Abstract: A repetitive clipping treatment device has a cylindrical sheath loaded with a clip series that has plural clips, a manipulating wire to move the clip series in the longitudinal direction of the sheath inside the sheath, a handle main body connected to the sheath and having the manipulating wire arranged therein, a slider to move the manipulating wire in the axial direction of the handle main body, and a slider displacement regulating member to regulate the displacement of the slider in the axial direction to different displacements required for clipping treatment of each clip of the clip series. The plural different displacements corresponding to the respective clips are determined based on the lengths to protrude and the retraction amounts of the respective clips.

Abstract: A multiple clip applicator system for tissue clamping of hemostasis includes clip devices of a train and a flexible sheath. To load the flexible sheath with clip devices, a coupling device is used. A shaft head is positioned on an operating wire in the flexible sheath. A receiving opening is formed in the coupling device, for receiving insertion of the shaft head, for mating by press-fit with the fastening clip device. The shaft head is a selected one of plural shaft heads which are different in a shape according to the plural multiple clip assemblies. The receiving opening is a selected one of plural receiving openings having a shape according to corresponding shapes of the plural shaft heads, and adapted to preventing a second shaft head from entry in a first receiving opening and preventing a first shaft head from entry in a second receiving opening.