Abstract: A fiber placement device that includes a placement plane on which a reinforcing fiber tow is placed and stacked; a tow arranging mechanism which presses and places the reinforcing fiber tow against and on the placement plane; and a heating mechanism which is configured to heat the placement plane. In one placement cycle, the tow arranging mechanism presses a group of the reinforcing fiber tows against the placement plane heated in advance by the heating mechanism, moves by a predetermined length in a first axial direction to glue and fix the group of the reinforcing fiber tows onto the placement plane, and move the placement plane in a second axial direction which substantially intersects the first axial direction.

Abstract: The present invention relates to a fusion protein containing an erythropoietin polypeptide fused to the Fc region of mammal-derived IgG (hereinafter to be also abbreviated as EPO-Fc fusion protein). The fusion protein in which erythropoietin polypeptide has the amino acid sequence shown in SEQ ID NO: 9 or 10, and the Fc region has the amino acid sequence shown in SEQ ID NO: 3 or 4 is more superior in the property and activity and can be obtained at a high yield.

Abstract: The present invention is directed to a variant of a parent polypeptide containing an Fc region of a dog or cat IgG, that shows a higher binding activity to a dog or cat neonatal Fc receptor (FcRn) than a binding activity of the parent polypeptide to a dog or cat FcRn, wherein the Fc region contains at least one amino acid modification. The variant shows an enhanced FcRn binding activity under acidic conditions. Using the variant, therefore, an antibody (IgG) and Fc fusion protein having longer retention in plasma can be provided.

Abstract: The present invention aims to provide a sheet-shaped reinforcing fiber substrate having shear deformability to conform to a three dimensional shape and restraining the generation of waste pieces to realize a large improve in the yield of reinforcing fibers and a reduction in production cost, and also provide a production method therefor.