Patents by Inventor S. Mariana Margarit

S. Mariana Margarit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystal of a Ras-Sos complex and methods of use thereof
    Patent number: 6156526
    Abstract: A detailed three-dimensional structure for the complex formed between Ras and the Son of sevenless (Sos) protein is provided. Crystals of this complex are also included in the invention. The present invention farther provides procedures for identifying agents that can inhibit tumor proliferation through the use of rational drug design predicated on the crystals and crystallographic data disclosed.
    Type: Grant
    Filed: July 21, 1998
    Date of Patent: December 5, 2000
    Assignees: The Rockerfeller University, The Research Foundation of State University of New York
    Inventors: Ann Boriack-Sjodin, S. Mariana Margarit, Dafna Bar-Sagi, Philip Cole, John Kuriyan
  • Crystal of a Ras-Sos complex
    Patent number: 6117663
    Abstract: A detailed three-dimensional structure for the complex formed between Ras and the Son of sevenless (Sos) protein is provided. Crystals of this complex are also included in the invention. The present invention further provides procedures for identifying agents that can inhibit tumor proliferation through the use of rational drug design predicated on the crystals and crystallographic data disclosed.
    Type: Grant
    Filed: July 19, 1999
    Date of Patent: September 12, 2000
    Assignees: The Rockefeller University, The Research Foundation of State University of New York
    Inventors: Ann Boriack-Sjodin, S. Mariana Margarit, Dafna Bar-Sagi, Philip Cole, John Kuriyan