Abstract: A fixing device includes: a fixing member that fixes a toner image on a recording medium; a pressure member that forms a fixing pressure portion between the pressure member and the fixing member by making pressure contact with an outer circumferential surface of the fixing member, the fixing pressure portion being passed through by the recording medium holding an unfixed toner image; a heat supplier that supplies heat to the fixing member; and a thermal diffusion member that diffuses heat on a surface of the fixing member by contact with the fixing member.

Abstract: The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome linked IAP (XIAP) and caspase-3, caspase-7 or caspase-9, wherein the IAP regulates the activity of the caspases. The invention provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a caspase such as caspase-3 or caspase-7. The invention also provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a pro-caspase such as pro-caspase-9. In addition, the invention also provides methods for identifying agents that modulate the activity of a caspase in the presence of an IAP and that regulate the activation of a pro-caspase by an IAP.

Abstract: A cleaning member includes a cleaning part whose one end portion comes into contact with a surface of an image carrier, and a supporting part that supports the cleaning part and applies a force for pressing the one end portion of the cleaning part to the surface of the image carrier, wherein a surface of a first portion including the one end portion of the cleaning part is bonded to the supporting part with a first adhesive layer, and a surface of a second portion including the other end portion opposite to the one end portion of the cleaning part is bonded to the supporting part with a second adhesive layer having a Type-A durometer hardness which is lower than that of the first adhesive layer.

Abstract: A cleaning device includes a cleaning blade member that has a tip abutting a surface of an image carrier so as to remove a residue remaining on the surface of the image carrier; an attaching member that includes a first attachment piece to which a base end of the cleaning blade member is attached, and a second attachment piece which is provided so as to intersect the first attachment piece at a predetermined angle; a housing member to which one of the first attachment piece and the second attachment piece is fixed at both ends along a longitudinal direction thereof; and an external force exerting member that exerts an external force in a direction which intersects a surface of the other one of the first attachment piece and the second attachment piece, which is not fixed to the housing member.

Abstract: It is intended to provide an agent for regulating axon extension during neuranagenesis by regulating ephrin-Eph receptor signaling mechanisms and to provide a mouse having abnormal ephrin-Eph receptor signaling mechanisms. The present invention relates to a regulator of axon extension, comprising an agent for promoting or suppressing the function of ?-chimerin, and to a miffy (mfy) mouse derived from a B6 strain, which displays autosomal recessive inheritance of an abnormal walking trait exhibiting a hopping gait with left-right synchronized movement of limbs and has mutation in an ?-chimerin gene.

Abstract: The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome linked IAP (XIAP) and caspase-3, caspase-7 or caspase-9, wherein the IAP regulates the activity of the caspases. The invention provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a caspase such as caspase-3 or caspase-7. The invention also provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a pro-caspase such as pro-caspase-9. In addition, the invention also provides methods for identifying agents that modulate the activity of a caspase in the presence of an IAP and that regulate the activation of a pro-caspase by an IAP.

Abstract: There is provided an image forming mechanism including: an image carrier containing a lubricant in a photosensitive layer that is formed on a surface of the image carrier, and on which an electrostatic latent image is formed; a developing section developing the electrostatic latent image into a visible image by a developer that contains the lubricant; and a cleaning member formed with a first layer that contacts the photosensitive layer, and a second layer that is formed of a material having a lower modulus of repulsion elasticity than the first layer and that is layered with the first layer and that does not contact the surface of the image carrier.

Abstract: A particle behavior analysis system includes a calculation section that, regarding a decomposition portion decomposed in accordance with a decomposition method in a range to be analyzed, considers interaction force with another substance that acts on a particle and calculates behavior of the particle, while performing information communication with other devices; and an output processing section that switches output advisability of an analysis result obtained by the calculation section based on priority of the decomposition portion corresponding to the advisability of output processing of the analysis result.

Abstract: A cleaning member includes a cleaning part whose one end portion comes into contact with a surface of an image carrier, and a supporting part that supports the cleaning part and applies a force for pressing the one end portion of the cleaning part to the surface of the image carrier, wherein a surface of a first portion including the one end portion of the cleaning part is bonded to the supporting part with a first adhesive layer, and a surface of a second portion including the other end portion opposite to the one end portion of the cleaning part is bonded to the supporting part with a second adhesive layer having a Type-A durometer hardness which is lower than that of the first adhesive layer.

Abstract: A method is provided of playing a broadcast program content, which includes: (a) producing a combination-dependent unique key which is unique to a combination of a tuner unit and a computer unit; and (b) in response to issuance of a real-time play command or a recorded-video playback command from a user, playing a broadcast program content in real-time after transmission thereof from the tuner unit to the computer unit, or playing back recorded data after retrieval thereof from a data storage. In an illustrative embodiment, the produced combination-dependent unique key is outputted into an encryptor of the tuner unit for encryption, and the encrypted digital data is inputted into the computer unit. A decryptor of the computer unit is caused to attempt decryption of the encrypted digital data, using the produced combination-dependent unique key.

Abstract: A conventional method of retrieving spheroids formed needs to chemically label the spheroids and may physically damage the spheroids. An apparatus according to the present invention has a nanopillar cell culture sheet, a flow speed generating section, and a spheroid retrieval section. The present invention uses the nanopillar cell culture sheet to provide a mechanism that first forms spheroids, a mechanism that provides a flow speed to the spheroids formed, and a mechanism that retrieves the spheroids released owing to the provided flow speed, without the need for labeling.

Abstract: A method for detecting an abnormal cell based on gene expression analysis, which is useful for cancer diagnosis, is provided. A gene expression analysis method, comprising: measuring the expression level of a transcript of a human MLH1 gene containing the nucleotide sequence as shown in SEQ ID NO: 1 at the 5?-terminus thereof and the expression level of a transcript of a human MLH1 gene containing the nucleotide sequence as shown in SEQ ID NO: 2 at the 5?-terminus thereof, in a biological sample; and comparing the expression levels, thereby detecting a cell positive for microsatellite instability.

Abstract: The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome linked IAP (XIAP) and caspase-3, caspase-7 or caspase-9, wherein the IAP regulates the activity of the caspases. The invention provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a caspase such as caspase-3 or caspase-7. The invention also provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a pro-caspase such as pro-caspase-9. In addition, the invention also provides methods for identifying agents that modulate the activity of a caspase in the presence of an IAP and that regulate the activation of a pro-caspase by an IAP.

Abstract: The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome linked IAP (XIAP) and caspase-3, caspase-7 or caspase-9, wherein the IAP regulates the activity of the caspases. The invention provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a caspase such as caspase-3 or caspase-7. The invention also provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a pro-caspase such as pro-caspase-9. In addition, the invention also provides methods for identifying agents that modulate the activity of a caspase in the presence of an IAP and that regulate the activation of a pro-caspase by an IAP.

Abstract: A card connector system that detachably supports a PC card and electrically connects the PC card to an electrical device. The system includes a temperature sensor to monitor temperature of the PC card to prevent the deleterious effect of heat generated by the PC card on the PC card itself and the electrical device. The sensor detects the surface temperature of the supported PC card and transmits the obtained temperature information to the electrical device. In this case, it is preferable that a transition board 33, electrically connected between the PC card and the electrical device, is used to transmit the temperature information.

Abstract: An object of the present invention is to provide a substrate of Parkin, a system for elucidating the cause of Parkinson's disease using the substrate and a method of screening for a remedy for Parkinson's disease. An animal cell having a DNA encoding a human Pael receptor or a DNA having a variant of the DNA incorporated therein; a non-human mammal having a DNA carrying the aforementioned DNA incorporated therein; a probe comprising the whole or a part of DNA encoding the human Pael receptor; and an antibody specifically recognizing Pael receptor.

Abstract: A card connector system that detachably supports a PC card and electrically connects the PC card to an electrical device. The system includes a temperature sensor to monitor temperature of the PC card to prevent the deleterious effect of heat generated by the PC card on the PC card itself and the electrical device. The sensor detects the surface temperature of the supported PC card and transmits the obtained temperature information to the electrical device. In this case, it is preferable that a transition board 33, electrically connected between the PC card and the electrical device, is used to transmit the temperature information.

Abstract: A card connector system that detachably supports a PC card and electrically connects the PC card to an electrical device. The system includes a temperature sensor to monitor temperature of the PC card to prevent the deleterious effect of heat generated by the PC card on the PC card itself and the electrical device. The sensor detects the surface temperature of the supported PC card and transmits the obtained temperature information to the electrical device. In this case, it is preferable that a transition board 33, electrically connected between the PC card and the electrical device, is used to transmit the temperature information.

Abstract: The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome linked IAP (XIAP) and caspase-3, caspase-7 or caspase-9, wherein the IAP regulates the activity of the caspases. The invention provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a caspase such as caspase-3 or caspase-7. The invention also provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a pro-caspase such as pro-caspase-9. In addition, the invention also provides methods for identifying agents that modulate the activity of a caspase in the presence of an IAP and that regulate the activation of a pro-caspase by an IAP.

Abstract: The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome linked IAP (XIAP) and caspase-3, caspase-7 or caspase-9, wherein the IAP regulates the activity of the caspases. The invention provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a caspase such as caspase-3 or caspase-7. The invention also provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a pro-caspase such as pro-caspase-9. In addition, the invention also provides methods for identifying agents that modulate the activity of a caspase in the presence of an IAP and that regulate the activation of a pro-caspase by an IAP.