Patents by Inventor Sándor Mahó

Sándor Mahó has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210115084
    Abstract: The invention relates to the last step of a synthetic process, in which Nomegestrol-acetate of formula (I) is synthesized from 17?-acetoxy-6-methylene-19-norpregn-4-ene-3,20-dione of formula (II) in the presence of Pd/C catalyst and acetic acid in hot ethanolic solution.
    Type: Application
    Filed: December 15, 2017
    Publication date: April 22, 2021
    Inventors: Sándor MAHÓ, János CSÖRGEI, Csaba SÁNTA, Péter VINCZE, László BALOGH, János HORVÁTH, Zoltán BÉNI
  • Patent number: 9683010
    Abstract: The present invention relates to a process for the synthesis of compounds of formula (I), wherein the meaning of R is dimethylamino or acetyl group, using the compound of formula (III) or (IV), wherein the meaning of R? is dimethylamino or 2-methyl-1,3-dioxan-2-yl group, as starting material and methoxymethyl lithium as reagent.
    Type: Grant
    Filed: February 16, 2015
    Date of Patent: June 20, 2017
    Assignee: Richter Gedeon Nyrt.
    Inventors: Sándor Mahó, Csaba Sánta, János Csörgei, Gábor Szabó, Tamás Schäfer, Zoltán Béni
  • Patent number: 9676814
    Abstract: The present invention relates to a new process for the synthesis of compounds of formula (I) (wherein the meaning of R is dimethylamino or acetyl group) using the compound of formula (II) (wherein the meaning of R is dimethylamino or 2-methyl-1,3-dioxolan-2-yl group) as starting material, as well as to the intermediate of the process.
    Type: Grant
    Filed: October 1, 2014
    Date of Patent: June 13, 2017
    Assignee: RICHTER GEDEON NYRT.
    Inventors: Sándor Mahó, Csaba Sánta, János Csörgei, János Horváth, Antal Aranyi, Zoltán Béni
  • Patent number: 9562067
    Abstract: The present invention relates to a new stereoselective process for the synthesis of 17(?)-17-acetyl-17-hydroxy-estr-4-en-3-one of formula (I), as well as to the new intermediates of the process. The 17(?)-17-acetyl-17-hydroxy-estr-4-en-3-one (gestonorone) is an important intermediate in the synthesis of the active ingredients having progestogen activity—such as gestonorone capronate and nomegestroi acetate. Formulas (I), (II) and (III).
    Type: Grant
    Filed: December 15, 2014
    Date of Patent: February 7, 2017
    Assignee: RICHTER GEDEON NYRT.
    Inventors: János Csörgei, Anita Horváth, Csaba Sánta, Sándor Mahó, Zoltán Béni, János Horváth
  • Publication number: 20160326211
    Abstract: The present invention relates to a process for the synthesis of compounds of formula (I), wherein the meaning of R is dimethylamino or acetyl group, using the compound of formula (III) or (IV), wherein the meaning of R? is dimethylamino or 2-methyl-1,3-dioxan-2-yl group, as starting material and methoxymethyl lithium as reagent.
    Type: Application
    Filed: February 16, 2015
    Publication date: November 10, 2016
    Inventors: Sándor MAHÓ, Csaba SÁNTA, János CSÖRGEI, Gábor SZABÓ, Tamás SCHÄFER, Zoltán BÉNI
  • Publication number: 20160311849
    Abstract: The present invention relates to a new process for the synthesis of compounds of formula (I) (wherein the meaning of R is dimethylamino or acetyl group) using the compound of formula (II) (wherein the meaning of R is dimethylamino or 2-methyl-1,3-dioxolan-2-yl group) as starting material, as well as to the intermediate of the process.
    Type: Application
    Filed: October 1, 2014
    Publication date: October 27, 2016
    Applicant: RICHTER GEDEON NYRT.
    Inventors: Sándor MAHÓ, Csaba SÁNTA, János CSÖRGEI, János HORVÁTH, Antal ARANYI, Zoltán BÉNI
  • Publication number: 20160297848
    Abstract: The present invention relates to a new stereoselective process for the synthesis of 17(?)-17-acetyl-17-hydroxy-estr-4-en-3-one of formula (I), as well as to the new intermediates of the process. The 17(?)-17-acetyl-17-hydroxy-estr-4-en-3-one (gestonorone) is an important intermediate in the synthesis of the active ingredients having progestogen activity—such as gestonorone capronate and nomegestroi acetate. Formulas (I), (II) and (III).
    Type: Application
    Filed: December 15, 2014
    Publication date: October 13, 2016
    Inventors: János CSÖRGEI, Anita HORVÁTH, Csaba SÁNTA, Sándor MAHÓ, Zoltán BÉNI, János HORVÁTH
  • Patent number: 8513228
    Abstract: The present invention relates to novel crystalline Form A of 17?-acetoxy-21-methoxy-11?-[4-N,N-dimethylaminophenyl]-19-norpregna-4,9-diene-3,20-dione, (also known as CDB-4124) and methods for the preparation of it in excellent purity.
    Type: Grant
    Filed: March 22, 2010
    Date of Patent: August 20, 2013
    Assignee: Richter Gedeon Nyrt.
    Inventors: Csaba Santa, Adam Demeter, Balazs Havasi, Sandor Maho
  • Patent number: 8450476
    Abstract: The invention relates to a process for the preparation of 17-hydroxy-6?,7?;15?,16?-bismethylene-17?-pregn-4-ene-3-one-21-carboxylic acid ?-lactone of formula (I) as well as to key-intermediates for this process.
    Type: Grant
    Filed: October 11, 2005
    Date of Patent: May 28, 2013
    Assignee: Richter Gedeon Nyrt.
    Inventors: György Gálik, Judit Horváth, Béla Sörös, Sándor Mahö, Zoltán Tuba, Gábor Balogh
  • Patent number: 8314145
    Abstract: The invention relates to a new process for the synthesis of high purity 17?-cyanomethyl-17?-hydroxy-estra-4,9-diene-3-one (further on dienogest) of formula (I) from 3-methoxy-17-hydroxy-estra-2,5(10)-diene of formula (V). The invention relates also to the high purity 17?-cyanomethyl-17?-hydroxy-estra-4,9-diene-3-one and pharmaceutical compositions containing that as active ingredient. The pharmaceutical compositions according to this invention contain high purity dienogest of formula (I) in which the total amount of impurities is less than 0.1%, while the amount of 4-bromo-dienogest is under the detection limit (0.02%) as active ingredient or at least one of the active ingredients and auxiliary materials, which are commonly used in practice, such as carriers, excipients or diluents.
    Type: Grant
    Filed: October 11, 2006
    Date of Patent: November 20, 2012
    Assignee: Richter Gedeon Vegyeszeti Gyar RT
    Inventors: Lajosné Dancsi, Sándor Mahó, Antal Aranyi, János Horváth
  • Patent number: 8309712
    Abstract: The invention relates to an industrial process for the preparation of 17-hydroxy-6?,7?;15?,16?-bismethylene-3-oxo-17?-pregn-4-ene-21-carboxylic acid ?-lactone of formula (I), and to the key-intermediates for this process.
    Type: Grant
    Filed: October 11, 2005
    Date of Patent: November 13, 2012
    Assignee: Richter Gedeon Nyrt.
    Inventors: Béla Sörös, Judit Horváth, György Gálik, József Bódi, Zoltán Tuba, Sándor Mahó, Gábor Balogh, Antal Aranyi
  • Patent number: 8183402
    Abstract: The present invention relates to a process for the synthesis of the 17-acetoxy-11?-[4-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione of formula (I): from 3,3-[1,2-etandiyl-bis(oxy)]-oestr-5(10),9(11)-dien-17-one of formula (II):
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: May 22, 2012
    Assignee: Richter Gedeon Nyrt.
    Inventors: József Bódi, György Visky, János Széles, Sándor Mahó, Csaba Sánta, János Csörgei, Zoltán Tuba, László Terdy, Csaba Molnár, Antal Aranyi, Zoltán Horváth, Gábor Balogh
  • Publication number: 20120077791
    Abstract: The present invention relates to novel crystalline Form A of 17?-acetoxy-21-methoxy-11?-[4-N,N-dimethylaminophenyl]-19-norpregna-4,9-diene-3,20-dione, (also known as CDB-4124) and methods for the preparation of it in excellent purity.
    Type: Application
    Filed: March 22, 2010
    Publication date: March 29, 2012
    Inventors: Csaba Santa, Adam Demeter, Balazs Havasi, Sandor Maho
  • Patent number: 7816546
    Abstract: The invention relates to a process for the synthesis of d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-oxime (also known as norelgestromin) via acetylation of d-norgestrel at position 17; oximation of the oxo group at position 3 of the obtained d-(17?)-13-ethyl-17-(acetyloxy)-18,19-dinorpregn-4-ene-20-yn-3-one; and then hydrolyzing the acetyloxy group at position 17 of the obtained d-(17?)-13-ethyl-17-(acetyloxy)-18,19-dinorpregn-4-ene-20-yn-3-oxime derivative, thereby obtaining norelgestromin.
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: October 19, 2010
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Zoltán Tuba, Sándor Mahó, János Kiss, Endréné Magyari, László Terdy
  • Publication number: 20100137622
    Abstract: The present invention relates to a process for the synthesis of the known 17-acetoxy-11-?-[4-(dimethyl amino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione (further on CDB-4124) of formula (I) from 3,3-[1,2-ethandiyl-bis(oxy)]-oestr-5(10),9(11)-dien-17-one of formula (II). Compound CDB-4124 belongs to the group of anti-hormones.
    Type: Application
    Filed: June 19, 2008
    Publication date: June 3, 2010
    Inventors: József Bódi, György Visky, János Széles, Sándor Mahó, Csaba Sánta, János Csörgei, Zoltán Tuba, László Terdy, Csaba Molnár, Antal Aranyi, Zoltán Horváth, Gábor Balogh
  • Publication number: 20090312299
    Abstract: The invention is directed to a process of preparing substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3E- and -3Z-oxime isomers, as well as a process for the synthesis of the mixture of isomers and the pure isomers. The invention also relates to substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene20-yn-3-one-3E-oxime and substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3Z-oxime isomer. Further aspects of the invention include a composition comprising substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene20-yn-3-one-3E-oxime or substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3Z-oxime isomer, and methods of treatment using said compositions.
    Type: Application
    Filed: July 9, 2009
    Publication date: December 17, 2009
    Inventors: Zoltán TUBA, Sándor MAHÓ, György KESERÜ, József KOZMA, János HORVÁTH, Gábor BALOGH
  • Patent number: 7576226
    Abstract: The invention is directed to a process of preparing substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3E- and -3Z-oxime isomers, as well as a process for the synthesis of the mixture of isomers and the pure isomers. The invention also relates to substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene20-yn-3-one-3E-oxime and substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3Z-oxime isomer. Further aspects of the invention include a composition comprising substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene20-yn-3-one-3E-oxime or substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3Z-oxime isomer, and methods of treatment using said compositions.
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: August 18, 2009
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Zoltán Tuba, Sándor Mahó, György Keserü, József Kozma, János Horváth, Gábor Balogh
  • Publication number: 20080287404
    Abstract: The invention relates to a new process for the synthesis of high purity 17?-cyanomethyl-17?-hydroxy-estra-4,9-diene-3-one (further on dienogest) of formula (I) from 3-methoxy-17-hydroxy-estra-2,5(10)-diene of formula (V). The invention relates also to the high purity 17?-cyanomethyl-17?-hydroxy-estra-4,9-diene-3-one and pharmaceutical compositions containing that as active ingredient. The pharmaceutical compositions according to this invention contain high purity dienogest of formula (I) in which the total amount of impurities is less than 0.1%, while the amount of 4-bromo-dienogest is under the detection limit (0.02%) as active ingredient or at least one of the active ingredients and auxiliary materials, which are commonly used in practice, such as carriers, excipients or diluents.
    Type: Application
    Filed: October 11, 2006
    Publication date: November 20, 2008
    Inventors: Lajosne Dancsi, Sandor Maho, Antal Aranyi, Janos Horvath
  • Publication number: 20080200668
    Abstract: The invention relates to an industrial process for the preparation of 17-hydroxy-6?,7?;15?,16?-bismethylene-3-oxo-17?-pregn-4-ene-21-carboxylic acid ?-lactone of formula (I), and to the key-intermediates for this process.
    Type: Application
    Filed: October 11, 2005
    Publication date: August 21, 2008
    Inventors: Bela Soros, Judit Horvath, Gyorgy Galik, Jozsef Bodi, Zoltan Tuba, Sandor Maho, Gabor Balogh, Antal Aranyi
  • Publication number: 20080194812
    Abstract: The invention relates to a process for the preparation of 17-hydroxy-6?,7?;15?,16?-bismethylene-17?-pregn-4-ene-3-one-21-carboxylic acid ?-lactone of formula (I) as well as to key-intermediates for this process.
    Type: Application
    Filed: October 11, 2005
    Publication date: August 14, 2008
    Inventors: Gyorgy Galik, Judit Horvath, Bela Soros, Sandor Maho, Zoltan Tuba, Gabor Balogh