007
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Masahiko Hayakawa, Kenji Negoro, Satoshi Miyamoto, Takayuki Suzuki, Tatsuya Maruyama, Ryosuke Nakano
  • Publication number: 20070128691
    Abstract: Development of a host cell capable of producing a glycoprotein composition such as an antibody composition which is useful in development of medicaments is desired. The present invention provides a cell in which a genomic gene encoding an enzyme relating to a sugar chain modification in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through ?-bond in a complex type N-glycoside-linked sugar chain is knocked out, wherein the cell is naturalized in a serum-free medium and a process for producing a glycoprotein composition using the cell.
    Type: Application
    Filed: October 8, 2004
    Publication date: June 7, 2007
    Inventors: Ryosuke Nakano, Mitsuo Satoh, Shigeru Iida, Miho Inoue, Machi Kusunoki, Satoko Kinoshita, Naoko Ohnuki