Abstract: A compound of formula (I): or a pharmaceutically acceptable salt thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of the estrogen receptor, including degrading the estrogen receptor, the treatment of diseases and conditions mediated by the estrogen receptor.

Abstract: Methods, systems, and computer readable media for providing a flexible host memory buffer are disclosed. One method includes allocating an amount of host memory as a host memory buffer accessible by a solid state drive (SSD) as a cache for SSD data. The method further includes caching data from the solid state drive in the host memory buffer. The method further includes monitoring utilization of the host memory buffer. The method further includes dynamically increasing or decreasing the amount of host memory allocated for the host memory buffer based on the utilization.

Abstract: The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins that are degraded and/or otherwise inhibited by bifunctional compounds of the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand that binds to the ubiquitin ligase and on the other end a moiety that binds a target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds of the present invention, consistent with the degradation/inhibition of targeted polypeptides.

Abstract: The present invention relates to compounds of formula (I): wherein R1 is C1-6alkylamino, or C1-6alkoxy; m is an integer having a value of 3, 4, or 5; n is an integer having a value of 0 to 3; p is an integer having a value of 1 or 2 and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

Abstract: The present invention relates to compounds of formula (I): wherein R1 is C1-6alkylamino, or C1-6alkoxy; m is an integer having a value of 3, 4, or 5; n is an integer having a value of 0 to 3; p is an integer having a value of 1 or 2 and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds according to formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular IKK2 activity.

Abstract: Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.

Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds according to Formula (1) and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular 1KK2 activity.

Abstract: Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.

Abstract: The invention relates to the field of components with optical fibers and of associated optical fibers. The invention relates, on the one hand, to a component with optical fiber including an at least partly bent optical fiber (2) which successively comprises, from the center to the periphery, an optical core (10) based on silica, an optical cladding (11) based on silica, and a coating (12) having a transparency to infrared radiation larger than 85%. On the other hand, the invention relates to an optical fiber, successively comprising, from the center to the periphery, an optical core (10) based on silica, an optical cladding (11) based on silica, and a coating (12) having a transparency infrared radiation larger than 85%.

Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds according to formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular IKK2 activity.

Abstract: The invention relates to an optical fibre having a coating comprising at least two layers (4, 5). The first layer 91) comprises the reaction product of a first composition containing at least one polyether urethane (meth) acrylate oligomer, a first (meth)acrylate monomer and a second (meth) acrylate monomer. The second layer (2) comprises the reaction product of a second composition containing at lest one first polyether urethane (meth)acrylate oligomer, a second epoxy (meth) acrylate oligomer, a first (meth)acrylate monomer and a second (meth)acrylate monomer. The invention also relates to an optical fibre stripping method comprising a step (a) consisting in supplying the inventive optical fibre (1) and the stripping means, a step (b) consisting in bringing the optical fibre (1) and the stripping means into contact with each other, and a step (c) consisting in moving the fibre and the stripping means in relation to one another.

Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds according to formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular IKK2 activity.

Abstract: The invention relates to the field of components with optical fibers and of associated optical fibers. The invention relates, on the one hand, to a component with optical fiber including an at least partly bent optical fiber (2) which successively comprises, from the center to the periphery, an optical core (10) based on silica, an optical cladding (11) based on silica, and a coating (12) having a transparency to infrared radiation larger than 85%. On the other hand, the invention relates to an optical fiber, successively comprising, from the center to the periphery, an optical core (10) based on silica, an optical cladding (11) based on silica, and a coating (12) having a transparency infrared radiation larger than 85%.

Abstract: A method is provided for producing a fibered element (FO). The method consists in i) forming an assembly (E) by surrounding a first part (C) of vitreous material, with a second part (G) having first optical properties, ii) then drawing the assembly (E) in a longitudinal direction so as to increase its longitudinal dimension while reducing at least one of its transverse dimensions, this increase and reduction being chosen so as to transform at least certain of the said first optical properties of the second part (G) into second optical properties allowing it to selectively filters in a direction substantially perpendicular to the longitudinal direction of the drawn assembly, photons of which the wavelengths fall in at least one selected spectral band.

Abstract: The invention relates to the field of components with optical fibers and of associated optical fibers. The invention relates, on the one hand, to a component with optical fiber including an at least partly bent optical fiber (2) which successively comprises, from the center to the periphery, an optical core (10) based on silica, an optical cladding (11) based on silica, and a coating (12) having a transparency to infrared radiation larger than 85%. On the other hand, the invention relates to an optical fiber successively comprising, from the center to the periphery, an optical core (10) based on silica, an optical cladding (11) based on silica, and a coating (12) having a transparency to infrared radiation larger than 85%.

Abstract: The present invention relates to an optical fiber (1?) having at least one Bragg grating (11), the fiber comprising a core (2) surrounded successively by cladding (3) and a coating (4), said fiber being obtained by writing said grating in the core and/or the cladding directly through the coating which is made of a material containing an organic substance that is substantially transparent to the ultraviolet type radiation used for writing said grating, wherein the material of said coating contains an inorganic substance that is not miscible with the organic substance and that is distributed in substantially uniform manner in said material.

Abstract: An optical fiber includes a coating comprising a cross-linked network comprising the reaction product of monomers and oligomers and at least one polymer dispersed or interpenetrated in the cross-linked network. The oligomer and polymer components used are at least partially fluorinated. The fiber-coating composition of the invention presents a refractive index that is low while satisfying the conditions for industrial fiber-drawing.

Abstract: The invention relates to the field of components with optical fibers and of associated optical fibers. The invention relates, on the one hand, to a component with optical fiber including an at least partly bent optical fiber (2) which successively comprises, from the center to the periphery, an optical core (10) based on silica, an optical cladding (11) based on silica, and a coating (12) having a transparency to infrared radiation larger than 85%. On the other hand, the invention relates to an optical fiber successively comprising, from the center to the periphery, an optical core (10) based on silica, an optical cladding (11) based on silica, and a coating (12) having a transparency to infrared radiation larger than 85%.

Abstract: An optical fiber (1?) having at least one Bragg grating (11), the fiber comprising a core (2) surrounded successively by cladding (3) and by a coating (4), the grating being obtained by being written directly in the core and/or the cladding of the fiber through the coating which is made of a material that is substantially transparent to ultraviolet type radiation used for writing the grating, and wherein the material of the coating contains a first polymer network interpenetrated by a second polymer.