Abstract: In one aspect, the disclosure relates to a super high frequency (SHF) or extremely high frequency (EHF) bulk acoustic resonator that includes a nanostructure, wherein the nanostructure includes a substrate, a three-dimensional structure disposed on the substrate, wherein the three-dimensional structure includes a planar structure including at least one nanocomponent and a matrix material contacting the nanocomponent on at least one side, the matrix material including an SiGe alloy or Ge. The disclosed bulk acoustic resonator operates at frequencies of from about 100 MHz to about 100 GHz, is capable of self-amplification upon application of direct current or voltage, and has a Q factor amplification exceeding 1. Also disclosed are methods for amplification of mechanical resonance in the disclosed bulk acoustic resonators and devices incorporating the bulk acoustic resonators.

Abstract: Described herein are compounds that act as antimicrobial agents, compositions comprising these compounds, and methods of their use in to treating infections caused by Helicobacter pylori (H. pylori) or killing or inhibiting the growth of H. pylori.

Abstract: Provided herein are IgE-binding VHH domains, polypeptides, and proteins, and methods of using such IgE-binding polypeptides and proteins to modulate the biological activity of IgE.

Abstract: Provided herein are polypeptides comprising at least one VHH domain that binds ?? TCR and a modified IL-2. Uses of the polypeptides are also provided.

Abstract: A sewer cleaning machine includes a frame, a drum supported by the frame, and a motor supported by the frame and coupled to the drum. The drum includes a cable that is selectively extendable out of the drum. The motor is operable to rotate the drum. The frame is moveable between a first position, in which the drum is supported by the frame off of a surface, and a second position, in which the drum contacts the surface.

Abstract: The present disclosure relates to containers and methods of making same for oral products made or derived from tobacco, incorporate tobacco, or may be tobacco-free and are intended for human consumption. The disclosed containers incorporate one or more of an alignment mechanism, a seal arrangement, a retention mechanism, or a tamper-evident feature to suit a particular application.

Abstract: The present disclosure presents a general approach to engineering existing protein-protein interactions through domain addition and evolution. The disclosure teaches the creation of novel fusion proteins that include knottin peptides where a portion of the knottin peptide is replaced with a sequence that has been created for binding to a particular target. Such fusion proteins can also be bispecific or multi specific in that they can bind to and/or inhibit two or more receptors or receptor ligands. Knottins may be fused with an existing ligand (or receptor) as a general platform tor increasing the affinity of a ligand-receptor interaction or for creating a multi specific protein. In addition, the fusion proteins may comprise a knottin peptide fused to another protein where the other protein facilitates proper expression and folding of the knottin.

Abstract: Provided herein are VHH-containing polypeptides that bind ?? T-cells. Uses of the VHH-containing polypeptides are also provided.

Abstract: Smart surveillance data processing systems support safe uncrewed aircraft system (UAS) or uncrewed surface vessels/vehicles operations where remote pilots are operating their uncrewed aircraft beyond visual line of sight (BVLOS) or near controlled areas, by providing: (i) real-time situational awareness in dense crewed aircraft and uncrewed drone environments while providing automated detection and alerting of intruders to remote pilots in command; (ii) surveillance network performance assessments through radar and ADS-B quantifiable measures; (iii) detection and alerting of any appreciable degradation of surveillance sensor performance, allowing remote pilots to suspend or alter operations to ensure safety; (iv), standardized airspace reporting including traffic patterns; (v) certification of portions of the airspace where the surveillance network is capable of meeting a minimum standard; (vi) assessment and reporting of drone compliance and non-compliance with UAS operating regulations.

Abstract: The present invention relates to a composition such as an anhydrous gel, and its use for example as a cosmetic base, comprising a silicone-based excipient and one or more carrier oils, and methods of administering the composition to a subject.

Abstract: In one aspect, an optical system is disclosed, which includes a light guide having an input end for receiving light from at least one light source and an output end through which light exits the light guide, said light guide further having at least one highly reflective surface positioned to provide specular reflection of at least a portion of the light entering via the input end of the light guide, where the highly reflective surface exhibits a specular reflectance of at least about 95% for light with one or more wavelengths in a wavelength range of about 380 nm to about 780 nm.

Abstract: Provided herein are IgE-binding VHH domains, polypeptides, and proteins, and methods of using such IgE-binding polypeptides and proteins to modulate the biological activity of IgE.

Abstract: Provided herein are VHH-containing polypeptides that bind CD33. Uses of the VHH-containing polypeptides are also provided.

Abstract: This invention relates generally to molecules that specifically engage OX40, a member of the TNF receptor superfamily (TNFRSF). More specifically this invention relates to multivalent and multispecific molecules that bind at least OX40.

Abstract: Provided herein are IgE-binding VHH domains, polypeptides, and proteins, and methods of using such IgE-binding polypeptides and proteins to modulate the biological activity of IgE.

Abstract: The invention relates generally to multispecific polypeptides that bind at least CD3, a second antigen, and a receptor of a T cell, such as a costimulatory receptor or an inhibitory receptor, in which the multispecific polypeptide constructs are able to engage CD3. In some embodiments, the multispecific polypeptide constructs bind a costimulatory receptor and provide costimulatory binding activity. In some embodiments, the multispecific polypeptide constructs bind an inhibitory receptor and block inhibitory activity. In some aspects, the multispecific polypeptides have constrained CD3 binding and bind to or engage CD3 only upon binding to the second antigen, such as a tumor associated antigen. In some embodiments, the multispecific polypeptides contain cleavable linkers that, when cleaved, result in dual effector functions. Also provided are methods of making and using these multispecific polypeptides in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: This invention relates generally to molecules that specifically engage 41BB, a member of the TNF receptor superfamily (TNFRSF). More specifically, this invention relates to multivalent and multispecific molecules that bind at least 41BB.

Abstract: In one aspect, a light pipe is disclosed. In some embodiments, the light pipe comprises an input section including a waveguide having a circular cross section; and an output section having a polygonal cross section, wherein the input section has an input surface for receiving light from one or more light sources and an output surface through which light exits the input section, and the output section has an input surface optically coupled to the output surface of the input section to receive at least a portion of the light exiting the input section, and an output surface through which light exits the light pipe.

Abstract: In one aspect, an optical system for delivering light into an optical fiber is disclosed, which comprises a phosphor-converted white light source for generating white light, a red light emitting diode (LED) for generating red light, and a light-delivery system for delivering at least a portion of said white light and said red light into an input port of an optical fiber.

Abstract: A method of stabilizing a first vertebra and a second vertebra includes implanting a first bone anchor into the first vertebra, implanting a second bone anchor into the second vertebra, connecting a first anchor connection instrument to the first anchor, connecting a second anchor connection instrument the second anchor, positioning a cement delivery tube into a passage provided through the first anchor, delivering bone cement from a bone cement delivery system coupled to the bone cement delivery tube through the passage in the first anchor to the first vertebra, removing the cement delivery tube from the first anchor connection instrument and the first anchor, connecting the cement delivery tube to second anchor connecting instrument connected to the second anchor, delivering bone cement through a passage in the second anchor to the second vertebra, connecting a spinal connection element to the first anchor and the second anchor.