Abstract: A fluorinated ether compound and a composition capable of forming a light resistant surface layer and an article are provided. The fluorinated ether compound of the present invention has a poly(oxyfluoroalkylene) chain, a reactive silyl group and a group (A) represented by —NR—C(O)— (wherein R is a hydrogen atom or an alkyl group), wherein the carbonyl carbon in the group (A) is bonded to a carbon atom, and the poly(oxyfluoroalkyiene) chain is located at the nitrogen end of the group (A).

Abstract: A substrate with a water and oil repellent layer having excellent abrasion resistance and a method for producing the substrate are provided. The substrate with a water and oil repellent layer contains a substrate, an undercoat layer formed on the surface of the substrate, and a water and oil repellent layer formed on the surface of the undercoat layer. The undercoat layer contains an oxide containing silicon and a specific element. The water and oil repellent layer is made of a hydrolytic condensation compound of a fluorinated ether compound, which is a compound represented by the formula (A1) or a compound represented by the formula (A2): Rf—O—(Rf1O)m—Rf2[—R1—C(—R2-T)a(—R3)3-a]b??(A1) [(T-R2—)a(R3—)3-aC—R1—]bRf2—O—(Rf1O)m—Rf2[—R1—C(—R2-T)a(—R3)3-a]b??(A2).

Abstract: The object is to provide a composition capable of forming a surface layer with excellent abrasion resistance, a substrate with a surface layer, and a method for producing a substrate with a surface layer. It is also an object to provide new compounds and their production methods. The composition of the invention comprises a first component made of a fluorinated ether compound having a poly(oxyfluoroalkylene) chain and a reactive silyl group, and at least one type of second component selected from compound (A) (Rfa—(OXa)m1-La-CZa1?CH2) and compound (B) (CH2?CZb2-Lb2-(OXb)m2-Lb1-CZb1?CH2), where Rfa is a fluoroalkyl group, Xa and Xb are fluoroalkylene groups, La is a single bond or a divalent linking group (but excluding (OXa)na), Lb1 and Lb2 are single bonds or divalent linking groups (but excluding (OXb)nb), Za1, Zb1 and Zb2 are fluorine atoms or trifluoromethyl groups, and m1 and m2 are integers of 2 or more.

Abstract: Provided are a fluorine-containing ether compound that can form a surface layer that excels in durability and a method of manufacturing the same, a fluorine-containing ether composition and a coating liquid, and an article having a surface layer that excels in durability and a method of manufacturing the same. A fluorine-containing ether compound is expressed by the following formula (A1) or (A2): {RfO—(Rf1O)m1—(R1)m2—(CHF)m3—O—(CHF)m4}n1-Q1(-T1)n2?? Formula (A1) (T2)n3-Q2-(CHF)m5—O—(CHF)m6—(R2)m7—O—(Rf2O)m8—(R3)m9—(CHF)m10—O—(CHF)m11-Q3(-T3)n4??Formula (A2), in the above, the symbols in the formulas are as described in the specification.

Abstract: Provided are: a fluorine-containing ether compound, a fluorine-containing ether composition, and a coating liquid that are capable of forming a surface layer having excellent durability; and an article that has a surface layer having excellent durability. The present invention provides a fluorine-containing ether compound represented by formula (A1) or formula (A2) below. RfO—(Rf1O)m—R1-L1-R2-Q1(-T)n??formula (A1) (T-)nQ1-R2-L1-R1—O—(Rf1O)m—R1-L1-R2-Q1(-T)n??formula (A2) In the formulae, symbols are as defined in the description.

Abstract: Provided are a fluorine-containing ether compound, a fluorine-containing ether composition, and a coating liquid, which can form a surface layer having excellent durability, and an article and production method thereof having a surface layer that has excellent durability and that can maintain water and oil repellency, lubricity, and fingerprint stain removability for a long time. The fluorine-containing ether compound includes a polyfluoropolyether chain, a reactive silyl group, and a linking group that includes a group represented by *—O—C(?O)—**, in which the linking group links the polyfluoropolyether chain arranged on the * side and the reactive silyl group arranged on the ** side.

Abstract: Provided are a fluorine-containing ether compound, fluorine-containing ether composition and coating liquid that can form a surface layer having excellent durability, an article having a surface layer that has excellent durability, and a compound that is useful as a raw material of a fluorine-containing ether compound. The fluorine-containing ether compound is represented by the following formula (A1) or formula (A2): Rf—O—(Rf1O)m—Rf2[—R1—C(—R2-T)a(—R3)3-a]b??Formula (A1) [(T-R2—)a(R3—)3-aC—R1—]bRf2—O—(Rf1O)m—Rf2[—R1—C(—R2-T)a(-R3)3-a]b?? Formula (A2) wherein each of the reference signs in the formulas are as described in the specification.

Abstract: The present invention is directed to providing a method of manufacturing a fluorine-containing compound according to which a fluorine-containing compound is manufactured under a relatively moderate reaction condition by use of a readily available compound. A method of manufacturing a fluorine-containing compound includes reacting a compound having a partial structure expressed by a formula (a) below with a Grignard reagent in the presence of a transition metal compound, —CF2—CH2—L??(a) wherein L is a sulfonate group.

Abstract: A fluorinated ether compound and a composition capable of forming a light resistant surface layer and an article are provided. The fluorinated ether compound of the present invention has a poly(oxyfluoroalkylene) chain, a reactive silyl group and a group (A) represented by —NR—C(O)— (wherein R is a hydrogen atom or an alkyl group), wherein the carbonyl carbon in the group (A) is bonded to a carbon atom, and the poly(oxyfluoroalkylene) chain is located at the nitrogen end of the group (A).

Abstract: Compounds of formula (VI), which are useful as therapeutic drugs for diabetes, may be produced by reacting a compound of formula (II) with an acid halogenating agent to give an acid halide; reacting the acid halide with a compound of formula (IV) in the presence of a base, and crystallizing compound (V) or a salt thereof from the reaction system; and subjecting the compound of formula (V) to reductive deprotection in the presence of a metal catalyst, and crystallizing the compound of (VI) or a salt thereof from the reaction system:

Abstract: Sulfonamide compounds of a specific chemical structure in which a sulfonamide group having, as a substituent, a phenyl group or a heterocyclic group having a hetero atom(s) as a constituent element(s) is present at its terminal, and pharmaceutically acceptable salts thereof. These compounds are novel compounds having excellent ?4 integrin-inhibitory action.

Abstract: Compounds of formula (9), which are useful as therapeutic drugs for diabetes, may be produced by the following reaction sequence: (a) diester (3) is synthesized by the reaction of compound (1) and compound (2); (b) ester (4) is synthesized by deprotection of diester (3) (or ester (4) is synthesized by the reaction of compound (5) and compound (2)); (c) ester (4) is converted to acid halide; (d) the acid halide is reacted with an amidinophenol derivative; and (e) the obtained diester derivative is deprotected under acidic conditions, and converted to compound (9): wherein R1 is a halogen atom, R4 is a lower alkyl group, R5 is a lower alkyl group, and R12 is a hydrogen atom or a halogen atom.

Abstract: Compounds of formula (VI), which are useful as therapeutic drugs for diabetes, may be produced by reacting a compound of formula (II) with an acid halogenating agent to give an acid halide; reacting the acid halide with a compound of formula (IV) in the presence of a base, and crystallizing compound (V) or a salt thereof from the reaction system; and subjecting the compound of formula (V) to reductive deprotection in the presence of a metal catalyst, and crystallizing the compound of (VI) or a salt thereof from the reaction system:

Abstract: Provided are sulfonamide derivatives of a specific chemical structure in which a sulfonamide group having, as a substituent, a phenyl group or a heterocyclic group having a hetero atom(s) as a constituent element(s) is present at its terminal, and pharmaceutically acceptable salts thereof. These compounds are novel compounds having excellent ?4 integrin-inhibitory action.

Abstract: The present invention provides a pharmaceutical which possesses an excellent inhibitory effect on NHE3 (Na+/H+ exchanger type 3) and effectively improves diseases or conditions of organs in which NHE3 is expressed.

Abstract: The present invention provides a pharmaceutical which possesses an excellent inhibitory effect on NHE3 (Na+/H+ exchanger type 3) and effectively improves diseases or conditions of organs in which NHE3 is expressed.