Abstract: (Object) An oral sustained-release tablet is provided, which does not cause initial rapid increases in the bloodlevels of 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutylamide (KRP-197) and can maintain constant the blood levels. (Solving means) An oral sustained-release tablet comprises a pharmaceutical composition and a gel-forming material, the pharmaceutical composition containing KRP-197 as an active ingredient.

Abstract: (Object) An oral sustained-release tablet is provided, which does not cause initial rapid increases in the bloodlevels of 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutylamide (KRP-197) and can maintain constant the blood levels. (Solving means) An oral sustained-release tablet comprises a pharmaceutical composition and a gel-forming material, the pharmaceutical composition containing KRP-197 as an active ingredient.

Abstract: Upon performing the clinical study of (S)-2-[3-[N-[4-(4-fluorophenoxy)benzyl]carbamoyl]-4-methoxybenz yl]butanoic acid (hereinafter abbreviated as KRP-101), of which improvement in the lipidmetabolism is expected in a microdose, no oral solid dosage form that allows KRP-101 to be administered quantitatively has been embodied. After mixing KRP-101 with additives (excipient, disintegrator and lubricant), the mixture is granulated, pressed into tablets and coated with coating agent, thereby film-coated tablets uniformly containing a small amount of KRP-101 are obtained, making it possible to administer amicrodose of KRP-101 quantitatively on clinical study.

Abstract: An oral sustained-release tablet is provided, which does not cause initial rapid increases in the bloodlevels of 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutylamide (KRP-197) and can maintain constant the blood levels. (Solving means) An oral sustained-release tablet comprises a pharmaceutical composition and a gel-forming material, the pharmaceutical composition containing KRP-197 as an active ingredient.

Abstract: A flat heat exchange tube comprises an upper wall, a lower wall, right and left side walls interconnecting right and left side edges of the upper and lower walls, and a plurality of reinforcing walls connected between the upper and lower walls, extending longitudinally of the tube and spaced apart from one another. The tube has parallel fluid passages formed inside thereof and extending forward or rearward. Each of the reinforcing walls has a plurality of communication holes arranged at a spacing longitudinally thereof for holding the parallel fluid passages in communication with one another therethrough. The upper surface of the lower wall is provided at a portion thereof forming each of the fluid passages with a plurality of turbulence producing portions extending over the entire width of the fluid passage and arranged at a spacing longitudinally of the passage.

Abstract: A flat heat exchange tube comprises an upper wall, a lower wall, right and left side walls interconnecting right and left side edges of the upper and lower walls, and a plurality of reinforcing walls connected between the upper and lower walls, extending longitudinally of the tube and spaced apart from one another. The tube has parallel fluid passages formed inside thereof and extending forward or rearward. Each of the reinforcing walls has a plurality of communication holes arranged at a spacing longitudinally thereof for holding the parallel fluid passages in communication with one another therethrough. The upper surface of the lower wall is provided at a portion thereof forming each of the fluid passages with a plurality of turbulence producing portions extending over the entire width of the fluid passage and arranged at a spacing longitudinally of the passage.