Abstract: This invention relates to methods and materials for multiplexed utilization of collections of functional ligands, particularly to methods and materials for selecting for and/or utilizing particular desirable traits of functional ligands in a multiplexed manner, and more particularly to methods and materials for selecting for and/or utilizing particular structural changes of functional ligands in a multiplexed manner.

Abstract: Disclosed is a pharmaceutical composition useful as an appetite suppressant. Disclosed also is a process for the suppression of appetite and/or for the treatment and/or prevention of obesity.

Abstract: The present disclosure provides aerosol generating substrates and aerosol source members comprising aerosol generating substrates, as well as methods of manufacturing thereof. In an example implementation, an aerosol generating substrate may comprise a fibrous filler material, an aerosol forming material, and a plurality of heat conducting constituents, wherein the substrate is formed as a sheet, and wherein the heat conducting constituents are part of the sheet. The heat conducting constituents may be incorporated within the sheet, or may be formed on a surface of the sheet. In another example implementation, an aerosol source member may comprise a substrate portion formed of a collection of intermingled pieces cut from an aerosol substrate sheet. In addition, or alternatively, a substrate portion may be formed of a series of overlapping layers of an aerosol substrate sheet.

Abstract: An endotracheal tube holder device is provided for securely holding an endotracheal tube to a patient during intubation. The tube holder device includes a support rail placed above a lip of a patient. An auxiliary clip is coupled to the support rail and slidably movable along the length of the support rail for holding an accessory device relative to the patient's face. The auxiliary clip includes both a horizontal accessory holder and a vertical accessory holder to releasably retain the accessory device horizontally and vertically, respectively. A tube fastener is coupled to the support rail and includes a tube holder base, an adjustment clip coupled to the tube bolder base for laterally repositioning the tube holder base along the support rail, and a securement tie. The securement tie may be wrapped around a portion of the endotracheal tube to secure the tube to the tube holder base.

Abstract: The present disclosure generally relates to displaying information related to a physical activity. In some embodiments, methods and user interfaces for managing the display of information related to a physical activity are described.

Abstract: Systems and methods are disclosed that provide smart alerts to users, e.g., alerts to users about diabetic states that are only provided when it makes sense to do so, e.g., when the system can predict or estimate that the user is not already cognitively aware of their current condition, e.g., particularly where the current condition is a diabetic state warranting attention. In this way, the alert or alarm is personalized and made particularly effective for that user. Such systems and methods still alert the user when action is necessary, e.g., a bolus or temporary basal rate change, or provide a response to a missed bolus or a need for correction, but do not alert when action is unnecessary, e.g., if the user is already estimated or predicted to be cognitively aware of the diabetic state warranting attention, or if corrective action was already taken.

Abstract: A location-aware digital betting transaction processing system and method are described, in which open bets involving gaming events are advertised for sale by ticket owners using a digital marketplace that is embedded in or electrically adjacent to a sportsbook platform (e.g., app or website). Ticket buyers and sellers provide their locations or their locations are automatically determined with their permission. Location information may be used by the marketplace and platform system(s) to determine and/or facilitate certain types of buy/sell transactions and for other purposes.

Abstract: Packages of insects are attached to a carrier cylinder and the cylinder is rotated in a radiation field so that the packaged insects are sterilized. The radiation field is created by a plurality of x-ray tubes mounted above the carrier cylinder. The tubes (and their respective radiation sources) are positioned so that a consistent radiation dosage is delivered at the surface of the cylinder—thereby imparting both a precise and uniform dose of radiation to the insect packages affixed to the surface of the cylinder.

Abstract: Methods of depositing a film selectively onto a first material relative to a second material are described. The substrate is pre-cleaned by heating the substrate to a first temperature, cleaning contaminants from the substrate and activating the first surface to promote formation of a self-assembled monolayer (SAM) on the first material. A SAM is formed on the first material by repeated cycles of SAM molecule exposure, heating and reactivation of the first material. A final exposure to the SAM molecules is performed prior to selectively depositing a film on the second material. Apparatus to perform the selective deposition are also described.

Abstract: A method of making an optical article having a gradient tint and a gradient polarization. The method includes providing an optical element including a coating having at least one alignment zone. A dye composition is contacted with the coating. The dye composition includes at least one of: a dichroic dye, a photochromic-dichroic dye, or a combination thereof to diffuse at least a portion of the dye composition into the coating at a predetermined concentration gradient along at least a portion of the coating to provide the gradient tint and the gradient polarization. A kit for making an optical article having a gradient tint and a gradient polarization. An optical article prepared from a method for making an optical article having a gradient tint and a gradient polarization.

Abstract: In embodiments of a thermal and environmental control system an off-grid cold-storage facility has solar photovoltaic panels for producing electricity. A battery is in operable connection with the solar photovoltaic panels and configured to store the electricity produced by the solar photovoltaic panels. Cooling equipment is in operable connection to the battery and configured to regulate the temperature of the off-grid storage facility. Ventilation equipment is in operable connection to the battery to regulate air humidity and gas concentrations. A computer processor is provided at the off-grid storage facility and is in operable connection with the cooling equipment. The computer processor is configured to provide a regulating signal to the cooling equipment for optimizing battery usage, thermal setpoint, and environmental conditions. A cloud-based computing system is in operable communication to weather data and in operable communication to the computer processor.

Abstract: Systems and methods for generating and validating certified electronic credentials are disclosed. A certified electronic credential may comprise a computer-readable file representative of a credential bestowed upon a recipient, in which the file is protected with one or more document integrity and document usage security feature. A publisher may receive a certified electronic credential order from a credentialer and prepare a plurality of certified electronic credentials. The publisher may associate each credential with authentication information and a credential record, and retain a database of associated authentication information and credential records. The publisher may provide validation services, receiving a validation request through a credentialer's validation portal, and provide a response through the credentialer's portal indicative of the validity, additional information about the credential, and even an audit trail.

Abstract: Systems and methods for generating and validating certified electronic credentials are disclosed. A publisher may receive a certified electronic credential order from a credentialer and prepare a plurality of certified electronic credentials. The publisher may associate each credential with authentication information and a credential record, and retain a database of associated authentication information and credential records. The publisher may provide validation services, receiving a validation request through a credentialer's validation portal, and provide a response through the credentialer's portal indicative of the validity, additional information about the credential and/or the credential holder. The credential holder may assign a personal access key to control or limit the validation of a credential. A validating entity may receive credential validation through the credentialer with a heightened degree of confidence in the validation and lack of forgery.

Abstract: An ice bin for a refrigerator appliance, the ice bin includes a storage body. An auger, rotatably driven by an auger motor, extends within the storage body and has first and second ends. The auger is rotatably driven about a first axis. A first crusher roller is disposed at the second end of the auger and is coupled thereto to rotate together with the auger about the first axis. A second crusher roller is disposed on an axle extending along a second axis, the second crusher roller is freely rotatable about the axle. The second crusher roller is movable between a first position and a second position. When the second crusher roller is in the first position, the first crusher roller and the second crusher roller are spatially arranged and configured to grind the produced ice pieces into crushed ice.

Abstract: Methods of improved selectively for SAM-based selective depositions are described. Some of the methods include forming a SAM on a second surface and a carbonized layer on the first surface. The substrate is exposed to an oxygenating agent to remove the carbonized layer from the first surface, and a film is deposited on the first surface over the protected second surface. Some of the methods include overdosing a SAM molecule to form a SAM layer and SAM agglomerates, depositing a film, removing the agglomerates, reforming the SAM layer and redepositing the film.

Abstract: An oil-water fractionation system is positioned within a wellbore on a subsurface end of a production tubing proximate to a production region. The fractionation system includes a permeable hydrophobic media for preferentially conveying an oil-enriched stream (reduced water-cut presence) from the production region into the production tubing, and a permeable oleophobic media for preferentially conveying a water-enriched stream (reduced oil-cut presence) into a second flow path. The permeable hydrophobic media and the permeable oleophobic media are in simultaneous hydraulic communication with the production region. The permeable hydrophobic media is manufactured with a relatively high effective permeability to oil, allowing the oil-enriched stream to flow through the permeable hydrophobic media into the production tubing.

Abstract: A chemically-activated inflow control device. The inflow control device comprises a tubular body configured to be connected in series to joints of sand screen in a wellbore. The tubular body forms a bore that receives a slotted base pipe. At the same time, the tubular body is fluidly connected with the sand screen joints, forming an annular flow path between the slotted base pipe and surrounding sand screen. Production fluids moving into the sand screen pass across a component that degrades in the presence of water. If the well begins producing water, the degradable component will dissolve, activating a sealing mechanism within the inflow control device and closing a restricted flow path. In this way, production fluids are not able to travel from the annular flow path into the bore of the slotted base pipe. A method for completing a wellbore having a chemically-activated inflow control device is also provided.

Abstract: The bio sensor platform is a rapid point-of-care (POC) device wherein detection of a target analyte from a liquid or solid substrate is performed in a single step using a fully integrated disposable test system that includes a test strip immunoassay. In operation, a user initiates the test by rupturing the bottom of a liquid-filled analyte capsule seated in a capsule sleeve. A small volume of liquid flows by capillary action from the capsule sleeve and through a restrictor port to a test strip chamber where contact with the absorptive sample pad of the test strip (among other things) moves liquid by capillary action upwardly through the test strip. The detection of the target analyte is resolved by the test strip reagents and the test results are obtained at a test result window where a portion of the test strip is exposed to the user.

Abstract: Systems and methods for generating and validating certified electronic credentials are disclosed. A publisher may receive a certified electronic credential order from a credentialer and prepare a plurality of certified electronic credentials. The publisher may associate each credential with authentication information and a credential record, and retain a database of associated authentication information and credential records. The publisher may provide validation services, receiving a validation request through a credentialer's validation portal, and provide a response through the credentialer's portal indicative of the validity, additional information about the credential and/or the credential holder. The credential holder may assign a personal access key to control or limit the validation of a credential. A validating entity may receive credential validation through the credentialer with a heightened degree of confidence in the validation and lack of forgery.