Abstract: Apparatus and methods for mitigation and control of inflammatory responses during usage of an implantable sensor device. In one exemplary embodiment, the implantable sensor device includes a drug-eluting component configured to release a varying amount of anti-inflammatory substance(s) (such as corticosteroid) over the lifetime of the implant, such as according to a desired elution profile. In one variant, this component is also an analyte-permeable membrane used as part of a detector of the implant. Inhibition of inflammation in the tissue improves availability of analytes (such as oxygen and glucose) to the sensor in addition to reducing fibrous encapsulation. Various modifications to the elution rate, and configuration of the implant, allow optimized control over undesirable effects such as foreign body reactions (FBR) or other inflammatory responses which may reduce usable implant lifetime.

Abstract: The invention seeks to provide a gasket for a quick connector that is inexpensive to fabricate, providing sealing over a wide range of fluid pressures, while presenting engagement forces that are small for flow diameters of large size. More precisely, the present invention provides a sealing gasket of elastically deformable material having a Y-shaped longitudinal axial section for use in a quick coupling for a fluid duct, the gasket (10) comprising an I-shaped stem (1) and a V-shaped portion (2), flash (3p, 3s) of join plane (P1) of the gasket being located between the I-shaped stem (1) and the V-shaped portion (2), preferably substantially perpendicularly to the longitudinal axis (P2) of the gasket (10). The invention also provides the use of such a gasket, and a mold and a method for fabricating such a gasket.

Abstract: A gasket of multipurpose design is provided, requiring only simple adjustments of the structure of the gasket as a function of the use that is made thereof, namely for connectors in a fluid circuit or for high-pressure hydraulic pistons. More precisely, there is provided an annular gasket of elastically deformable material presenting an axis of revolution and a transverse axis, and comprising, in cross-section, a central zone of determined thickness presenting an inside face facing towards the axis of revolution, and an opposite outside face, together with two side faces interconnecting the inside and outside faces. At least one of the side faces includes at least one compressible lobe; and one of the outside and inside faces carries two lips suitable for bending, that are arranged on either side of the transverse axis, and each of which is connected to a respective one of the side faces.

Abstract: The invention seeks to provide a gasket for a quick connector that is inexpensive to fabricate, providing sealing over a wide range of fluid pressures, while presenting engagement forces that are small for flow diameters of large size. More precisely, the present invention provides a sealing gasket of elastically deformable material having a Y-shaped longitudinal axial section for use in a quick coupling for a fluid duct, the gasket (10) comprising an I-shaped stem (1) and a V-shaped portion (2), flash (3p, 3s) of join plane (P1) of the gasket being located between the I-shaped stem (1) and the V-shaped portion (2), preferably substantially perpendicularly to the longitudinal axis (P2) of the gasket (10). The invention also provides the use of such a gasket, and a mold and a method for fabricating such a gasket.