Patents by Inventor S. Morris Kupchan

S. Morris Kupchan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4164584
    Abstract: There are provided novel anti-leukemic epoxides which are isolated from Baccharis megapotamica. The novel compounds are characterized by a 12,13-epoxytrichothecene central ring system which is spanned by a dienic macrolide ester side chain. The active compounds are characterized by the presence of an oxygen atom in the A-ring which takes the form of either a beta hydroxy group in the 8 position together with an unsaturated bond at the 9: 10 position or, alternatively, an epoxide group lying between the 9 and 10 position. Compounds devoid of either of these groups show no anti-leukemic activity.The active compounds possess high and surprising anti-leukemic activity against P-388 lymphocytic leukemia in in vivo assays in mice.
    Type: Grant
    Filed: October 25, 1977
    Date of Patent: August 14, 1979
    Assignee: Research Corporation
    Inventors: S. Morris Kupchan, deceased, Bruce B. Jarvis, Richard G. Dailey, Jr.
  • Patent number: 4013664
    Abstract: There is disclosed a novel and improved method of synthesizing aporphines utilizing the Pschorr cyclization of 1-(2'-aminobenzyl)-7 hydroxy-1,2,3,4-tetrahydroisoquinolines in place of the corresponding 7-methoxy compounds.In the novel process of the present invention the amino group is diazotized and cyclized in the presence of copper powder.
    Type: Grant
    Filed: June 20, 1973
    Date of Patent: March 22, 1977
    Assignee: Research Corporation
    Inventors: S. Morris Kupchan, Venkataraman Kameswaran
  • Patent number: 4005108
    Abstract: There are provided novel diterpenoid triepoxides, derived from Tripterygium wilfordii Hook F. which possess high and surprising antileukemic activity at dosage levels of micrograms/kilogram body weight.
    Type: Grant
    Filed: April 3, 1973
    Date of Patent: January 25, 1977
    Assignee: Research Corporation
    Inventors: S. Morris Kupchan, William A. Court
  • Patent number: 3976652
    Abstract: There is disclosed a novel total synthesis of Thalicarpine which includes inter alia a total synthesis of hernandaline. The novel process is characterized in utilizing simple and readily available starting materials to form a diaryl ether system which is then condensed with a 3,4-dihydroisoquinolinium salt which is then converted to hernandaline. Hernandaline is reacted with a bicyclic Reissert compound to yield a compound having the thalicarpine skeleton, nascent hydrogen reduction yields N-monodesmethyl thalicarpine which is methylated.
    Type: Grant
    Filed: May 8, 1974
    Date of Patent: August 24, 1976
    Assignee: Research Corporation
    Inventors: S. Morris Kupchan, Andris J. Liepa
  • Patent number: 3969369
    Abstract: There is provided a novel simaroubolide derived from Brucea antidysenterica which possesses high and surprising anti-leukemic activity at dosage levels of micrograms per kilogram body weight.
    Type: Grant
    Filed: June 20, 1973
    Date of Patent: July 13, 1976
    Assignee: Research Corporation
    Inventors: S. Morris Kupchan, Ronald W. Britton