Patents by Inventor Ryu Nagata
Ryu Nagata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11976062Abstract: The present invention provides a compound, a salt thereof, or a prodrug thereof as a compound effective for preventing and/or treating fibrosis, the compound being represented by formula (1) (wherein A is an optionally substituted benzene ring; B is optionally substituted aryl or optionally substituted heteroaryl; X is an oxygen atom or a sulfur atom; Y is a nitrogen atom or a carbon atom, of Y is a single or double bond when Y is a carbon atom, or of Y is a single bond when Y is a nitrogen atom; each R1 independently represents lower alkyl, or two R1s may be bound to each other to form a spiro ring or a crosslinked structure, or two R1s may be bound to each other to form a saturated fused heterocycle together with nitrogen and carbon atoms constituting a ring containing Y; p is 0, 1, or 2; or (R1)p is oxo).Type: GrantFiled: December 1, 2022Date of Patent: May 7, 2024Assignees: OSAKA UNIVERSITY, KYOTO UNIVERSITY, INTER-UNIVERSITY RESEARCH INSTITUTE CORPORATION NATIONAL INSTITUTES OF NATURAL SCIENCESInventors: Ryu Nagata, Yasuo Mori, Masayuki Mori, Motohiro Nishida, Takuro Tomita
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Publication number: 20230114195Abstract: The present invention provides a compound, a salt thereof, or a prodrug thereof as a compound effective for preventing and/or treating fibrosis, the compound being represented by formula (1) (wherein A is an optionally substituted benzene ring; B is optionally substituted aryl or optionally substituted heteroaryl; X is an oxygen atom or a sulfur atom; Y is a nitrogen atom or a carbon atom, of Y? is a single or double bond when Y is a carbon atom, or of Y? is a single bond when Y is a nitrogen atom; each R1 independently represents lower alkyl, or two R1s may be bound to each other to form a spiro ring or a crosslinked structure, or two R1s may be bound to each other to form a saturated fused heterocycle together with nitrogen and carbon atoms constituting a ring containing Y; p is 0, 1, or 2; or (R1)p is oxo).Type: ApplicationFiled: December 1, 2022Publication date: April 13, 2023Inventors: Ryu NAGATA, Yasuo MORI, Masayuki MORI, Motohiro NISHIDA, Takuro TOMITA
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Patent number: 11548882Abstract: The present invention provides a compound, a salt thereof, or a prodrug thereof as a compound effective for preventing and/or treating fibrosis, the compound being represented by formula (1) (wherein A is an optionally substituted benzene ring; B is optionally substituted aryl or optionally substituted heteroaryl; X is an oxygen atom or a sulfur atom; Y is a nitrogen atom or a carbon atom; of Y is a single or double bond when Y is a carbon atom, or of Y is a single bond when Y is a nitrogen atom; each R1 independently represents lower alkyl, or two R1s may be bound to each other to form a spiro ring or a crosslinked structure, or two R1s may be bound to each other to form a saturated fused heterocycle together with nitrogen and carbon atoms constituting a ring containing Y; p is 0, 1, or 2; or (R1)p is oxo).Type: GrantFiled: April 26, 2019Date of Patent: January 10, 2023Assignees: Osaka University, Kyoto University, Inter-University Research Institute Corporation National Institutes of Natural SciencesInventors: Ryu Nagata, Yasuo Mori, Masayuki Mori, Motohiro Nishida, Takuro Tomita
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Publication number: 20210238171Abstract: The present invention provides a compound, a salt thereof, or a prodrug thereof as a compound effective for preventing and/or treating fibrosis, the compound being represented by formula (1) (wherein A is an optionally substituted benzene ring; B is optionally substituted aryl or optionally substituted heteroaryl; X is an oxygen atom or a sulfur atom; Y is a nitrogen atom or a carbon atom; of Y is a single or double bond when Y is a carbon atom, or of Y is a single bond when Y is a nitrogen atom; each R1 independently represents lower alkyl, or two R1s may be bound to each other to form a spiro ring or a crosslinked structure, or two R1s may be bound to each other to form a saturated fused heterocycle together with nitrogen and carbon atoms constituting a ring containing Y; p is 0, 1, or 2; or (R1)p is oxo).Type: ApplicationFiled: April 26, 2019Publication date: August 5, 2021Inventors: Ryu NAGATA, Yasuo MORI, Masayuki MORI, Motohiro NISHIDA, Takuro TOMITA
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Publication number: 20110183993Abstract: The present invention relates to a novel cycloalkane derivative which has an excellent psychotropic action.Type: ApplicationFiled: January 28, 2011Publication date: July 28, 2011Applicant: Dainippon Sumitomo Pharma Co., Ltd.Inventors: Ryu Nagata, Mayumi Oda, Norihiko Tanno, Masayuki Muto, Ikutaro Saji
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Publication number: 20100286144Abstract: A compound of the following formula (1), or its prodrug or pharmaceutically acceptable salt thereof, being useful as a diabetic medicine or preventive, or blood sugar regulator, or therapeutic agent for hyperlipemia, etc. wherein the ring Z is an optionally substituted heteroaryl, W4 is a single bond, lower alkylene, etc., Ar2 is an optionally substituted aryl, etc., W3 is a single bond, lower alkylene, etc., Ar1 is an optionally substituted arylene, etc., each of W1 and W2 is an optionally substituted lower alkylene, etc., and R1 is carboxyl, an alkoxycarbonyl.Type: ApplicationFiled: July 21, 2010Publication date: November 11, 2010Inventors: Yoko TAKAHASHI, Ryu Nagata, Kantaro Ushiroda
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Patent number: 7825155Abstract: Disclosed is a compound represented by the formula (1) below, a prodrug thereof or a pharmaceutically acceptable salt of either, which is useful as a therapeutic, preventive or ameliorating agent for diabetes and the like. (In the formula, R3 represents an optionally substituted carbamoyl group or the like; X represents a hydroxyl group or the like; W1 and W2 independently represent a single bond or methylene; R7 and R8 independently represent a hydrogen atom, an optionally substituted alkyl group or the like; and Ar represents an optionally substituted aryl group or the like.Type: GrantFiled: September 13, 2006Date of Patent: November 2, 2010Assignee: Dainippon Sumitomo Pharma Co., Ltd.Inventors: Teruhisa Tokunaga, Tsuyoshi Takasaki, Kozo Yoshida, Ryu Nagata
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Patent number: 7781479Abstract: A compound of the following formula (1), or its prodrug or pharmaceutically acceptable salt thereof, being useful as a diabetic medicine or preventive, or blood sugar regulator, or therapeutic agent for hyperlipemia, etc. wherein the ring Z is an optionally substituted heteroaryl, W4 is a single bond, lower alkylene, etc., Ar2 is an optionally substituted aryl, etc., W3 is a single bond, lower alkylene, etc., Ar1 is an optionally substituted arylene, etc., each of W1 and W2 is an optionally substituted lower alkylene, etc., and R1 is carboxyl, an alkoxycarbonyl.Type: GrantFiled: January 12, 2006Date of Patent: August 24, 2010Assignee: Dainippon Sumitomo Pharma Co., Ltd.Inventors: Yoko Takahashi, Ryu Nagata, Kantaro Ushiroda
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Publication number: 20090131398Abstract: Disclosed is a compound represented by the formula (1) below, a prodrug thereof or a pharmaceutically acceptable salt of either, which is useful as a therapeutic, preventive or ameliorating agent for diabetes and the like. (In the formula, R3 represents an optionally substituted carbamoyl group or the like; X represents a hydroxyl group or the like; W1 and W2 independently represent a single bond or methylene; R7 and R8 independently represent a hydrogen atom, an optionally substituted alkyl group or the like; and Ar represents an optionally substituted aryl group or the like.Type: ApplicationFiled: September 13, 2006Publication date: May 21, 2009Applicant: Dainippon Sumitomo Pharma Co., Ltd.Inventors: Teruhisa Tokunaga, Tsuyoshi Takasaki, Kozo Yoshida, Ryu Nagata
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Publication number: 20080306275Abstract: A heteroaryl derivative of the formula (1): (wherein Ring Z is an optionally substituted heteroaryl, R1 is a carboxyl group or an alkoxycarbonyl group, etc., W1 and W2 are an optionally substituted lower alkylene, Ar1 is an optionally substituted arylene or an optionally substituted heteroarylene, W3 is a single bond, a lower alkylene, a lower alkenylene, etc., W4 is a single bond, —NR10—, etc., Ar2 is an optionally substituted aryl or an optionally substituted heteroaryl), or a prodrug thereof, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: July 15, 2008Publication date: December 11, 2008Applicant: Danippon Sumitomo Pharma Co., Ltd.Inventors: Ken-ichi WATANABE, Katsunori Maruta, Kantaro Ushiroda, Ryu Nagata
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Patent number: 7425642Abstract: A heteroaryl derivative of the formula (1): (wherein Ring Z is an optionally substituted heteroaryl, R1 is a carboxyl group or an alkoxycarbonyl group, etc., W1 and W2 are an optionally substituted lower alkylene, Ar1 is an optionally substituted arylene or an optionally substituted heteroarylene, W3 is a single bond, a lower alkylene, a lower alkenylene, etc., W4 is a single bond, —NR10—, etc., Ar2 is an optionally substituted aryl or an optionally substituted heteroaryl), or a prodrug thereof, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: July 13, 2004Date of Patent: September 16, 2008Assignee: Dainippon Sumitomo Pharma Co. ,Ltd.Inventors: Ken-ichi Watanabe, Katsunori Maruta, Kantaro Ushiroda, Ryu Nagata
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Publication number: 20080167306Abstract: A compound of the following formula (1), or its prodrug or pharmaceutically acceptable salt thereof, being useful as a diabetic medicine or preventive, or blood sugar regulator, or therapeutic agent for hyperlipemia, etc. wherein the ring Z is an optionally substituted heteroaryl, W4 is a single bond, lower alkylene, etc., Ar2 is an optionally substituted aryl, etc., W3 is a single bond, lower alkylene, etc., Ar1 is an optionally substituted arylene, etc., each of W1 and W2 is an optionally substituted lower alkylene, etc., and R1 is carboxyl, an alkoxycarbonyl.Type: ApplicationFiled: January 12, 2006Publication date: July 10, 2008Inventors: Yoko Takahashi, Ryu Nagata, Kantaro Ushiroda
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Patent number: 7220773Abstract: A novel pyrrole derivative represented by the following formula (1) and a salt thereof: wherein R1 means substituted alkenyl, etc.; R2 means substituted benzoyl, etc.; and R3 to R5 each means hydrogen, alkyl, halogeno, etc. The derivative and salt have antidiabetic activity.Type: GrantFiled: April 17, 2002Date of Patent: May 22, 2007Assignee: Dainippon Sumitomo Pharma Co., Ltd.Inventors: Ryu Nagata, Katsunori Maruta, Kiyotaka Iwai, Makoto Kitoh, Kantaro Ushiroda, Kozo Yoshida
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Publication number: 20060194857Abstract: A heteroaryl derivative of the formula (1): (wherein Ring Z is an optionally substituted heteroaryl, R1 is a carboxyl group or an alkoxycarbonyl group, etc., W1 and W2 are an optionally substituted lower alkylene, Ar1 is an optionally substituted arylene or an optionally substituted heteroarylene, W3 is a single bond, a lower alkylene, a lower alkenylene, etc., W4 is a single bond, —NR10—, etc., Ar2 is an optionally substituted aryl or an optionally substituted heteroaryl), or a prodrug thereof, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: July 13, 2004Publication date: August 31, 2006Inventors: Ken-ichi Watanabe, Katsunori Maruta, Kantaro Ushiroda, Ryu Nagata
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Publication number: 20050227978Abstract: Medicament being useful as a fibrosis inhibitor for organs or tissues, which comprises a compound of the formula (I): wherein Ring Z is optionally substituted pyrrole ring, etc.; W2 is —CO—, —SO2—, optionally substituted C1-C4 alkylene, etc.; Ar2 is optionally substituted aryl, etc.; W1 and Ar1 mean the following (1) and (2): (1) W1 is optionally substituted C1-C4 alkylene, etc.; Ar1 is optionally substituted bicyclic heteroaryl having 1 to 4 nitrogen atoms as ring-forming atoms: (2) W1 is optionally substituted C2-C5 alkylene, optionally substituted C2-C5 alkenylene, etc.; and Ar1 is aryl or monocyclic heteroaryl, which is substituted by carboxyl, alkoxycarbonyl, etc. at the ortho- or meta-position thereof with respect to the binding position of W1, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: January 28, 2003Publication date: October 13, 2005Applicant: Sumitomo Pharmaceuticals Co., Ltd.Inventors: Teruhisa Tokunaga, Willian Hume, Makoto Kitoh, Ryu Nagata, Michiko Kishino, Tsutomu Nakagawa, Jun Nagamine, Mutsuo Taiji
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Patent number: 6936736Abstract: A compound of the formula: wherein Ar is optionally substituted phenyl, etc.; n is 0, 1 or 2; R1 is hydogen atom, optionally substituted alkyl, etc.; R2 and R3 are independently optionally substituted alkyl, etc.; R4 and R5 are independently hydrogen atom or optionally substituted alkyl; R6 is hydrogen atom, hydroxy or alkyl; or a pharmaceutically acceptable salt thereof is useful as a medicament for treating retinal degenerative disorders and the like.Type: GrantFiled: March 26, 2002Date of Patent: August 30, 2005Assignee: Sumitomo Manufacturing Company LimitedInventors: Kazuhito Ikeda, Tohru Tatsuno, Hiroki Ogo, Toshio Nishihara, Tatsuya Fujibayashi, Ryu Nagata
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Publication number: 20040209939Abstract: Pyrrole derivatives represented by the following formula: 1Type: ApplicationFiled: May 7, 2004Publication date: October 21, 2004Applicant: Sumitomo Pharmaceuticals Co., Ltd.Inventors: Teruhisa Tokunaga, William Ewan Hume, Makoto Kitoh, Ryu Nagata
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Publication number: 20040162331Abstract: A novel pyrrole derivative represented by the following formula (1) and a salt thereof: 1Type: ApplicationFiled: October 16, 2003Publication date: August 19, 2004Inventors: Ryu Nagata, Katsunori Maruta, Kiyotaka Iwai, Makoto Kitoh, Kantaro Ushiroda, Kozo Yoshida
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Patent number: 6759429Abstract: Pyrrole derivatives represented by the following formula: wherein Ring Z is an optionally substituted pyrrole ring, etc.; W2 is —CO—, —SO2—, an optionally substituted C1-C4 alkylene, etc.; Ar2 is an optionally substituted aryl, etc.; W1 and Ar1 mean the following (1) and (2): (1) W1 is an optionally substituted C1-C4 alkylene, etc.; Ar1 is an optionally substituted bicyclic heteroaryl having 1 to 4 nitrogen atoms as ring-forming atoms: (2) W1 is an optionally substituted C2-C5 alkylene, an optionally substituted C2-C5 alkenylene, etc.; and Ar1 is an aryl or monocyclic heteroaryl, which are substituted by carboxyl, an alkoxycarbonyl, etc. at the ortho- or meta-position thereof with respect to the binding position of W1, or a pharmaceutically acceptable salt thereof. These compounds are useful as medicaments such as a fibrosis inhibitor for organs or tissues.Type: GrantFiled: January 28, 2003Date of Patent: July 6, 2004Assignee: Sumitomo Pharmaceuticals Co., Ltd.Inventors: Teruhisa Tokunaga, William Ewan Hume, Makoto Kitoh, Ryu Nagata
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Publication number: 20030181496Abstract: Pyrrole derivatives represented by the following formula: 1Type: ApplicationFiled: January 28, 2003Publication date: September 25, 2003Inventors: Teruhisa Tokunaga, William Ewan Hume, Makoto Kitoh, Ryu Nagata