Abstract: One of the purposes of the present invention is to provide a method for producing a gene-edited tissue stem cell in an undifferentiated state within a short period of time. Another one of the purposes of the present invention is to provide a method for treating and/or preventing a disease using a gene-edited tissue stem cell in an undifferentiated state. A gene-edited tissue stem cell is produced by a method comprising a step for editing the gene sequence of a target gene in tissue stem cells, and a step for selecting the tissue stem cells having an edited gene sequence, and optionally, further comprising a step for adding a tag to the gene sequence of the target gene and/or a step for activating gene expression of the target gene in the tissue stem cells. The tissue stem cell thus produced is used in treating/preventing diseases.

Abstract: A plurality of flat tablets are held in containing holes (211) by pinching the circumferential edge of the flat tablet (t) at the lowermost position at the lower end of the containing hole, and then pinching state of the tablet (t) at the lowermost position is released thus dropping the plurality of flat tablets (t) under a flat state into a capsule body (m) arranged below. The capsule body can be surely filled with a predetermined number of flat tablets under a flat state by preventing occurrence of flat tablets under a standing state effectively.

Abstract: A plurality of flat tablets are held in containing holes (211) by pinching the circumferential edge of the flat tablet (t) at the lowermost position at the lower end of the containing hole, and then pinching state of the tablet (t) at the lowermost position is released thus dropping the plurality of flat tablets (t) under a flat state into a capsule body (m) arranged below. The capsule body can be surely filled with a predetermined number of flat tablets under a flat state by preventing occurrence of flat tablets under a standing state effectively.