Patents by Inventor Ryuji Tao
Ryuji Tao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10294519Abstract: A convenient method for nucleic acid analysis is provided, which enables 1000 or more types of nucleic acid to be analyzed collectively with high comprehensiveness and with a dynamic range of at least four digits. In particular, provided is a very effective analytical method especially for untranslated RNAs and microRNAs, of which the types of target nucleic acids is 10000 or lower. Nucleic acids can be analyzed conveniently and rapidly with high comprehensiveness and quantitative performance at single-molecule sensitivity and resolution by following the steps of: preparing a group of target nucleic acid fragments one molecule at a time and hybridizing the nucleic acid molecules, which have known base sequences and have been labeled with the fluorescence substances, with the group of the target nucleic acid fragments to detect the fluorescence substances labeling the hybridized nucleic acid molecules.Type: GrantFiled: May 16, 2012Date of Patent: May 21, 2019Assignee: Hitachi High-Technologies CorporationInventors: Toshiro Saito, Koshin Hamasaki, Satoshi Takahashi, Muneo Maeshima, Kyoko Imai, Kazumichi Imai, Ryuji Tao
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Patent number: 9822399Abstract: The method for analyzing biomolecules, includes the steps of: immobilizing biomolecules to be analyzed on surfaces of magnetic microparticles; reacting labeled probe molecules with the biomolecules to be analyzed; collecting and immobilizing the microparticles on a support substrate; and measuring a label on the support substrate. Since single-molecule immobilized magnetic microparticles are used in the present invention, the number of biomolecules can be counted, and since hybridization and an antigen-antibody reaction are performed with the microparticles having biomolecules immobilized thereon dispersed, the reaction can be rapidly performed. Further, the type and the abundance of biomolecules of interest can be determined at a single molecular level, so as to evaluate, in particular, the absolute concentration of biomolecules.Type: GrantFiled: October 4, 2012Date of Patent: November 21, 2017Assignee: Hitachi High-Technologies CorporationInventors: Toshiro Saito, Koshin Hamasaki, Satoshi Takahashi, Muneo Maeshima, Kyoko Imai, Kazumichi Imai, Ryuji Tao
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Publication number: 20140295430Abstract: The method for analyzing biomolecules, includes the steps of: immobilizing biomolecules to be analyzed on surfaces of magnetic microparticles; reacting labeled probe molecules with the biomolecules to be analyzed; collecting and immobilizing the microparticles on a support substrate; and measuring a label on the support substrate. Since single-molecule immobilized magnetic microparticles are used in the present invention, the number of biomolecules can be counted, and since hybridization and an antigen-antibody reaction are performed with the microparticles having biomolecules immobilized thereon dispersed, the reaction can be rapidly performed. Further, the type and the abundance of biomolecules of interest can be determined at a single molecular level, so as to evaluate, in particular, the absolute concentration of biomolecules.Type: ApplicationFiled: October 4, 2012Publication date: October 2, 2014Inventors: Toshiro Saito, Koshin Hamasaki, Satoshi Takahashi, Muneo Maeshima, Kyoko Imai, Kazumichi Imai, Ryuji Tao
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Publication number: 20140200162Abstract: A convenient method for nucleic acid analysis is provided, which enables 1000 or more types of nucleic acid to be analyzed collectively with high comprehensiveness and with a dynamic range of at least four digits. In particular, provided is a very effective analytical method especially for untranslated RNAs and microRNAs, of which the types of target nucleic acids is 10000 or lower. Nucleic acids can be analyzed conveniently and rapidly with high comprehensiveness and quantitative performance at single-molecule sensitivity and resolution by following the steps of: preparing a group of target nucleic acid fragments one molecule at a time and hybridizing the nucleic acid molecules, which have known base sequences and have been labeled with the fluorescence substances, with the group of the target nucleic acid fragments to detect the fluorescence substances labeling the hybridized nucleic acid molecules.Type: ApplicationFiled: May 16, 2012Publication date: July 17, 2014Applicant: HITACHI HIGH TECHNOLOGIES CORPORATIONInventors: Toshiro Saito, Koshin Hamasaki, Satoshi Takahashi, Muneo Maeshima, Kyoko Imai, Kazumichi Imai, Ryuji Tao
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Patent number: 8632725Abstract: An automatic analyzer according to the present invention is compact, mounting great number of reagents, having high processing ability. Reagent disks are arranged at inside and outside of a reaction disk. A reagent probe can inject a reagent into the position which is common position of both reagent disks. One of plural reagent probes approaches to one of reagent disks at one cycle. Plural reagent probes alternatively approach to the reagent disk. Therefore, the first reagents and the second reagents can be placed on both reagent disks. The mounting number of reagents can be increased without enlarging an analyzer. The cycle time can be shortened to make an automatic analyzer to have high processing ability.Type: GrantFiled: June 26, 2013Date of Patent: January 21, 2014Assignee: Hitachi High-Technologies CorporationInventors: Isao Yamazaki, Ryuji Tao, Katsuaki Takahashi
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Publication number: 20130287629Abstract: An automatic analyzer according to the present invention is compact, mounting great number of reagents, having high processing ability. Reagent disks are arranged at inside and outside of a reaction disk. A reagent probe can inject a reagent into the position which is common position of both reagent disks. One of plural reagent probes approaches to one of reagent disks at one cycle. Plural reagent probes alternatively approach to the reagent disk. Therefore, the first reagents and the second reagents can be placed on both reagent disks. The mounting number of reagents can be increased without enlarging an analyzer. The cycle time can be shortened to make an automatic analyzer to have high processing ability.Type: ApplicationFiled: June 26, 2013Publication date: October 31, 2013Inventors: Isao Yamazaki, Ryuji Tao, Katsuaki Takahashi
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Patent number: 8496877Abstract: An automatic analyzer according to the present invention is compact, mounting great number of reagents, having high processing ability. Reagent disks are arranged at inside and outside of a reaction disk. A reagent probe can inject a reagent into the position which is common position of both reagent disks. One of plural reagent probes approaches to one of reagent disks at one cycle. Plural reagent probes alternatively approach to the reagent disk. Therefore, the first reagents and the second reagents can be placed on both reagent disks. The mounting number of reagents can be increased without enlarging an analyzer. The cycle time can be shortened to make an automatic analyzer to have high processing ability.Type: GrantFiled: June 21, 2012Date of Patent: July 30, 2013Assignee: Hitachi High-Technologies CorporationInventors: Isao Yamazaki, Ryuji Tao, Katsuaki Takahashi
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Publication number: 20120258012Abstract: An automatic analyzer according to the present invention is compact, mounting great number of reagents, having high processing ability. Reagent disks are arranged at inside and outside of a reaction disk. A reagent probe can inject a reagent into the position which is common position of both reagent disks. One of plural reagent probes approaches to one of reagent disks at one cycle. Plural reagent probes alternatively approach to the reagent disk. Therefore, the first reagents and the second reagents can be placed on both reagent disks. The mounting number of reagents can be increased without enlarging an analyzer. The cycle time can be shortened to make an automatic analyzer to have high processing ability.Type: ApplicationFiled: June 21, 2012Publication date: October 11, 2012Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Isao Yamazaki, Ryuji Tao, Katsuaki Takahashi
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Patent number: 7105351Abstract: Sample sampling to an analysis apparatus 200 or 820 for analyzing a biochemical analysis item is performed by a pipetting device 202 or 840 which uses a repetitively used pipette nozzle, and sample sampling to an analysis apparatus 100 or 810 for analyzing an immune analysis item is performed by a pipetting device 102 or 830 which uses a disposable nozzle tip. A sample bottle containing a sample to be analyzed on both of a biochemical analysis item and an immune analysis item is sample-pipetted by the nozzle tip first, and then transported so as to be sample-pipetted by the pipette nozzle.Type: GrantFiled: March 25, 2002Date of Patent: September 12, 2006Assignee: Hitachi, Ltd.Inventors: Shigeki Matsubara, Kyoko Imai, Ryuji Tao
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Publication number: 20060183244Abstract: Sample sampling to an analysis apparatus 200 or 820 for analyzing a biochemical analysis item is performed by a pipetting device 202 or 840 which uses a repetitively used pipette nozzle, and sample sampling to an analysis apparatus 100 or 810 for analyzing an immune analysis item is performed by a pipetting device 102 or 830 which uses a disposable nozzle tip. A sample bottle containing a sample to be analyzed on both of a biochemical analysis item and an immune analysis item is sample-pipetted by the nozzle tip first, and then transported so as to be sample-pipetted by the pipette nozzle.Type: ApplicationFiled: April 5, 2006Publication date: August 17, 2006Inventors: Shigeki Matsubara, Kyoko Imai, Ryuji Tao
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Publication number: 20060177941Abstract: Sample sampling to an analysis apparatus 200 or 820 for analyzing a biochemical analysis item is performed by a pipetting device 202 or 840 which uses a repetitively used pipette nozzle, and sample sampling to an analysis apparatus 100 or 810 for analyzing an immune analysis item is performed by a pipetting device 102 or 830 which uses a disposable nozzle tip. A sample bottle containing a sample to be analyzed on both of a biochemical analysis item and an immune analysis item is sample-pipetted by the nozzle tip first, and then transported so as to be sample-pipetted by the pipette nozzle.Type: ApplicationFiled: March 28, 2006Publication date: August 10, 2006Inventors: Shigeki Matsubara, Kyoko Imai, Ryuji Tao
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Publication number: 20060177942Abstract: Sample sampling to an analysis apparatus 200 or 820 for analyzing a biochemical analysis item is performed by a pipetting device 202 or 840 which uses a repetitively used pipette nozzle, and sample sampling to an analysis apparatus 100 or 810 for analyzing an immune analysis item is performed by a pipetting device 102 or 830 which uses a disposable nozzle tip. A sample bottle containing a sample to be analyzed on both of a biochemical analysis item and an immune analysis item is sample-pipetted by the nozzle tip first, and then transported so as to be sample-pipetted by the pipette nozzle.Type: ApplicationFiled: March 28, 2006Publication date: August 10, 2006Inventors: Shigeki Matsubara, Kyoko Imai, Ryuji Tao
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Publication number: 20060165562Abstract: Sample sampling to an analysis apparatus 200 or 820 for analyzing a biochemical analysis item is performed by a pipetting device 202 or 840 which uses a repetitively used pipette nozzle, and sample sampling to an analysis apparatus 100 or 810 for analyzing an immune analysis item is performed by a pipetting device 102 or 830 which uses a disposable nozzle tip. A sample bottle containing a sample to be analyzed on both of a biochemical analysis item and an immune analysis item is sample-pipetted by the nozzle tip first, and then transported so as to be sample-pipetted by the pipette nozzle.Type: ApplicationFiled: March 28, 2006Publication date: July 27, 2006Inventors: Shigeki Matsubara, Kyoko Imai, Ryuji Tao
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Publication number: 20050287039Abstract: Sample sampling to an analysis apparatus 200 or 820 for analyzing a biochemical analysis item is performed by a pipetting device 202 or 840 which uses a repetitively used pipette nozzle, and sample sampling to an analysis apparatus 100 or 810 for analyzing an immune analysis item is performed by a pipetting device 102 or 830 which uses a disposable nozzle tip. A sample bottle containing a sample to be analyzed on both of a biochemical analysis item and an immune analysis item is sample-pipetted by the nozzle tip first, and then transported so as to be sample-pipetted by the pipette nozzle.Type: ApplicationFiled: September 6, 2005Publication date: December 29, 2005Inventors: Shigeki Matsubara, Kyoko Imai, Ryuji Tao
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Patent number: 6924152Abstract: Sample sampling to an analysis apparatus 200 or 820 for analyzing a biochemical analysis item is performed by a pipetting device 202 or 840 which uses a repetitively used pipette nozzle, and sample sampling to an analysis apparatus 100 or 810 for analyzing an immune analysis item is performed by a pipetting device 102 or 830 which uses a disposable nozzle tip. A sample bottle containing a sample to be analyzed on both of a biochemical analysis item and an immune analysis item is sample-pipetted by the nozzle tip first, and then transported so as to be sample-pipetted by the pipette nozzle.Type: GrantFiled: March 25, 2002Date of Patent: August 2, 2005Assignee: Hitachi, Ltd.Inventors: Shigeki Matsubara, Kyoko Imai, Ryuji Tao
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Patent number: 6752960Abstract: An automatic analysis apparatus, in which analysis results of immunoassay analysis items are not influenced by carry-overs between samples even when the same sample container is conveyed both to a biochemical analysis unit and an immunoassay analysis unit to permit sample dispensing. The immunoassay and biochemical analysis units are arranged along a rack conveyor. A carry-over avoidance level is set on a screen every analysis item before start of an analyzing operation. When a sample given an instruction to analyze only analysis items having low carry-over avoidance levels is to be dispensed in the biochemical analysis unit, a dispenser nozzle is subjected to ordinary cleaning by water. When a sample given an instruction to analyze analysis items having high carry-over avoidance levels is to be dispensed in the biochemical analysis unit, a dispenser nozzle is cleaned with a detergent solution and water.Type: GrantFiled: September 20, 2000Date of Patent: June 22, 2004Assignee: Hitachi, Ltd.Inventors: Shigeki Matsubara, Kyoko Imai, Ryuji Tao
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Publication number: 20040105783Abstract: An automatic analyzer according to the present invention is compact, mounting great number of reagents, having high processing ability. Reagent disks are arranged at inside and outside of a reaction disk. A reagent probe can inject a reagent into the position which is common position of both reagent disks. One of plural reagent probes approaches to one of reagent disks at one cycle. Plural reagent probes alternatively approach to the reagent disk. Therefore, the first reagents and the second reagents can be placed on both reagent disks. The mounting number of reagents can be increased without enlarging an analyzer. The cycle time can be shortened to make an automatic analyzer to have high processing ability.Type: ApplicationFiled: July 8, 2003Publication date: June 3, 2004Inventors: Isao Yamazaki, Ryuji Tao, Katsuaki Takahashi
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Patent number: 6579717Abstract: A method for handling specific sample solutions for calibration and quality control by an automatic analytical apparatus in which a sample rack to hold calibrator bottles for required analysis items is set on a rack supply unit by an operator. Identification information of all calibrator bottles on the rack is read out, and data on corresponding calibrator samples are also stored. The operator enters analysis items to be measured, and a measuring channel to be used for calibration. Comparison is made between the planned number of requested calibrations and the number of permissible services to determine whether or not calibrator solution is sufficient. If it is determined to be insufficient, the required number of bottles are displayed according to the difference between the number of permissible services and the number of requests, thereby allowing the operator to add the required number of calibrator bottles.Type: GrantFiled: February 3, 2000Date of Patent: June 17, 2003Assignee: Hitachi, Ltd.Inventors: Shigeki Matsubara, Kyoko Imai, Ryuji Tao
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Publication number: 20020110917Abstract: Sample sampling to an analysis apparatus 200 or 820 for analyzing a biochemical analysis item is performed by a pipetting device 202 or 840 which uses a repetitively used pipette nozzle, and sample sampling to an analysis apparatus 100 or 810 for analyzing an immune analysis item is performed by a pipetting device 102 or 830 which uses a disposable nozzle tip. A sample bottle containing a sample to be analyzed on both of a biochemical analysis item and an immune analysis item is sample-pipetted by the nozzle tip first, and then transported so as to be sample-pipetted by the pipette nozzle.Type: ApplicationFiled: March 25, 2002Publication date: August 15, 2002Inventors: Shigeki Matsubara, Kyoko Imai, Ryuji Tao
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Publication number: 20020106814Abstract: Sample sampling to an analysis apparatus 200 or 820 for analyzing a biochemical analysis item is performed by a pipetting device 202 or 840 which uses a repetitively used pipette nozzle, and sample sampling to an analysis apparatus 100 or 810 for analyzing an immune analysis item is performed by a pipetting device 102 or 830 which uses a disposable nozzle tip. A sample bottle containing a sample to be analyzed on both of a biochemical analysis item and an immune analysis item is sample-pipetted by the nozzle tip first, and then transported so as to be sample-pipetted by the pipette nozzle.Type: ApplicationFiled: March 25, 2002Publication date: August 8, 2002Inventors: Shigeki Matsubara, Kyoko Imai, Ryuji Tao