Abstract: A mechanism for optimizing insulin infusion rate of a CSII pump for each patient. A continuous subcutaneous insulin infusion therapy uses a continuous subcutaneous insulin pump, which includes: determining a circadian variation curve representing sympathetic nerve activity and that represents parasympathetic nerve activity of a target patient; acquiring an inflection point of each of the circadian variation curves representing the two types of nerve activity; detecting a time that corresponds to the inflection point; and employing the time as a point at which the insulin infusion rate of the continuous subcutaneous insulin infusion pump is changed.

Abstract: A mechanism for optimizing insulin infusion rate of a CSII pump for each patient. A continuous subcutaneous insulin infusion therapy uses a continuous subcutaneous insulin pump, which includes: determining a circadian variation curve representing sympathetic nerve activity and that represents parasympathetic nerve activity of a target patient; acquiring an inflection point of each of the circadian variation curves representing the two types of nerve activity; detecting a time that corresponds to the inflection point; and employing the time as a point at which the insulin infusion rate of the continuous subcutaneous insulin infusion pump is changed.

Abstract: An artificial pancreas includes a blood sugar determination unit for measuring the blood sugar of the living body, an injection unit including a container for a blood sugar control agent and a feed pump for the control agent and adapted to inject the control agent into the living body and an arithmetic control unit for calculating the dose of the control agent and controlling the pump of the injection unit in accordance with the results of the calculation. The pump includes a disc-shaped roller holder which holds a plurality of rollers around its periphery. Each roller includes flanges at opposite ends. An elastic tube extends around the rollers under tension. Magnets are embedded along the periphery of the roller supports and are sensed to determine the amount of pumping which has occurred. Tubular stoppers are provided within stepped grooves in the pump housing to receive the ends of the elastic tubes.

Abstract: An artificial pancreas comprising a blood sugar determination unit for measuring the blood sugar of the living body, an injection unit including a container for a blood sugar control agent and a feed pump for the control agent and adapted to inject the control agent into the living body, and an arithmetic control unit for calculating the dose of the control agent based on the blood sugar measurement and controlling the pump of the injection unit in accordance with the result of calculation. The blood sugar determination unit has an electrode assembly to be inserted into the living body for measuring the blood sugar. The feed pump comprises a plurality of rollers rotatably mounted on a rotatable roller holder along the outer periphery of the holder and an elastic tube having an intermediate portion reeved around some of the rollers under tension.