Abstract: Drug delivery devices and methods are provided for delivering one or more drugs into a biological tissue. The devices include microneedles that may be separable from the drug delivery devices, control drug release rate and/or direction, or a combination thereof. When the microneedles are separable, a force applied to the drug delivery devices may be effective to penetrate a biological tissue with the microneedles and then to separate the microneedles from the drug delivery devices. The drug delivery devices may be capable of achieving discrete periods of drug release. Methods for delivery drug with microneedles also are provided.

Abstract: A method and system for fabricating a dental appliance for orthodontic treatment. The method comprises the steps of obtaining three-dimensional dental data from a patient scan, locating initial tooth positions, generating optimal arch forms, and determining a digital model for fabricating an orthodontic aligner with additive device. The system comprises a scanning apparatus to acquire three-dimensional dental data, and a computer apparatus programmed with instructions for generating optimal arch forms, and determining a digital model for fabricating an orthodontic aligner with additive device.

Abstract: Method and/or apparatus embodiments for 3-D cephalometric analysis of a patient according to the application can display reconstructed volume image data from a computed tomographic scan of a patient's head including segmented dentition elements having an initial arrangement from one or more 2D/3D views; can compute and display a plurality of cephalometric parameters for the patient according to the reconstructed volume image data; then use the patient specific cephalometric parameters and population biometry data, to identify one or more maxillofacial/dental abnormalities; and compose patient specific treatment plans to correct selected dentition abnormalities using maxillofacial/dental structure, which can be composed in a final tooth arrangement in a final virtual CT volume. One or more aligners can be generated to incrementally move dentition from the initial arrangement to the final tooth arrangement.

Abstract: The cutting device for the placement of a knee prosthesis includes a bracket and a cutting guide mounted with the ability to move on the bracket. The bracket includes a first marker for identifying it and a fixing element for fixing it to a bone. The cutting guide includes a second marker for identifying it and a slot defining a cutting plane suited to guiding a cutting tool. The invention also relates to an assistance device and to a system having the cutting device. The invention finally relates to an assistance method and to a computer program product and to a data recording medium for executing the method.

Abstract: Drug delivery devices and methods are provided for delivering one or more drugs into a biological tissue. The devices include microneedles that may be separable from the drug delivery devices, control drug release rate and/or direction, or a combination thereof. When the microneedles are separable, a force applied to the drug delivery devices may be effective to penetrate a biological tissue with the microneedles and then to separate the microneedles from the drug delivery devices. The drug delivery devices may be capable of achieving discrete periods of drug release. Methods for delivery drug with microneedles also are provided.

Abstract: A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.

Abstract: Method for automatically assigning numeric labels to teeth in a dental arch map provides a segmented 3D surface image of patient dentition having identified individual teeth and determined tooth position in the dental arch. A tooth contour for the identified teeth is defined. The tooth type is identified as one of incisor, canine, premolar, or molar. A display of the tooth contour is labeled with an assigned tooth number according to the tooth position, tooth contour, and tooth type. The labeled mapping is displayed.

Abstract: Disclosed is a sensor measuring patient spine vertebra angular orientation, including: a fastener, adapted to be fastened on a specific patient spine vertebra in a unique orientation relative to the specific vertebra, a support, solidary with the fastener in a unique orientation relative to the fastener, a detector, removably secured to the support in a unique orientation relative to the support and adapted to measure one or more parameters representative of the patient spine vertebra angular orientation.

Abstract: The devices 400, 500 include microneedles 450, 550 that may be separable from the drug delivery devices, control drug release rate and/or direction, or a combination thereof. When the microneedles are separable, a force applied to the drug delivery devices may be effective to penetrate a biological tissue with the microneedles and then to separate the microneedles from the drug delivery devices. The drug delivery devices may be capable of achieving discrete periods of drug release.

Abstract: Method and/or apparatus embodiments can provide a virtual orthodontic base, adapted to each virtual 3D dental model of the teeth (e.g., upper and lower jaw). The virtual orthodontic base should match each 3D model (e.g., size), conform to prescribed dimensional requirements and still be rapidly calculated. The 3D virtual teeth model can he provided or reconstructed (e.g., from a laser scanning, intra oral camera scanning or x-ray scan of a plaster, a negative impression (e.g., alginate or silicon) of a patient's dentition or directly from the patient's mouth).

Abstract: A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.