Abstract: Provided is a botulinum toxin producing method which is simple achieves a high toxin yield, and obtains a toxin having high specific activity. This botulinum toxin producing method includes: (A) a step in which a botulinum toxin is produced from botulinum toxin-producing bacteria in a medium, and a mixture a is obtained which contains a botulinum toxin, a bacterial component, and a nucleic acid component derived from the botulinum toxin; (B) a step in which the mixture a is subjected to the removal of the bacterial component, and a mixture b is obtained which contains a nucleic acid component and a botulinum toxin; (C) a step in which an endonuclease is added to the mixture b and a mixture c is obtained which contains a nucleic acid degradation product and a botulinum toxin; and (D) a step in which the mixture c is subjected to removal of the nucleic acid degradation product, and an isolated botulinum toxin liquid d is obtained.

Abstract: A cover includes a top wall, a first side wall, a second side wall facing the first side wall, and a lock releasing portion. The first side wall includes a locking portion engageable with a locked portion of a covered body. The second side wall includes an opposed locking portion engageable with an opposed locked portion of the covered body. The lock releasing portion includes: a release operation portion inclined and projecting from the top wall in a cover mounting direction; and a connecting portion connecting the release operation portion with the first side wall around the locking portion or the release operation portion with the locking portion.

Abstract: A fusible link unit includes a locking member having a first locked portion, a second locked portion, and a pair of first abutted portions; a connection section; a first body having a first locking part and a pair of first abutting parts, the first body being extended from the first boundary in a predetermined direction, and the first boundary being a boundary extending in a direction that intersects a deployed direction of the first abutting parts; and a second body having a second locking part and a pair of second abutting parts, and extending in the same direction as the first body from the second boundary, the second boundary being a boundary extending in a direction that intersects a deployed direction of the second abutting part.

Abstract: A fusible link unit includes a locking member having a first locked portion, a second locked portion, and a pair of first abutted portions; a connection section; a first body having a first locking part and a pair of first abutting parts, the first body being extended from the first boundary in a predetermined direction, and the first boundary being a boundary extending in a direction that intersects a deployed direction of the first abutting parts; and a second body having a second locking part and a pair of second abutting parts, and extending in the same direction as the first body from the second boundary, the second boundary being a boundary extending in a direction that intersects a deployed direction of the second abutting part.

Abstract: Provided is a botulinum toxin producing method which is simple achieves a high toxin yield, and obtains a toxin having high specific activity. This botulinum toxin producing method includes: (A) a step in which a botulinum toxin is produced from botulinum toxin-producing bacteria in a medium, and a mixture a is obtained which contains a botulinum toxin, a bacterial component, and a nucleic acid component derived from the botulinum toxin; (B) a step in which the mixture a is subjected to the removal of the bacterial component, and a mixture b is obtained which contains a nucleic acid component and a botulinum toxin; (C) a step in which an endonuclease is added to the mixture b and a mixture c is obtained which contains a nucleic acid degradation product and a botulinum toxin; and (D) a step in which the mixture c is subjected to removal of the nucleic acid degradation product, and an isolated botulinum toxin liquid d is obtained.

Abstract: An attachment structure includes a housing and a plate-shaped cover attached to the housing. The cover has a locking portion to fix the cover to the housing. The housing has a locked portion engaged with the locking portion to regulate a movement of the cover in a direction separating from the housing. The attachment structure is configured to engage the locking portion and the locked portion at an engagement place while the cover and the housing are pressed each other in directions separating from each other at a pressing place distant from the engagement place, and to form a space between the cover and the housing in a region between the pressing place and the engagement place, when the cover is attached to the housing.

Abstract: A cover includes a top wall, a first side wall, a second side wall facing the first side wall, and a lock releasing portion. The first side wall includes a locking portion engageable with a locked portion of a covered body. The second side wall includes an opposed locking portion engageable with an opposed locked portion of the covered body. The lock releasing portion includes: a release operation portion inclined and projecting from the top wall in a cover mounting direction; and a connecting portion connecting the release operation portion with the first side wall around the locking portion or the release operation portion with the locking portion.

Abstract: An attachment structure includes a housing and a plate-shaped cover attached to the housing. The cover has a locking portion to fix the cover to the housing. The housing has a locked portion engaged with the locking portion to regulate a movement of the cover in a direction separating from the housing. The attachment structure is configured to engage the locking portion and the locked portion at an engagement place while the cover and the housing are pressed each other in directions separating from each other at a pressing place distant from the engagement place, and to form a space between the cover and the housing in a region between the pressing place and the engagement place, when the cover is attached to the housing.