Patents by Inventor S. James Adelstein

S. James Adelstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for radioisotopic detection and localization of inflammation in a host
    Patent number: 5811073
    Abstract: A method for detecting and localizing the lesions of bacterial and sterile inflammations in a host is disclosed. The method permits in vivo detection and localization of inflammation within 1 to 2 hours of the administration of a radiopharmaceutical agent to the host according to the method of the invention. The radiopharmaceutical agents for use in the method are nucleosides and nucleotides labeled with a radioisotope. The radioisotopes for use in the radiopharmaceutical agents are gamma emitters (preferably halogen gamma emitters) and positron emitters. The radiopharmaceutical agents are administered by parenteral routes, preferably in a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: June 19, 1995
    Date of Patent: September 22, 1998
    Assignee: President and Fellows of Harvard College
    Inventors: Amin I. Kassis, S. James Adelstein
  • Rapid synthesis of radiolabeled pyrimidine nucleosides or nucleotides from stannyl precursors
    Patent number: 5720935
    Abstract: A method of making a radiolabeled pyrimidine nucleoside or nucleotide is described. In the method, a stannylated pyrimidine nucleoside or nucleotide is contacted in an aqueous solution with a radioactive iodide, bromide, chlorine or astatine ion in the presence of an acidic hydrogen peroxide oxidizing solution comprising at least a 3:1 ratio of 30% hydrogen peroxide to 1N acid (v/v), whereby a water soluble pyrimidine nucleoside or nucleotide labeled with radioactive iodine, bromine, chlorine or astatine is formed. Kits suitable for practicing the method are also disclosed.
    Type: Grant
    Filed: June 9, 1995
    Date of Patent: February 24, 1998
    Assignee: President & Fellows of Harvard College
    Inventors: Amin I. Kassis, Catherine F. Foulon, S. James Adelstein
  • Rapid synthesis of radiolabeled pyrimidine nucleosides or nucleotides
    Patent number: 5574148
    Abstract: A method of making a radiolabeled pyrimidine nucleoside or nucleotide is described. In the method an aqueous solution (i) a radioactive iodide, bromide, chlorine or astatide ion and (ii) a water soluble halomercuri pyrimidine nucleoside or nucleotide is contacted with an oxidizing agent, whereby a water soluble pyrimidine nucleoside or nucleotide labeled with radioactive iodine, bromine, chlorine or astatine is formed. Kits suitable for practicing the method are also disclosed.
    Type: Grant
    Filed: February 2, 1995
    Date of Patent: November 12, 1996
    Assignee: President U Fellows of Harvard College
    Inventors: Amin I. Kassis, Catherine F. Foulon, S. James Adelstein
  • Diagnosis of tumors with 5-radioiodo-2'-deoxyuridine
    Patent number: 5308605
    Abstract: A method or the treatment and diagnosis of tumors is disclosed. This method comprises the administration of an effective amount of a radiohalogenated pyrimidine nucleoside to the tumor affected site.
    Type: Grant
    Filed: August 27, 1992
    Date of Patent: May 3, 1994
    Assignee: The President and Fellows of Harvard College
    Inventors: Amin I. Kassis, S. James Adelstein
  • Diagnosis of tumors with 5-(.sup.123 I)iodo-2'-deoxyuridine
    Patent number: 5094835
    Abstract: A method for the treatment and diagnosis of tumors is disclosed. This method comprises the direct administration of an effective anti-tumor amount of a radiohalogenated pyrimidine nucleoside such as .sup.123 IUdR to the affected site.
    Type: Grant
    Filed: February 7, 1991
    Date of Patent: March 10, 1992
    Assignee: The President and Fellows of Harvard College
    Inventors: Amin I. Kassis, S. James Adelstein
  • Treatment of tumors with 5-radioiodo-2'-deoxyuridine
    Patent number: 5077034
    Abstract: A method for the treatment and diagnosis of tumors is disclosed. This method comprises the direct administration of an effective anti-tumor amount of a radiohalogenated pyrimidine nucleoside such as .sup.123 IUdR or .sup.125 IUdR to the affected site.
    Type: Grant
    Filed: March 30, 1990
    Date of Patent: December 31, 1991
    Assignee: The President and Fellows of Harvard College
    Inventors: Amin L. Kassis, S. James Adelstein