Patents by Inventor S. Narasimhan Danthi

S. Narasimhan Danthi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small molecules for imaging protein-protein interactions
    Patent number: 7943775
    Abstract: A tissue is imaged to detect the presence of amyloid deposits or other target proteins prior to their aggregation into plaques, with the assistance of the administration of a labeled bifunctional compound of which one functionality binds to the target protein and the second functionality binds to a chaperone protein that is present in the tissue of interest. The two functionalities have different binding affinities, the target-binding functionality having the greater binding affinity, with the result that the bifunctional compound preferentially remains in the tissue when bound to the chaperone and then the target protein while bifunctional compound that is not bound to the target protein will leave the tissue.
    Type: Grant
    Filed: June 13, 2007
    Date of Patent: May 17, 2011
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: King C. Li, S. Narasimhan Danthi
  • Integrin ?-v ?-3 antagonists for use in imaging and therapy
    Patent number: 7300940
    Abstract: Integrin receptor antagonists whose molecular structure includes a tetrahydropyridimidinylaminoethyloxybenzoyl group on a sulfonylamino-?-alanine nucleus exhibit increased binding affinity for the ?v?3 receptor when further substituted on the sulfonyl moiety with an N-amino alkycarbamyl group or a butyloxycarbonylamino alkylcarbamoyl group or similar groups.
    Type: Grant
    Filed: August 4, 2004
    Date of Patent: November 27, 2007
    Assignee: The United States of America, as represented by the Secretary of the Department of Health and Human Services
    Inventors: S. Narasimhan Danthi, King C. Li, Christopher A. Burnett
  • Targeted multivalent macromolecules
    Publication number: 20030133972
    Abstract: Targeted macromolecules comprising a linking carrier and more than one targeting entity are provided, as well as methods for their preparation and use.
    Type: Application
    Filed: May 30, 2002
    Publication date: July 17, 2003
    Applicant: TARGESOME, INC.
    Inventors: S. Narasimhan Danthi, Mark David Bednarski, Charles Aaron Wartchow, Hoyul Steven Choi
  • Targeted multivalent macromolecules
    Publication number: 20030129223
    Abstract: Targeted therapeutic agents, comprising a linking carrier, a therapeutic entity associated with the linking carrier, and at least one targeting entity are provided, as well as methods for their preparation and use.
    Type: Application
    Filed: May 30, 2002
    Publication date: July 10, 2003
    Applicant: TARGESOME, INC.
    Inventors: Charles Aaron Wartchow, Neal Edward DeChene, John S. Pease, Zhimin Shen, Julie Trulson, Mark David Bednarski, S. Narasimhan Danthi, Michael Zhang, Hoyul Steven Choi