Abstract: Disclosed are compounds of formula I as described herein, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of plasma kallikrein. Also provided are pharmaceutical compositions comprising at least one compound of the invention, and methods involving use of the compounds and compositions of the invention in the treatment and prevention of diseases and conditions characterized by unwanted plasma kallikrein activity.

Abstract: Disclosed are compounds of formula I as described herein, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of plasma kallikrein. Also provided are pharmaceutical compositions comprising at least one compound of the invention, and methods involving use of the compounds and compositions of the invention in the treatment and prevention of diseases and conditions characterized by unwanted plasma kallikrein activity.

Abstract: Apparatus and methods for a prosthetic heart valve are provided. The apparatus may include a prosthetic heart-valve fitting. The fitting may be seated in a valve annulus of the heart. The fitting may be a fitting that does not include a tissue-penetrating anchor. The fitting may be a fitting that does not include a tissue-penetrating barb. The apparatus may include a brace. The brace may be urged by an atrial tissue of the heart to maintain a position of the fitting in the annulus.

Abstract: The present invention generally relates to a water purification device designed to operate primarily on gravitational force. The device comprises an inlet chamber (102) for storing surface water; and a filtration chamber (104) placed beneath the inlet chamber housing: a first filter made up of a 1:3 mixture of zeolite and acid-fractionalized activated charcoal, supported on a cotton bed; a second filter (104B) consisting of powdered eggshell membrane mixed with zeolite and Fe3O4 nanoparticles in a 5:3:1 ratio; and a third filter (104C) composed of a mixture of eggshell membrane powder, zeolite, Fe3O4, and AgNO3 nanoparticles, all supported on a cotton bed in a 5:3:1:1 ratio; and an outlet (106) adjusted at a bottom section for collecting purified water. The surface water enters from a top of the filtration chamber and is subjected to gravitational force, leading it through the series of filters towards the outlet.

Abstract: An electronic device comprising a lower deck and an upper deck adjacent to a source. Each of the lower deck and the upper deck comprise tiers of alternating conductive materials and dielectric materials. Each of the lower deck and the upper deck also comprise an array region and one or more non-array regions. Memory pillars are in the lower deck and the upper deck of the array region and the memory pillars are configured to be operably coupled to the source. Dummy pillars are in the upper deck of the one or more non-array regions and the dummy pillars are configured to be electrically isolated from the source. Another conductive material is in the upper deck and the lower deck of the one or more non-array regions. Additional electronic devices and related systems and methods of forming an electronic device are also disclosed.

Abstract: Embodiments of delivery systems, devices and methods for delivering a prosthetic heart valve device to a heart chamber for expanded implementation are disclosed. More specifically, methods, systems and devices are disclosed for delivering a self-expanding prosthetic mitral valve device to the left atrium, with no engagement of the left ventricle, the native mitral valve leaflets or the annular tissue downstream of the upper annular surface during delivery, and in some embodiments with no engagement of the ventricle, mitral valve leaflets and/or annular tissue located downstream of the upper annular surface by the delivered, positioned and expanded prosthetic mitral valve device.

Abstract: Techniques are disclosed relating to memory error tracking and logging. In some embodiments, a memory cache controller circuitry is configured to track, using multiple circuit entries, numbers of detected correctable errors associated with multiple respective locations, and in response to detecting a threshold number of correctable errors for a particular location, generate a signal to the one or more processors that identifies the particular location. In some embodiments, the memory cache controller circuitry includes multiple circuit entries for tracking uncorrectable errors.

Abstract: Methods, apparatus, and processor-readable storage media for automated database operation classification using artificial intelligence techniques are provided herein. An example computer-implemented method includes obtaining at least one query related to one or more database operations; obtaining information pertaining to a set of multiple storage resources; classifying the at least one query as associated with at least one of multiple subsets of storage resources among the set of multiple storage resources by processing at least a portion of the query and at least a portion of the information pertaining to the set of multiple storage resources using one or more artificial intelligence techniques; and performing one or more automated actions based at least in part on the classifying of the at least one query.

Abstract: A diesel exhaust fluid (DEF) nozzle includes a first conduit, an outlet of the first conduit defining an inlet of a first mixing chamber; and a second conduit disposed around the first conduit, an outer surface of the first conduit and an inner surface of the second conduit defining a second flow path therebetween. A flow area of the second flow path decreases from an inlet of the second flow path to a throat, and increases from the throat to an outlet of the second flow path. The inner surface of the second conduit defines a peripheral wall of the first mixing chamber, and a peripheral wall of a second mixing chamber, the first flow path and the second flow path being in fluid communication with the second mixing chamber via the first mixing chamber.

Abstract: An aircraft includes a gas turbine engine, an electric motor, and a propulsion device. The gas turbine engine and the electric motor are configured to provide a target cumulative output to the propulsion device. An electronic control unit is configured to set the gas turbine engine to a first engine mode to provide a first engine output to the propulsion device, set the electric motor to a first motor mode to provide a first motor output to the propulsion device, a sum of the first engine output and the first motor output being within a predetermined range of the target cumulative output, and in response to a speed of the aircraft reaching a target speed and the first engine output increasing to a second engine output, set the electric motor to a second motor mode.

Abstract: Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein A, G, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Abstract: Embodiments of the present disclosure relate to systems, methods, and user interfaces for providing voice-activated ambulance booking. Initially, a non-medical user initiates a workflow, via a voice command, that enables the user to provide information about a patient that can be utilized to prioritize the booking of ambulances for patients. Upon providing the initial voice command, the workflow is provided, via a user interface of the user device. The workflow comprises a series of questions corresponding to a status of the patient that can easily be answered merely by observing the patient (e.g., is the patient conscious, is the patient breathing, is the patient bleeding). Based on responses provided by the user, an ambulance is requested for the patient. User device vitals including battery charge levels and signal strength can be used to resolve conflicts if multiple requests are made.

Abstract: Techniques are disclosed for data management in an information processing system. For example, a method comprises analyzing one or more data sources, wherein each of the one or more data sources comprise a set of metadata and usage information associated with the set of metadata. The method then determines at least one of data definitions and data classifications for the one or more sets of metadata across the one or more data sources, and stores the at least one of data definitions and data classifications for the one or more sets of metadata in a repository.

Abstract: Techniques and mechanisms for improving an efficiency of power delivery resources. In one embodiment, switch circuitry is operated based on an indication from an integrated circuit (IC) die that circuitry of the IC die is ready to accommodate a low power state which disables a delivery of power to the IC die by a voltage regulator (VR). The switch circuitry is operated, based on a control signal is also used to disable said power delivery, to disable or otherwise prevent one or more conductive paths which are each between a respective two of a battery pack, a voltage regulator, or a battery charger. In another embodiment, the low power state enable a rail for circuitry which is to provide a real time clock signal to the IC die, but disables any other rails which power the IC die.

Abstract: Techniques are disclosed for domain-driven intent-based feedback data analysis. For example, a method comprises obtaining a feedback data set, and classifying the feedback data set into at least one domain of a plurality of domains. The feedback data set is mapped to a domain data set corresponding to the at least one domain, and a root cause is computed for the feedback data set to enable one or more actions to be taken in response to the feedback data set based on the root cause. By way of further example, computing the root cause for the feedback data set may further comprise utilizing at least one computed intent attribute, at least one computed sentiment attribute, and the domain data set to compute a decision on the root cause for the feedback data set.

Abstract: Methods, apparatus, and processor-readable storage media for automated database operation classification using artificial intelligence techniques are provided herein. An example computer-implemented method includes obtaining at least one query related to one or more database operations; obtaining information pertaining to a set of multiple storage resources; classifying the at least one query as associated with at least one of multiple subsets of storage resources among the set of multiple storage resources by processing at least a portion of the query and at least a portion of the information pertaining to the set of multiple storage resources using one or more artificial intelligence techniques; and performing one or more automated actions based at least in part on the classifying of the at least one query.

Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.