Abstract: The present invention provides a polypeptide comprising a modified Fc region of an IgG, and a modified Fcy receptor that binds specifically to the polypeptide, and methods for treating or preventing a disease or a disorder in a patient using immunotherapy.

Abstract: A transmission device includes: a code generator configured to generate delay measurement information; an insertion unit configured to sequentially insert the delay measurement information generated by the code generator, in each of delay measurement signals in a plurality of frames, and to sequentially transmit the plurality of frames sequentially inserted with the delay measurement information to a counterpart device on a transmission path whose path delay time is to be measured; and a detector configured to receive a plurality of frames transmitted from the counterpart device and to detect the delay measurement information included in each of delay measurement signals in the plurality of received frames.

Abstract: Novel anti-human CTGF antibodies having excellent binding activity and/or neutralizing activity, as compared with conventional anti-human CTGF antibodies, are useful for treating various diseases in which human CTGF is involved in pathogenesis, including renal diseases such as chronic kidney disease and diabetic nephropathy.

Abstract: A transmission device includes: a code generator configured to generate delay measurement information; an insertion unit configured to sequentially insert the delay measurement information generated by the code generator, in each of delay measurement signals in a plurality of frames, and to sequentially transmit the plurality of frames sequentially inserted with the delay measurement information to a counterpart device on a transmission path whose path delay time is to be measured; and a detector configured to receive a plurality of frames transmitted from the counterpart device and to detect the delay measurement information included in each of delay measurement signals in the plurality of received frames.

Abstract: [Problem] An object of the present invention is to provide an anti-human CTGF antibody having excellent binding activity and/or neutralizing activity, as compared with conventional anti-human CTGF antibodies, and means for preventing or treating various diseases in which human CTGF is involved in pathogenesis, including renal diseases such as chronic kidney disease and diabetic nephropathy, using the anti-human CTGF antibody. [Means for Solution] An anti-human CTGF antibody includes: a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO: 10; and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO: 4.

Abstract: An NPY Y2 agonist is used as a therapeutic agent for a disease accompanied by diarrhea. A compound capable of treating the disease can be evaluated and screened by examining the compound on the targeting to an NPY Y2 receptor. An agent capable of inhibiting the diarrhea by a novel mechanism of action; and a method for evaluation of a compound, including the screening for the agent.

Abstract: The present invention has its object to provide an agent capable of ameliorating the intestinal tract dysfunction through a novel mechanism of action. It also has its object to provide a method for the evaluation of a compound, including the screening of the agent. A disease accompanied by intestinal tract dysfunction can be ameliorated or treated by using an NPY Y4 agonist as a therapeutic agent. A compound capable of ameliorating or treating a disease accompanied by intestinal tract dysfunction can be evaluated or screened by evaluating a compound targeting to an NPY Y4 receptor.

Abstract: In order to increase the efficiency of large-capacity transmission, the continuity of divided signals generated by dividing a multiplexed signal is maintained and the original large-capacity multiplexed signal is restored. A signal dividing section divides a multiplexed signal to generate a plurality of divided signals in the STS or STM transmission interface format. A guarantee information adding section adds guarantee information for guaranteeing the continuity of the divided signals to each of the divided signals to generate transmission signals. A signal sending section sends the transmission signals via a transmission line in the transmission interface format. A signal receiving section receives the transmission signals. A signal restoring section restores the multiplexed signal by constructing the divided signals on the basis of the guarantee information.

Abstract: In order to increase the efficiency of large-capacity transmission, the continuity of divided signals generated by dividing a multiplexed signal is maintained and the original large-capacity multiplexed signal is restored. A signal dividing section divides a multiplexed signal to generate a plurality of divided signals in the STS or STM transmission interface format. A guarantee information adding section adds guarantee information for guaranteeing the continuity of the divided signals to each of the divided signals to generate transmission signals. A signal sending section sends the transmission signals via a transmission line in the transmission interface format. A signal receiving section receives the transmission signals. A signal restoring section restores the multiplexed signal by constructing the divided signals on the basis of the guarantee information.

Abstract: Proposed is an optical clock distribution system in the WDM network, which particularly relates to a system to control clock synchronization between optical transmission devices constituting an optical communication network. The optical clock distribution system includes an optical clock generator converting a clock signal of PRC (Primary Reference Clock) level into an optical clock signal having a wavelength ?0; a wavelength multiplexer wavelength-multiplexing the optical clock signal having wavelength ?0 together with other optical wavelength data; and a wavelength-demultiplexer provided in a unit of the network, wavelength-demultiplexing the optical clock signal having wavelength ?0, wherein the other optical wavelength data are processed in the unit of the network using the wavelength-demultiplexed optical clock signal having wavelength ?0 as a reference clock.

Abstract: An innovative health food for good sleepy is provided for improving the factors that interfere with sleep as much as possible and is suitable for attaining good sleep and deep sleep mainly comprising herbal medicines in combination. The health food for good sleep contains a Panax ginseng extract, a Ginkgo biloba leaf extract, a Ganoderma lucidum extract, and calcium, which are mixed together in predetermined proportions. For example, the mixture contains 0.5 to 1.0 parts by weight of the Ginkgo biloba leaf extract, 0.1 to 0.5 parts by weight of the Ganoderma lucidum extract, and 0.1 to 1.0 parts by weight of calcium with respect to 1 part by weight of the Panax ginseng extract.

Abstract: A network synchronization controller and method for effectively preventing a timing loop from happening in a synchronous network. A clock status message controller, disposed in each network element on the network, produces and sends clock status messages which are each composed of clock quality data and synchronization control data. The clock quality data indicates the quality level of a clock signal that each network element supplies to its neighboring network elements. The synchronization control data contains information to be used to make the network synchronized with a single reference timing source. A clock selector chooses one of the clock signals received from other network elements, based on the clock status messages received along with the clock signals.

Abstract: Proposed is an optical clock distribution system in the WDM network, which particularly relates to a system to control clock synchronization between optical transmission devices constituting an optical communication network. The optical clock distribution system includes an optical clock generator converting a clock signal of PRC (Primary Reference Clock) level into an optical clock signal having a wavelength &lgr;0; a wavelength multiplexer wavelength-multiplexing the optical clock signal having wavelength &lgr;0 together with other optical wavelength data; and a wavelength-demultiplexer provided in a unit of the network, wavelength-demultiplexing the optical clock signal having wavelength &lgr;0, wherein the other optical wavelength data are processed in the unit of the network using the wavelength-demultiplexed optical clock signal having wavelength &lgr;0 as a reference clock.

Abstract: In order to increase the efficiency of large-capacity transmission, the continuity of divided signals generated by dividing a multiplexed signal is maintained and the original large-capacity multiplexed signal is restored. A signal dividing section divides a multiplexed signal to generate a plurality of divided signals in the STS or STM transmission interface format. A guarantee information adding section adds guarantee information for guaranteeing the continuity of the divided signals to each of the divided signals to generate transmission signals. A signal sending section sends the transmission signals via a transmission line in the transmission interface format. A signal receiving section receives the transmission signals. A signal restoring section restores the multiplexed signal by constructing the divided signals on the basis of the guarantee information.

Abstract: In a mesh-type network, a managing section manages QoS (Quality of Service) information, which is accumulated QoS information (inter-neighboring-node QoS information q) between neighboring node apparatuses, about QoS for candidate signal transmission routes in the network at the individual node apparatuses. And a control section controls a signal transmission route selection operation at the self node apparatus based on the network QoS information Q being managed by the managing section. With this construction, it is possible to set/manage a line route satisfying a desired QoS independently at the individual node apparatuses with maximum ease and flexibleness.