Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.

Abstract: A system for managing security certificates on a plurality of remote computers comprises a certificate manager that can determine in accordance with at least one preestablished criterion whether a security certificate on a remote computer is to be managed. The system also includes an installer module that can access an account of the remote computer to manage the security certificate. Methods of using the system are also provided.

Abstract: A system and method for generating and/or managing virtual network(s) is provided. The system provides an interface for end-user(s) to create a virtual network (e.g., on-demand). The virtual network comprises a plurality of servers that allow the user to, for example, develop and/or test software, migrate applications, apply tasks and/or troubleshoot scenarios in a simulated, distributed environment. A user can communicate with the system via an interface (e.g., web-based) to create and/or manage the virtual network. Additionally, the system can employ a common infrastructure to facilitate creation and/or management of a variety of virtual deployment configurations. The common infrastructure can be designed, for example, by administrator(s) having knowledge of hardware and/or software available for employment within the virtual network. The system can further provide a load-balancing mechanism to determine and/or distribute workload to computer(s) with available resource(s).

Abstract: The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chorides and ADAM-10 modulators therefrom.