Patents by Inventor Ryuji Furuta

Ryuji Furuta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5401643
    Abstract: A simple and efficient method of preparing active recombinant human neutrophil chemotactic factor. The human neutrophil chemotactic factor (NCF) is solubilized from a transformant cell homogenate using urea or guanidine hydrochloride. The polypeptide is further purified from the solution using conventional protocols such as CM-Sepharose CL-6B, HW-55 column, etc.. By using this method, large amounts of active human NCF can be recovered and purified.
    Type: Grant
    Filed: March 23, 1992
    Date of Patent: March 28, 1995
    Assignees: Dainippon Pharmaceutical Co., Ltd., The United States of America as represented by the Department of Health and Human Services
    Inventors: Masaaki Yamada, Ryuji Furuta, Junichi Yamagishi, Kouji Matsushima
  • Patent number: 5306627
    Abstract: An expression vector in which a DNA encoding a human neutrophil chemotactic factor polypeptide is inserted, a transformant (a host cell transformed with the expression vector), and a process for production of the said polypeptide by using the said transformant.
    Type: Grant
    Filed: June 4, 1991
    Date of Patent: April 26, 1994
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Masaaki Yamada, Ryuji Furuta, Junichi Yamagishi, Kouji Matsushima, Teizo Yoshimura
  • Patent number: 5290917
    Abstract: Novel polypeptides having a modified amino acid sequence of human interleukin 1.alpha. polypeptides in which a certain amino acid residue(s) in said amino acid sequence is(are) exchanged for other amino acid residue(s). Said polypeptides having no capacity of induction of production of prostaglandin E.sub.2 while maintaining other biological activities of human interleukin 1 such as activation of lymphocyte and being expected to be useful as a medicament.
    Type: Grant
    Filed: April 5, 1991
    Date of Patent: March 1, 1994
    Assignee: Dainippon Pharmaceutical Co., Ltd.
    Inventors: Michiko Yamayoshi, Hitoshi Kawashima, Junichi Yamagishi, Hirotada Kotani, Ryuji Furuta, Toshikazu Fukui
  • Patent number: 4990455
    Abstract: A human TNF polypeptide mutant having an amino acid sequence of modified human TNF polypeptide, a DNA having a base sequence encoding the above human TNF polypeptide mutant and a method of producing the above human TNF polypeptide mutant by culturing a host transformed with a vector having inserted therein the above DNA. The above human TNF polypeptide mutant is soluble and has antitumor activity.
    Type: Grant
    Filed: June 22, 1987
    Date of Patent: February 5, 1991
    Assignee: Dainippon Pharmaceutical Co., Ltd.
    Inventors: Junichi Yamagishi, Hitoshi Kawashima, Ryuji Furuta, Hirotada Kotani, Katuhisa Nakata
  • Patent number: 4545932
    Abstract: Novel glucosaminyl muramyl peptide derivatives of the formula: ##STR1## wherein X is hydrogen atom or a group of the formula: R.sub.1 CO--, Y is hydroxy group or a group of the formula: --OR.sub.2, ##STR2## R.sub.1 is an alkyl or alkenyl group, R.sub.2 is a lower alkyl group or a phenylalkyl group, R.sub.3 and R.sub.4 are the same or different and are each hydrogen atom or an alkyl group, Y' is hydroxy group or a group of the formula: --OR.sub.2 or ##STR3## (D) and (L) mean the configuration, provided that when X is hydrogen atom, Y is a group of the formula: ##STR4## and their pharmaceutically acceptable salts. They have excellent biological activities such as potentiating activity of nonspecific resistance to microbial infections and immunostimulant activity and hence are useful in the prophylaxis and treatment of various microbial infections.
    Type: Grant
    Filed: May 13, 1983
    Date of Patent: October 8, 1985
    Assignee: Dainippon Pharmaceutical Co., Ltd.
    Inventors: Yoshiyuki Takase, Ryuji Furuta, Shigeo Kawata, Shunsuke Naruto, Shinichi Nakamura, Akira Minami