Patents by Inventor Ryuichi Takeyama

Ryuichi Takeyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide-compound cyclization method
    Patent number: 11891457
    Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.
    Type: Grant
    Filed: September 3, 2020
    Date of Patent: February 6, 2024
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Shiori Kariyuki, Takeo Iida, Miki Kojima, Ryuichi Takeyama, Mikimasa Tanada, Tetsuo Kojima, Hitoshi Iikura, Atsushi Matsuo, Takuya Shiraishi, Takashi Emura, Kazuhiko Nakano, Koji Takano, Kousuke Asou, Takuya Torizawa, Ryusuke Takano, Nozomi Hisada, Naoaki Murao, Atsushi Ohta, Kaori Kimura, Yusuke Yamagishi, Tatsuya Kato
  • Method for producing peptide, and method for processing bases
    Patent number: 11492369
    Abstract: It was found that a salt formed of an acid and a base having characteristics set forth below can inactivate a deprotecting agent, thereby suppressing redundant peptide elongation: (i) the base is different in type from a base used as a deprotecting agent, and (ii) a conjugate acid of the base has a pKa smaller than that of a conjugate acid of a base used as a deprotecting agent.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: November 8, 2022
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Kenichi Nomura, Ryuichi Takeyama
  • PEPTIDE-COMPOUND CYCLIZATION METHOD
    Publication number: 20210061860
    Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.
    Type: Application
    Filed: September 3, 2020
    Publication date: March 4, 2021
    Applicant: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Shiori KARIYUKI, Takeo Ilda, Miki Kojima, Ryuichi Takeyama, Mikimasa Tanada, Tetsuo Kojima, Hitoshi Ilkura, Atsushi Matsuo, Takuya Shiraishi, Takashi Emura, Kazuhiko Nakano, Koji Takano, Kousuke Asou, Takuya Torizawa, Ryusuke Takano, Nozomi Hisada, Naoaki Murao, Atsushi Ohta, Kaori Kimura, Yusuke Yamagishi, Tatsuya Kato
  • METHOD FOR PRODUCING PEPTIDE, AND METHOD FOR PROCESSING BASES
    Publication number: 20200339623
    Abstract: It was found that a salt formed of an acid and a base having characteristics set forth below can inactivate a deprotecting agent, thereby suppressing redundant peptide elongation: (i) the base is different in type from a base used as a deprotecting agent, and (ii) a conjugate acid of the base has a pKa smaller than that of a conjugate acid of a base used as a deprotecting agent.
    Type: Application
    Filed: December 14, 2018
    Publication date: October 29, 2020
    Inventors: Kenichi NOMURA, Ryuichi TAKEYAMA
  • CYCLIC PEPTIDE COMPOUND HAVING HIGH MEMBRANE PERMEABILITY, AND LIBRARY CONTAINING SAME
    Publication number: 20200131669
    Abstract: The present inventors have found that when screening for cyclic peptide compounds that can specifically bind to a target molecule, the use of a library including cyclic peptide compounds having a long side chain in the cyclic portion can improve the hit rate for cyclic peptide compounds that can specifically bind to the target molecule. Meanwhile, the present inventors have found that tryptophan and tyrosine residues, which have conventionally been used in oral low molecular-weight pharmaceuticals and are amino acid residues having an indole skeleton or a hydroxyphenyl group, are not suitable for peptides intended to attain high membrane permeability.
    Type: Application
    Filed: June 8, 2018
    Publication date: April 30, 2020
    Inventors: Terushige MURAOKA, Takeo IIDA, Atsushi MATSUO, Ryuichi TAKEYAMA, Mikimasa TANADA, Shota TANAKA, Ryuji HAYASHI, Machiko FUJINO, Hitoshi IIKURA
  • PEPTIDE-COMPOUND CYCLIZATION METHOD
    Publication number: 20160311858
    Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.
    Type: Application
    Filed: May 27, 2016
    Publication date: October 27, 2016
    Applicant: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Shiori Kariyuki, Takeo Iida, Miki Kojima, Ryuichi Takeyama, Mikimasa Tanada, Tetsuo Kojima, Hitoshi Iikura, Atsushi Matsuo, Takuya Shiraishi, Takashi Emura, Kazuhiko Nakano, Koji Takano, Kousuke Asou, Takuya Torizawa, Ryusuke Takano, Nozomi Hisada, Naoaki Murao, Atsushi Ohta, Kaori Kimura, Yusuke Yamagishi, Tatsuya Kato
  • Peptide-compound cyclization method
    Patent number: 9409952
    Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: August 9, 2016
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Shiori Kariyuki, Takeo Iida, Miki Kojima, Ryuichi Takeyama, Mikimasa Tanada, Tetsuo Kojima, Hitoshi Iikura, Atsushi Matsuo, Takuya Shiraishi, Takashi Emura, Kazuhiko Nakano, Koji Takano, Kousuke Asou, Takuya Torizawa, Ryusuke Takano, Nozomi Hisada, Naoaki Murao, Atsushi Ohta, Kaori Kimura, Yusuke Yamagishi, Tatsuya Kato
  • PEPTIDE-COMPOUND CYCLIZATION METHOD
    Publication number: 20150080549
    Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.
    Type: Application
    Filed: December 28, 2012
    Publication date: March 19, 2015
    Inventors: Shiori Kariyuki, Takeo Iida, Miki Kojima, Ryuichi Takeyama, Mikimasa Tanada, Tetsuo Kojima, Hitoshi Iikura, Atsushi Matsuo, Takuya Shiraishi, Takashi Emura, Kazuhiko Nakano, Koji Takano, Kousuke Asou, Takuya Torizawa, Ryusuke Takano, Nozomi Hisada, Naoaki Murao, Atsushi Ohta, Kaori Kimura, Yusuke Yamagishi, Tatsuya Kato